Results 61 to 70 of about 739,711 (300)
Weather, climate, and the economy: Explaining risk perceptions of global warming, 2001-10 [PDF]
, 2014 Two series of national survey datasets (2001-10), supplemented with monthly temperature and precipitation data and unemployment data, are used to examine how weather and climate, economic performance, and individuals\u27 sociodemographic backgrounds and ...
Garand, James C +3 more
core +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Australian climate warming: observed change from 1850 and global temperature targets [PDF]
Journal of Southern Hemisphere Earth Systems Science, 2023 Mean annual temperature is often used as a benchmark for monitoring climate change and as an indicator of its potential impacts. The Paris Agreement of 2015 aims to keep the global average temperature well below 2°C above pre-industrial levels, with a ...
Edward Hawkins +7 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
GLOBAL WARMING: A Critical View
Revista Brasileira de Climatologia, 2008 In the last 150 years, the mean global temperature rose about 0,7°C. Thisincrease is being attributed to the enhancement of the greenhouse effect dueanthropic activities, such as fossil fuel and tropical forest burning, that emit CO2– a greenhouse gas ...
Luiz Carlos Baldicero Molion
doaj +1 more source
Reducing Global Warming: The Potential of Organic Agriculture [PDF]
, 2009 For a successful outcome at COP 15 in Copenhagen in December, viable policy paths for effective climate change mitigation need to be provided. In addition, adaptation is unavoidable.
Davis, Joan S., Müller, Adrian
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The Big Burp: A Bad Day in the Paleocene [PDF]
This lesson focuses on global warming and a possible connection with the Paleocene extinction event. Students will explore how a global warming episode associated with the release of methane from methane hydrate deposits could have been responsible for ...
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