Results 71 to 80 of about 1,283,118 (184)

Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Kidney disease is a major microvascular complication of diabetes, affecting approximately 40% of individuals with diabetes, and is a leading cause of end‐stage renal disease. Besides the functional consequences of hyperglycemia; hemodynamic alterations are well understood.
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan Chandrahasa Shetty, Sujina Simon Sailet   +3 more
wiley   +1 more source

Electron Microscopic and Immunohistochemical Findings of the Epidermal Basement Membrane in Two Families with Nail-patella Syndrome

Acta Dermato-Venereologica, 2019
Nail-patella syndrome is an autosomal dominant disorder characterized by nail dysplasia and skeletal anomaly. Some patients have been shown to have ultrastructural abnormalities of the glomerular basement membrane that result in nephrosis.
Satoru Shinkuma, Hideki Nakamura, Manami Maehara, Shota Takashima, Toshifumi Nomura, Yasuyuki Fujita, Satoshi Hasegawa, Kazuko C. Sato-Matsumura, Riichiro Abe, Hiroshi Shimizu   +9 more
doaj   +1 more source

A human glomerular SAGE transcriptome database [PDF]

, 2009
Background: To facilitate in the identification of gene products important in regulating renal glomerular structure and function, we have produced an annotated transcriptome database for normal human glomeruli using the SAGE approach.
Kulak, Stephen C., Kulak Stephen C, Anna Granqvist, Stephen C Kulak, Wolfgang Fierlbeck, Ballermann, Barbara J., Jenny Nyström, Granqvist, Anna, Granqvist Anna, Ballermann Barbara J, Fierlbeck, Wolfgang, Nyström, Jenny, Fierlbeck Wolfgang, Nyström Jenny, Barbara J Ballermann   +14 more
core   +2 more sources

The role of heparan sulfate in the glomerular basement membrane [PDF]

, 2008
Recent studies, including those by van den Hoven and colleagues, have challenged the classic negative-charge theory of glomerular filtration. However, the possibility remains that heparan sulfate in the glomerular basement membrane plays a role in ...
Yoshimura, A., Morita, H., Kimata, K.
core   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Binding Truths: Seronegative Anti-Glomerular Basement Membrane Disease Mediated by IgM Anti-Glomerular Basement Membrane Antibodies

Kidney International Reports, 2023
Marilina Antonelou, Harry Horsley, Lauren Heptinstall, Mark Harber, Alan D. Salama   +4 more
doaj   +1 more source

Effects of a Novel COL4A3 Homozygous/Heterozygous Splicing Mutation on the Mild Phenotype in a Family With Autosomal Recessive Alport Syndrome and a Literature Review

Molecular Genetics & Genomic Medicine
Background Alport syndrome involves chronic progressive kidney failure and extrarenal organ damage caused by COL4A3, COL4A4, and COL4A5 mutations. Methods We initially discerned a COL4A3 splicing mutation via next‐generation sequencing.
Dan Chen, Li Zhang, Jing Rao, Yan Zhou, Lujun Dai, Songsong Huang, Chunxia Yang, Qiuhan Bian, Tao Zhang, Xiaoyan Yang   +9 more
doaj   +1 more source

Recurrent anti-GBM disease with pulmonary artery aneurysms

JRSM Open, 2016
We present the first known case of pulmonary artery aneurysms as a feature of Recurrent Anti-Glomerular Basement Membrane disease.
John Dixon, Hannah Wilkinson, Kamran Iqbal, Virginia Quan   +3 more
doaj   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Nanoscale protein architecture of the kidney glomerular basement membrane

eLife, 2013
In multicellular organisms, proteins of the extracellular matrix (ECM) play structural and functional roles in essentially all organs, so understanding ECM protein organization in health and disease remains an important goal.
Hani Suleiman, Lei Zhang, Robyn Roth, John E Heuser, Jeffrey H Miner, Andrey S Shaw, Adish Dani   +6 more
doaj   +1 more source