Results 61 to 70 of about 1,283,118 (184)
Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]
, 2013 Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
David Sánchez-Martín (264504) +40 more
core +1 more source
Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]
, 1990 The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Kröger, Stephan +5 more
core +1 more source
Phytotherapy Research, EarlyView.AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue +11 more
wiley +1 more source
The Glomerular Filtration Barrier: Components and Crosstalk
International Journal of Nephrology, 2012 The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules.
Madhav C. Menon +2 more
doaj +1 more source
Small Methods, EarlyView.Nature‐inspired bi‐functionalized magnetic nanoparticles are engineered for the rapid, non‐invasive extraction of cell‐free DNA from unprocessed urine for liquid biopsy. These cationic particles leverage electrostatic interactions to outperform conventional kits, enhancing the recovery of short DNA fragments while maintaining DNA integrity.
Dina Haddad +4 more
wiley +1 more source
Thin-Glomerular-Basement-Membrane Nephropathy [PDF]
, 2002 Thin-glomerular-basement-membrane (TGBM) nephropathy is among the most common causes of isolated hematuria. This autosomal dominant disorder is characterized by diffuse thinning of the GBM and is diagnosed by electron microscopic examination of renal ...
KAMYAR KALANTAR-ZADEH +5 more
core +1 more source
VIEW, EarlyView.Reduction of high‐molecular‐weight von Willebrand factor disrupts the platelet–complement amplification loop, attenuating microvascular thrombosis, complement deposition, endothelial injury, and organ damage in complement‐mediated thrombotic microangiopathy.
Yang Li +17 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis
Journal of Diabetes Investigation, EarlyView.ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li +5 more
wiley +1 more source
Thin glomerular basement membrane nephropathy and other collagenopathies
, 2018 The discovery of a thin glomerular basement membrane in a renal biopsy without any other abnormalities can be explained in a number of ways. This could be an early biopsy in a patient with Alport syndrome, or it could be an individual who is a carrier ...
Marie Claire Gubler +2 more
core +1 more source