Results 81 to 90 of about 52,583 (282)
Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]
, 2017 IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna +11 more
core +2 more sources
Multimodal Assessment of Kidney Quality During 24‐h of Normothermic Machine Perfusion
Artificial Organs, EarlyView.Normothermic machine perfusion (NMP) has emerged as a promising tool for assessing kidney quality prior to transplantation; however, reliable biomarkers remain to be established. In this study, thirteen porcine kidneys were perfused for 24 h using an autologous leukocyte‐filtered whole blood‐based perfusate applying urine recirculation.
Marlene Pühringer +22 more
wiley +1 more source
NEPHROPATHIES WITH THIN GLOMERULAR BASEMENT MEMBRANE
Turkish Journal of Nephrology, 2019 -
Duygu ÖLMEZ, Salih KAVUKÇU
doaj
Nonenzymatic Glycosylation of Glomerular Basement Membrane
Kidney and Blood Pressure Research, 1981 To test the hypothesis that increased nonenzymatic glycosylation contributes to the microangiopathic sequelae of diabetes, we examined the interaction of glucose with basement membranes in vivo and in vitro. The level of nonenzymatic glycosylation, determined by hydroxymethylfurfuraldehyde (HMF) generation, in glomerular basement membrane (GMB ...
M P, Cohen, E, Urdanivia, V Y, Wu
openaire +2 more sources
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
, 2005 A 30 year old man is referred for a medical check up before taking a life insurance policy. He is asymptomatic, gives no relevant history, is on no treatment and physical examination is unremarkable. Routine dip-stick analysis of a midstream specimen of
Vella, Mario P.
core
The Glomerular Basement Membrane [PDF]
, 1981 The basement membrane of the glomerular capillaries of the mammalian kidney has been a favorite object for studies on the structure, function, and composition of basement membranes because of its important biological role in glomerular filtration of macromolecules, and because of the relative ease with which it can be isolated for study, free from ...
openaire +2 more sources
The Glomerular Filtration Barrier: Components and Crosstalk
International Journal of Nephrology, 2012 The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules.
Madhav C. Menon +2 more
doaj +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
REGULATORY ROLE OF OX22HIGH T-CELLS IN MERCURY-INDUCED AUTOIMMUNITY IN THE BROWN NORWAY RAT [PDF]
, 1993 The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon γ and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly ...
Mathieson, PW, Oliveira, DB, Thiru, S
core +1 more source