Results 101 to 110 of about 1,283,118 (184)

uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor

Aging Cell, Volume 25, Issue 10, October 2026.
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng, Xiaozhu Zeng, Jing Guo, Lihong Li, Shirui Zou, Nan Liu, Shuai He, Lanzhen Yan, Qiong Wang, Yongjie Zhu, Ben Wang, Dong Yang, Longbao Lv, Xudong Zhao   +13 more
wiley   +1 more source

On the measurement of glomerular filtration rate: An odyssey into the milieu intérieur

Experimental Physiology, EarlyView.
Anders Møller Greve, Anna Agnes Lytzen, Hrefna Sæunn Einarsdóttir, Michael Perch, Ronan M. G. Berg   +4 more
wiley   +1 more source

Five‐Year Outcomes and Clinicopathological Correlations of Kidney Transplants From Deceased Donors With Diabetes

Clinical Transplantation, Volume 40, Issue 10, October 2026.
ABSTRACT Background Kidneys from deceased donors with diabetes mellitus are refused because diabetes is considered a marker of lower organ quality. We evaluated 5‐year outcomes according to donor‐recipient diabetes status and, secondarily, the prognostic value of pre‐implantation histopathological findings among accepted diabetic donor kidneys ...
Marina Colella‐Santos, Pedro Henrique Pepato, Henrique Machado de Sousa Proença, Luiz Antonio Ribeiro de Moura, José Medina‐Pestana, Renato Demarchi Foresto, Lúcio Requião‐Moura   +6 more
wiley   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1816-1834, October 2026.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1744-1758, October 2026.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

Alterations of glomerular basement membrane charge and structure in diabetic nephropathy.

, 1995
We examined glomerular basement membrane anionic site distribution identified by cationic gold in seven patients with insulin-dependent and four patients with non-insulin-dependent diabetes mellitus, presenting a spectrum of clinical and glomerular ...
Davison, AM, Crellin, DM, Goode, NP, Shires, M, Aparicio, SR   +4 more
core   +1 more source

Selective glomerular hypofiltration is associated with glucometabolic disturbances in the general population

Journal of Internal Medicine, Volume 300, Issue 4, Page 499-512, October 2026.
Abstract Background Discordance between cystatin C‐ and creatinine‐based estimated glomerular filtration rate (eGFR) has been linked to adverse outcomes. A low eGFRcys/eGFRcr‐ratio, conceptualized as selective glomerular hypofiltration syndrome (SGHS), has been hypothesized to reflect early metabolic kidney vulnerability, although non‐glomerular ...
Christopher Nilsson, Agne Laucyte‐Cibulskiene, Amra Jujic, Marcus A. Ohlsson, Gregor Guron, Maria K. Svensson, Maria Weiner, P. Andreas Jonsson, Johan Ärnlöv, Gunnar Engström, Anders Grubb, Anders Larsson, Martin Magnusson, Anders Christensson   +13 more
wiley   +1 more source

Clinical, genetic and molecular aspects of membranous nephropathy [PDF]

, 2011
Membranous Nephropathy (MN) is one of the leading causes of end-stage renal disease (ESRD). MN is an autoimmune disease in which autoantibodies target antigens at the level of the glomerular basement membrane.
Stanescu, H.C.
core  

Distinct Complement Activation Profiles Between NELL1‐ and PLA2R‐Associated Membranous Nephropathy: A Clinicopathological and Proteomic Study

Nephrology, Volume 31, Issue 10, October 2026.
We compared the clinicopathological features and complement activation profiles of PLA2R‐associated and NELL1‐associated membranous nephropathy. NELL1‐associated membranous nephropathy was associated with older age, more chronic histologic changes and less glomerular C3 and C4d deposition.
Taihei Suzuki, Kang Dedong, Kunio Kawanishi, Masataka Ueda, Yuki Kajio, Kazuki Kobayashi, Nobuhiro Kanazawa, Mayumi Takahashi‐Kobayashi, Joichi Usui, Masaki Baba, Hirokazu Honda, Kazuho Honda, Masayuki Iyoda   +12 more
wiley   +1 more source

Increase in podocyte number induced by SV40T antigen during the fetal stage does not expand glomerular size in mice

Physiological Reports, Volume 14, Issue 19, October 2026.
Introduction of SV40 large T antigen (SV40T) in embryonic mouse podocytes via a Tet‐On system markedly increased podocyte number at birth (P0). However, the supernumerary podocytes formed multilayers and detached into the urinary space, failing to enlarge the glomerular tuft area.
Taiji Matsusaka, Koichiro Ichimura, Takayuki Miyaki, Masahiro Koizumi   +3 more
wiley   +1 more source