Results 1 to 10 of about 13,059 (104)

Correlation between Plasma Interleukin-3, the α/β Globin Ratio, and Globin mRNA Stability

Anemia, 2014
Background. Globin chain synthesis (GCS) analysis is used in the diagnosis of thalassemia. However, the wide reference range limits its use as a decisive diagnostic tool. It has been shown thatαandβ  globin mRNAincrease through stimulation of cells by interleukin-3 (IL-3). Therefore, this study investigates the relationship between plasma IL-3 and theβ/
S. Rouhi Dehnabeh, R. Mahdian, S. Ajdary, E. Mostafavi, S. Khatami   +4 more
doaj   +3 more sources

The Correlation of ?/? mRNA Ratio with Clinical and Hematological Parameters in Patients with ?-thalassemia Syndrome

The Iraqi Journal of Medical Sciences, 2022
Background: Thalassemias are a group of genetically transmitted blood diseases characterized by defects in the production of ?- or ?-chains of hemoglobin called ?-thalassemia and ?-thalassemia, respectively.
May H. Yousif, Hind S. Al-Mamoori
doaj   +6 more sources

THE CORRELATION OF β/α MRNA RATIO WITH CLINICAL AND HEMATOLOGICAL PARAMETERS IN PATIENTS WITH β-THALASSEMIA SYNDROME

The Iraqi Journal of Medical Sciences, 2022
Background: Thalassemias are a group of genetically transmitted blood diseases characterized by defects in the production of α- or β-chains of hemoglobin called α-thalassemia and β-thalassemia, respectively.
May H. Yousif, Hind S. Al-Mamoori
doaj   +1 more source

Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells. [PDF]

PLoS ONE, 2011
Gene therapy for sickle cell disease will require efficient delivery of a tightly regulated and stably expressed gene product to provide an effective therapy. In this study we utilized the non-viral Sleeping Beauty (SB) transposon system using the SB100X
Lucas M Sjeklocha, Chang-Won Park, Phillip Y-P Wong, Mark J Roney, John D Belcher, Dan S Kaufman, Gregory M Vercellotti, Robert P Hebbel, Clifford J Steer   +8 more
doaj   +1 more source

Bradykinin stimulation of nitric oxide production is not sufficient for gamma-globin induction [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2014
Introduction. Hydroxycarbamide, used in therapy of hemoglobinopathies, enhances nitric oxide (NO) production both in primary human umbilical vein endothelial cells (HUVECs) and human bone marrow endothelial cell line (TrHBMEC).
Čokić Vladan P., Subotički Tijana, Beleslin-Čokić Bojana, Diklić Miloš, Milenković Pavle, Jovčić Gordana   +5 more
doaj   +1 more source

The αβ- andα2α1-globin mRNA ratios in different forms of α-thalassemia

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1996
AbstractThe present study provides information about the αβandα2α1-mRNA ratios in reticulocytes of normal adults and with different α-globin gene deficiencies; it found its origin in analytical data of blood samples from a Laotian couple and their newborn baby.
Smetanina, Natalia S., Leonova, Julia Y., Levy, Norman, Huisman, Titus H.J.   +3 more
openaire   +1 more source

Decrease of alpha-chains in beta-thalassemia

Thalassemia Reports, 2013
In the pathophysiology of beta-thalassemia, globin chain imbalance plays a central role in predicting red blood cell (RBC) life span and disease severity. Strategies to improve globin chain imbalance are therefore a legitimate target in the management of
M. Papadaki, George Vassilopoulos
doaj   +1 more source

Abnormal hemoglobin anti-Lepore Hong Kong compound with β0-thalassemia ameliorate thalassemia severity when co-inherited with α-thalassemia

Scientific Reports
Abnormal hemoglobin anti-Lepore Hong Kong is a rare βδ fusion variants resulting from non-homologous crossover during meiosis. Anti-Lepore Hong Kong is known to consistently exhibit significantly increased level of HbA2.
Xiuqin Bao, Jicheng Wang, Danqing Qin, Cuize Yao, Jie Liang, Kailing Liang, Li Du   +6 more
doaj   +1 more source

PGC-1α agonism via oral administration of ZLN005 induces fetal hemoglobin and is antisickling in sickle mice. [PDF]

Blood Adv
Benmhammed H, Sun Y, AlAbdullatif S, Chen A, Khan S, Zadeh AM, Mazile N, Beacham GM, Mahdaviani K, Williams C, Alekseyev YO, Campbell JD, Hagedorn EJ, Heaphy C, Klings ES, Steinberg MH, Cui S.   +16 more
europepmc   +1 more source

The Molecular Pathology of Non-Malignant Haematological Disease. [PDF]

Br J Biomed Sci
Blann AD, Dunn RG.
europepmc   +1 more source