Results 51 to 60 of about 7,450 (200)

Shiga toxin binding to glycolipids and glycans. [PDF]

PLoS ONE, 2012
Immunologically distinct forms of Shiga toxin (Stx1 and Stx2) display different potencies and disease outcomes, likely due to differences in host cell binding.
Karen M Gallegos, Deborah G Conrady, Sayali S Karve, Thusitha S Gunasekera, Andrew B Herr, Alison A Weiss   +5 more
doaj   +1 more source

A CRISPR Screen Identifies LAPTM4A and TM9SF Proteins as Glycolipid-Regulating Factors

iScience, 2019
Summary: Glycosphingolipids (GSLs) are produced by various GSL-synthesizing enzymes, but post-translational regulation of these enzymes is incompletely understood.
Toshiyuki Yamaji, Tsuyoshi Sekizuka, Yuriko Tachida, Chisato Sakuma, Kanta Morimoto, Makoto Kuroda, Kentaro Hanada   +6 more
doaj   +1 more source

Anti-Gb3 monoclonal antibody inhibits angiogenesis and tumor development.

PLoS ONE, 2012
Inhibiting the growth of tumor vasculature represents one of the relevant strategies against tumor progression. Between all the different pro-angiogenic molecular targets, plasma membrane glycosphingolipids have been under-investigated.
Ariane Desselle, Tanguy Chaumette, Marie-Hélène Gaugler, Denis Cochonneau, Julien Fleurence, Nolwenn Dubois, Philippe Hulin, Jacques Aubry, Stéphane Birklé, François Paris   +9 more
doaj   +1 more source

Female Fabry disease patients and X-chromosome inactivation [PDF]

, 2018
Fabry disease is an X-linked inherited lysosomal storage disorder caused by mutations in the gene encoding α- galactosidase A (GLA). Once it was thought to affect only hemizygous males.
Gabig-Cimińska, Magdalena, Jakóbkiewicz-Banecka, Joanna, Juchniewicz, Patrycja, Kloska, Anna, Moskot, Marta, Piotrowska, Ewa, Tylki-Szymańska, Anna, Węgrzyn, Grzegorz   +7 more
core   +1 more source

Distributions of Globotriaosylceramide Isoforms, and Globotriaosylsphingosine and Its Analogues in an α-Galactosidase A Knockout Mouse, a Model of Fabry Disease.

PLoS ONE, 2015
Fabry disease is caused by deficient activity of α-galactosidase A (GLA) and characterized by systemic accumulation of glycosphingolipids, substrates of the enzyme.
Hideaki Sueoka, Mikio Aoki, Takahiro Tsukimura, Tadayasu Togawa, Hitoshi Sakuraba   +4 more
doaj   +1 more source

Globotriaosylceramide as a potential biomarker for auxiliary detection of lower respiratory tract infections of <i>Pseudomonas aeruginosa</i>. [PDF]

Exp Ther Med
Lower respiratory tract infections (LRTIs) caused by Pseudomonas aeruginosa (PA) are a significant health concern, notably among vulnerable populations.
Xu T, Li J, Dong Y, Zhao Z, Yu L.
europepmc   +2 more sources

Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics. [PDF]

, 2019
Inborn errors of metabolism (IEMs) are a group of inherited diseases with variable incidences. IEMs are caused by disrupting enzyme activities in specific metabolic pathways by genetic mutations, either directly or indirectly by cofactor deficiencies ...
Fiehn, Oliver, Ismail, Israa T, Showalter, Megan R   +2 more
core   +2 more sources

Synchronous Disease Kinetics in a Murine Model for Enterohemorrhagic E. coli Infection Using Food-Borne Inoculation [PDF]

, 2016
Upon colonization of the intestinal epithelium, the attaching and effacing (AE) pathogen Enterohemorrhagic Escherichia coli (EHEC) effaces microvilli and forms pedestal-like structures beneath the adherent bacterium.
Elsa N. Bou Ghanem, John M. Leong, Laurice J. Flowers   +2 more
core   +2 more sources

Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3

Frontiers in Molecular Biosciences, 2021
Glycolipids are present on the surfaces of all living cells and thereby represent targets for many protein receptors, such as lectins. Understanding the interactions between lectins and glycolipids is essential for investigating the functions of lectins ...
Lina Siukstaite, Lina Siukstaite, Anne Imberty, Winfried Römer, Winfried Römer, Winfried Römer   +5 more
doaj   +1 more source

Generation of a gene-corrected human isogenic iPSC line from a patient with Fabry disease carrying the GLA variant c.1069C>T using CRISPR/Cas9-mediated homology directed repair

Stem Cell Research
Fabry disease (FD) is an X-linked genetic disorder caused by mutations in the GLA gene, leading to α-galactosidase A deficiency and intracellular globotriaosylceramide (Gb3) accumulation.
Franziska Karl-Schöller, Maximilian Breyer, Eva Klopocki, Nurcan Üçeyler   +3 more
doaj   +1 more source