Results 101 to 110 of about 107,331 (315)

Pattern of collagen IV expression in glomerular and mesenchymal basement membrane during fetal and postnatal period of Balb/c Mice [PDF]

Journal of Cell and Molecular Research, 2009
Basement membrane of glomerular mesangium (BMG) is a thin membrane which helps to support the capillary loops in a renal glomerulus and type IV collagen is require for complete BM formation during glomerulogenesis. In this investigation specific antibody
Mohammad Reza Nikravesh, M Jalali, MH Karimfar, AA Moeen, Saeedi Nejat Sh, Sh Mohammadi, H Rafighdoust   +6 more
doaj   +1 more source

Immunofluorescent Examination of Biopsies from Long-Term Renal Allografts [PDF]

, 1970
Immunofluorescent examination of open renal biopsies revealed clear-cut glomerular localization of immunoglobulins not related clearly to the quality of donor-recipient histocompatibility in 19 of 34 renal allografts.
Busch, Edgington, F. J. Dixon, J. J. McPhaul, L. Brettschneider, Peterson, Porter, Porter, Starzl, T. E. Starzl   +9 more
core   +1 more source

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, EarlyView.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

Electron Microscopic and Immunohistochemical Findings of the Epidermal Basement Membrane in Two Families with Nail-patella Syndrome

Acta Dermato-Venereologica, 2019
Nail-patella syndrome is an autosomal dominant disorder characterized by nail dysplasia and skeletal anomaly. Some patients have been shown to have ultrastructural abnormalities of the glomerular basement membrane that result in nephrosis.
Satoru Shinkuma, Hideki Nakamura, Manami Maehara, Shota Takashima, Toshifumi Nomura, Yasuyuki Fujita, Satoshi Hasegawa, Kazuko C. Sato-Matsumura, Riichiro Abe, Hiroshi Shimizu   +9 more
doaj   +1 more source

Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]

, 2017
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the ...
Bahamonde, Javiera, Ezquer, Fernando, Ezquer, Marcelo, Giraud Billoud, Maximiliano German   +3 more
core  

The role of heparan sulfate in the glomerular basement membrane [PDF]

Kidney International, 2008
Recent studies, including those by van den Hoven and colleagues, have challenged the classic negative-charge theory of glomerular filtration. However, the possibility remains that heparan sulfate in the glomerular basement membrane plays a role in maintaining the glomerular filtration barrier.
Ashio Yoshimura, K. Kimata, Hiroyuki Morita   +2 more
openaire   +3 more sources

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin‐6 (IL‐6); IL‐6 triggers intracellular pathways through interaction with the IL‐6 receptor (IL‐6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL‐6 −597G/A ...
Pavla Izakovicova, Simona Slezakova, Tereza Deissova, Hana Poskerova, Petra Borilova Linhartova, Ladislav Dusek, Katerina Kankova, Lydie Izakovicova Holla   +7 more
wiley   +1 more source

Effects of a Novel COL4A3 Homozygous/Heterozygous Splicing Mutation on the Mild Phenotype in a Family With Autosomal Recessive Alport Syndrome and a Literature Review

Molecular Genetics & Genomic Medicine
Background Alport syndrome involves chronic progressive kidney failure and extrarenal organ damage caused by COL4A3, COL4A4, and COL4A5 mutations. Methods We initially discerned a COL4A3 splicing mutation via next‐generation sequencing.
Dan Chen, Li Zhang, Jing Rao, Yan Zhou, Lujun Dai, Songsong Huang, Chunxia Yang, Qiuhan Bian, Tao Zhang, Xiaoyan Yang   +9 more
doaj   +1 more source

Asymptomatic autoantibodies associate with future anti-glomerular basement membrane disease.

Journal of the American Society of Nephrology, 2011
The pathophysiology of anti-glomerular basement membrane (anti-GBM) disease before clinical presentation is unknown. The presence of anti-GBM, anti-proteinase 3 (PR3), and anti-myeloperoxidase (MPO) antibodies associate with the disease at the time of ...
S. Olson, Charles B. Arbogast, T. P. Baker, D. Owshalimpur, D. Oliver, K. Abbott, C. Yuan   +6 more
semanticscholar   +1 more source