Results 101 to 110 of about 36,679 (341)
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Dark Matter Halos in Galaxies and Globular Cluster Populations
, 2014 We combine a new, comprehensive database for globular cluster populations in all types of galaxies with a new calibration of galaxy halo masses based entirely on weak lensing.
Harris, Gretchen L. +2 more
core +1 more source
Globular Clusters and Field Halo Stars [PDF]
Symposium - International Astronomical Union, 1988 Recent work on the chemistry and kinematics of the field halo population stars is reviewed, including the metallicity distribution function, elemental abundance patterns, primordial abundances, and their relations with stellar kinematics. The important role played by these stars in determining the ages of the globular clusters is discussed.
openaire +2 more sources
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
oMEGACat. IV. Constraining the Ages of Omega Centauri Subgiant Branch Stars with HST and MUSE
The Astrophysical JournalWe present age estimates for over 8100 subgiant branch (SGB) stars in Omega Centauri ( ω Cen) to study its star formation history. Our large data set, which combines multi-wavelength Hubble Space Telescope photometry with MUSE metallicities, provides an ...
C. Clontz +15 more
doaj +1 more source
First Starbursts at high redshift: Formation of globular clusters
, 2003 Numerical simulations of a Milky Way-size galaxy demonstrate that globular clusters with the properties similar to observed can form naturally at z > 3 in the concordance Lambda-CDM cosmology.
A. V. Kravtsov +4 more
core +1 more source
Accretion of Gas by Stars in Globular Clusters [PDF]
Symposium - International Astronomical Union, 1980 One of the two classes of models that have been proposed for the production of X-rays in globular clusters involves accretion of gas by a more or less massive (10 M⊙–1000 M⊙) black hole at cluster centre (Cowie, Ostriker and Stark 1978 - COS). The accretion rates are not large (~1017 g s−1), and we may enquire how such rates compare with those for ...
openaire +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Modeling Formation of Globular Clusters: Beacons of Galactic Star Formation
, 2010 Modern hydrodynamic simulations of galaxy formation are able to predict accurately the rates and locations of the assembly of giant molecular clouds in early galaxies.
Gnedin, Oleg Y.
core +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source