Results 21 to 30 of about 13,059 (104)

A Cryoprotectant‐Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals

Advanced Materials, Volume 38, Issue 33, 12 June 2026.
A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee, Seongchan Kim, Jooyeun Chong, Min‐gyeong Kim, Kayeong Lim, Nan‐Ee Lee, Jahyun Koo, Jiheong Kang, Hyojin Lee   +8 more
wiley   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source

Computational Design of an mRNA Vaccine Targeting LRP6 for Triple‐Negative Breast Cancer Therapy

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Triple‐negative breast cancer (TNBC) presents a poorer prognosis than other breast cancer subtypes, attributed to its aggressive nature and the lack of specific therapeutic interventions. TNBC has high recurrence rates and limited survival despite current therapies, emphasizing the critical need for improved treatment options.
Pooriya Teimoori, Mohammadreza Heidari
wiley   +1 more source

mRNA Lipid Nanoparticles for Cell Engineering in Vivo and in Vitro: Current Applications and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Schematic diagram of mRNA‐lipid nanoparticles (mRNA‐LNP) and its functional mechanisms, applications, and challenges in cell engineering. This figure details the structural composition of mRNA‐LNPs and the delivery strategy, highlighting three core challenges.
Lina Li, Menglan Wang, Xiuhan Ye, Zhiyan Liu, Yijing Duan, Xiaoming Chen, Yue Ouyang, Qibiao Wu, Mengjuan Sun, Tian Xie   +9 more
wiley   +1 more source

Histone Deacetylase 9 Gene Deletion Ameliorates Aging‐Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Cellular senescence and mitochondrial dysfunction disrupt adipose tissue homeostasis during aging, but mechanisms remain unclear. HDAC9 expression increases with age in mouse adipose tissue and Hdac9 knockout mice showed reduced fat mass, senescence markers, and enhanced mitochondrial gene expression, respiration, and thiosulfate sulfurtransferase (Tst)
Brandee Goo, Samah Ahmadieh, Praneet Veerapaneni, Hong Shi, David S. Kim, Mourad Ogbi, Ronnie Chouhaita, Nicole Cyriac, Stephen Cave, Lingling Liu, Yong Zhang, Quansheng Du, Ha Won Kim, Yun Lei, Xin‐Yun Lu, Neal L. Weintraub   +15 more
wiley   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

An Integrated Genotyping Strategy for α/β-Thalassemia: Based on the Analysis of the Coding Sequences and Expression Levels of HBA2, HBA1, and HBB in Peripheral Blood mRNA. [PDF]

J Clin Lab Anal
Chen H, Yao Q, Fu M.
europepmc   +1 more source