Results 61 to 70 of about 729,458 (285)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Australian climate warming: observed change from 1850 and global temperature targets [PDF]
Journal of Southern Hemisphere Earth Systems Science, 2023 Mean annual temperature is often used as a benchmark for monitoring climate change and as an indicator of its potential impacts. The Paris Agreement of 2015 aims to keep the global average temperature well below 2°C above pre-industrial levels, with a ...
Edward Hawkins +7 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Semiotics of Global Warming: Combating Semiotic Corrruption [PDF]
, 2007 The central focus of this paper is the disjunction between the findings of climate science in revealing the threat of global warming and the failure to act appropriately to these warnings. The development of climate science can be illuminated through the
Gare, Arran
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, 2013 A thermodynamic device placed outdoors, or a local ecosystem, is subject to a variety of different temperatures given by short-tem (daily) and long-term (seasonal) variations.
Beck, Christian, Yalcin, G. Cigdem
core +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
GLOBAL WARMING: A Critical View
Revista Brasileira de Climatologia, 2008 In the last 150 years, the mean global temperature rose about 0,7°C. Thisincrease is being attributed to the enhancement of the greenhouse effect dueanthropic activities, such as fossil fuel and tropical forest burning, that emit CO2– a greenhouse gas ...
Luiz Carlos Baldicero Molion
doaj +1 more source
Reducing Global Warming: The Potential of Organic Agriculture [PDF]
, 2012 Climate change mitigation is urgent, and adaptation to climate change is crucial, particularly in agriculture, where food security is at stake. Agriculture, currently responsible for 20-30% of global greenhouse gas emissions (counting direct and indirect
Davis, Joan +7 more
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FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
The Big Burp: A Bad Day in the Paleocene [PDF]
This lesson focuses on global warming and a possible connection with the Paleocene extinction event. Students will explore how a global warming episode associated with the release of methane from methane hydrate deposits could have been responsible for ...
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