Results 91 to 100 of about 1,283,118 (184)

Nephropathies with pattern of structural alterations of the glomerular basement membrane: Case study

Revista Médica del Hospital General de México, 2018
Background: The pattern of structural alterations of the glomerular basement membrane comprises two hereditary glomerular diseases: Alport syndrome (AS) and thin basement membrane nephropathy (TBMN); both are rare entities.
L.A. Pedroza, M.V. Soto-Abraham
doaj   +1 more source

Long Term Follow Up of Hereditary Thrombotic Thrombocytopenic Purpura on Plasma Therapy for 9 Years: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 7.6‐year‐old boy with hTTP had fever‐induced hemorrhagic rash, MAHA, cerebral infarction, and renal impairment. After plasma therapy, symptoms were partially relieved; 9‐year follow‐up showed regular plasma transfusion was needed, with CKD Stage 3.
Dai Xiaomei, Chen Ruyue, Wu Shuang, Tang Hanyun, Lin Qiang, Li Xiaozhong   +5 more
wiley   +1 more source

Temporal Clustering of Antiglomerular Basement Membrane Disease in COVID-19 Pandemic: A Case Series

International Journal of Nephrology and Renovascular Disease, 2021
Rakesh Sebastian, Jegan Arunachalam, Manorajan Rajendran Department of Nephrology, Government Rajaji Hospital, Madurai Medical College, Madurai, Tamil Nadu, IndiaCorrespondence: Jegan ArunachalamDepartment of Nephrology, Government Rajaji Hospital ...
Sebastian R, Arunachalam J, Rajendran M
doaj  

Fulminant Multisystem IgA Vasculitis With Diffuse Alveolar Hemorrhage, Severe Gastrointestinal Hemorrhage, Paralytic Ileus, and Renal Involvement in an Adolescent: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 17‐year‐old girl with IgA vasculitis developed diffuse alveolar hemorrhage, severe gastrointestinal hemorrhage with paralytic ileus, and clinical renal involvement. Early bronchoscopy demonstrated diffuse airway bleeding, supported the diagnosis, enabled microbiological sampling, and informed postponement of pharmacological ...
Xianzhang Shan, Yancui Zhu
wiley   +1 more source

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source

The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats

Acta Medica Bulgarica, 2019
Background/objectives: Recent data suggest a role for heparanase in several proteinuric conditions. An increased glomerular heparanase expression is associated with loss of heparan sulfate in the glomerular basement membrane (GBM). The aim of the present
Roshan-Milani S., Khalilpour J., Fard A. Abdollahzade   +2 more
doaj   +1 more source

Genetic Disorders of Glomerular Basement Membranes

, 2010
This review provides current information about glomerular disorders that arise directly from inherited abnormalities in extracellular matrix proteins intrinsic to the glomerular basement membrane (Alport syndrome, thin basement membrane nephropathy ...
Clifford E. Kashtan, Yoav Segal
core   +1 more source

Bronchiectasis as the Sentinel Manifestation of ANCA‐Associated Vasculitis: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 10, October 2026.
A 74‐year‐old woman was treated for 7 years as culture‐negative bronchiectasis before palpable purpura, haemoptysis, and acute kidney injury revealed MPO‐ANCA vasculitis with pauci‐immune crescentic glomerulonephritis. Rituximab‐based induction produced near‐complete resolution of the pulmonary consolidations and sustained clinical remission at 15 ...
Andrew Kim, Celine Vartany, Siddhanth Hegde, Kristie Lau, Lynette Tatosyan, Brannen Liang   +5 more
wiley   +1 more source

Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis

Linchuang shenzangbing zazhi
Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular ...
Yan-yu Zhang, Xin Lyu, Xiao-guang Huang, Xiao-jun Ren, Xue Wang, Wei-min Yu   +5 more
doaj   +1 more source

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

Nature Communications, 2019
The glomerular filtration barrier is a complex structure in charge of renal ultrafiltration. Here the authors present a glomerulus-on-a-chip for disease modelling and high-throughput drug screening where human podocytes and human glomerular endothelial ...
Astgik Petrosyan, Paolo Cravedi, Valentina Villani, Andrea Angeletti, Joaquin Manrique, Alessandra Renieri, Roger E. De Filippo, Laura Perin, Stefano Da Sacco   +8 more
doaj   +1 more source