Results 71 to 80 of about 13,059 (104)

A transferable SARS-CoV-2 IRES module enables dual translation initiation for enhanced antigen expression in COVID-19 mRNA vaccines. [PDF]

Mol Ther Nucleic Acids
Seo HY, Jung H, Lee SY, Jung HG, Cho H, Son YM, Bak Y, Hwang SY, Kim JH, Park IH, Shin JS, Oh JW.   +11 more
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The histone deacetylase inhibitor CT-101 flips the switch to fetal hemoglobin expression in sickle cell disease mice. [PDF]

PLoS One
Takezaki M, Li B, Xu H, Patel N, Lucas R, Cerbone RE, Koti S, Hendrick CL, Junker LH, Pace BS.   +9 more
europepmc   +1 more source

Gene Therapy of Beta Hemoglobinopathies. [PDF]

Biomedicines
Testa U, Pelosi E, Castelli G.
europepmc   +1 more source

Clinical outcome of an SCNT-derived <i>MSTN</i> knockout buffalo: a case study. [PDF]

Front Genome Ed
Singh P, Patel K, Tripathi G, Verma S, Kashyap K, Verma R, Jangir BL, Singh MK, Selokar NL.   +8 more
europepmc   +1 more source

Total ginsenosides enhance γ-globin expression and fetal hemoglobin production in β-thalassemia models. [PDF]

Front Pharmacol
Cai D, Chan Y, He G, Kong Y, Cai A, Guo Y, Zhu B.   +6 more
europepmc   +1 more source

Drugs Repurposing of Molecules Modulating Human Delta Globin Gene Expression via a Model of Transgenic Foetal Liver Cells: Implications for Beta-Hemoglobinopathy Therapeutics. [PDF]

Biomolecules
Simbula M, Manchinu MF, Olla S, Congiu M, Vaccargiu S, Caria CA, Poddie D, Ristaldi MS.   +7 more
europepmc   +1 more source

Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease. [PDF]

Cell Rep Med
Fontana L, Martinucci P, Amistadi S, Felix T, Mombled M, Tachtsidi A, Corre G, Chalumeau A, Hardouin G, Martin J, Romano O, Amendola M, Antoniou P, Miccio A.   +13 more
europepmc   +1 more source

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α/β-Globin mRNA ratio determination by multiplex quantitative real-time reverse transcription-polymerase chain reaction as an indicator of globin gene function

Clinical Biochemistry, 2007
Imbalance in alpha/beta-globin chains is an important determinant of thalassemia disease severity. This study examined the relationship between alpha/beta-globin mRNA ratio and disease severity in various thalassemia genotypes.alpha- and beta-globin mRNA contents of red blood cells of 75 alpha- and 32 beta-thalassemia subjects (5 with beta(0 ...
Supan Fucharoen, Arunee Jetsrisuparb, Goonnapa Fucharoen   +2 more
exaly   +3 more sources

Ratios of α-to β-globin mRNA and regulation of globin synthesis in reticulocytes

Nature, 1977
THE genomes of several mammalian species contain at least two α globin loci and a single β globin locus so that the ratio of α- to β-globin genes is 2 : 1 or more1–3. Despite this difference in number of genes, reticulocytes from these species synthesise equal numbers of α- and β-globin chains indicating that compensatory regulation must occur ...
J A, Phillips, P G, Snyder, H H, Kazazian   +2 more
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Decreased ratio of α- to β-globin mRNA in reticulocyte membrane RNA

International Journal of Biochemistry, 1987
The amount of RNA obtained from rabbit reticulocyte membrane-bound ribosomes by direct phenol extraction of washed membranes was inversely related to the hematocrit of the animals. Translation of the RNA in the reticulocyte translation system showed that the Mr = 30,000 protein reported to be a marker of membrane polysomes was also made by an ...
V A, Mezl, N, Cutcliffe
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