Results 91 to 100 of about 36,167 (318)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

On the Origin of Neutron Stars in Globular Clusters [PDF]

Symposium - International Astronomical Union, 1987
The formation of neutron stars in globular clusters is discussed in light of a number of recent results and, in particular, studies of the origin and evolution of the high luminosity x-ray binaries found in globular clusters. We argue that the neutron stars most probably arise from the accretion-induced collapse of white dwarfs in compact binary ...
openaire   +2 more sources

On the efficiency of field star capture by star clusters

, 2007
An exciting recent finding regarding scaling relations among globular clusters is the so-called 'blue tilt': clusters of the blue sub-population follow a trend of redder colour with increasing luminosity.
Baranov, Baumgardt, Bedin, Bekki, Bekki, Côté, D'Antona, de Oliveira Filho, Dopita, Fellhauer, Frank, Gnedin, H. Baumgardt, Harris, Jordán, Jordán, Lamers, Mieske, Mints, Morgan, Parmentier, Parmentier, Peng, Piotto, Prantzos, Recchi, Romanowsky, S. Mieske, Smith, Spitler, Strader, Thoul   +31 more
core   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Globular Clusters and Field Halo Stars [PDF]

Symposium - International Astronomical Union, 1988
Recent work on the chemistry and kinematics of the field halo population stars is reviewed, including the metallicity distribution function, elemental abundance patterns, primordial abundances, and their relations with stellar kinematics. The important role played by these stars in determining the ages of the globular clusters is discussed.
openaire   +2 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

M82, Starbursts, Star Clusters, and the Formation of Globular Clusters [PDF]

The Astrophysical Journal, 2005
We observed the nearby starburst galaxy M82 in CO in the higher frequency (2--1) transition to achieve an angular resolution below 1 arc second or 17 pc at the target. We resolved the molecular gas into a large number of compact clouds, with masses ranging from about 2x10^3 to 2x10^6 solar masses.
K. Y. Lo, Eric Keto, Luis C. Ho
openaire   +2 more sources

The origin of intergalactic thermonuclear supernovae

, 2004
The population synthesis method is used to study the possibility of explaining the appreciable fraction (20^+12_15%) of the intergalactic (no-host) type Ia supernovae observed in galaxy clusters (Gal-Yam ete al.
A. B. Marchant, A. G. Kuranov, A. G. Riess, A. Gal-Yam, B. V. Kukarkin, D. C. Heggie, D. C. Heggie, D. Pooley, E. Capellaro, E. I. Sorokina, E. P. Rubinstein, F. Hoyle, G. Nelemans, I. Iben Jr., J. R. Hurley, J. Whelan, K. A. Postnov, K. Nomoto, L. Spitzer Jr., M. B. Davis, M. Bellazzinni, M. G. Lee, M. M. Shara, N. N. Chugai, N. Trentham, N. V. Dunina-Barkovskaya, R. F. Webbink, R. Napiwotzki, R. W. Michie, S. L. Shapiro, S. Mikkola, S. Perlmutter, S. S. Kim, S. S. Kim, V. M. Lipunov, W. E. Harris, W. Lee   +36 more
core   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

oMEGACat. IV. Constraining the Ages of Omega Centauri Subgiant Branch Stars with HST and MUSE

The Astrophysical Journal
We present age estimates for over 8100 subgiant branch (SGB) stars in Omega Centauri ( ω Cen) to study its star formation history. Our large data set, which combines multi-wavelength Hubble Space Telescope photometry with MUSE metallicities, provides an ...
C. Clontz, A. C. Seth, A. Dotter, M. Häberle, M. S. Nitschai, N. Neumayer, A. Feldmeier-Krause, M. Latour, Z. Wang, S. O. Souza, N. Kacharov, A. Bellini, M. Libralato, R. Pechetti, G. van de Ven, M. Alfaro-Cuello   +15 more
doaj   +1 more source