Results 131 to 140 of about 107,331 (315)

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

Nature Communications, 2019
The glomerular filtration barrier is a complex structure in charge of renal ultrafiltration. Here the authors present a glomerulus-on-a-chip for disease modelling and high-throughput drug screening where human podocytes and human glomerular endothelial ...
Astgik Petrosyan, Paolo Cravedi, Valentina Villani, Andrea Angeletti, Joaquin Manrique, Alessandra Renieri, Roger E. De Filippo, Laura Perin, Stefano Da Sacco   +8 more
doaj   +1 more source

Molecular and Cellular Events Mediating Glomerular Podocyte Dysfunction and Depletion in Diabetes Mellitus

Frontiers in Endocrinology, 2014
The essential function of the kidney is to ensure formation of relatively protein-free ultra-filtrate, urine. The rate of filtration and composition of the primary renal filtrate is determined by the transport of fluid and solutes across the glomerular ...
Ram K Menon, Moin A Saleem, Gavin Iain Welsh, P eAnil Kumar   +3 more
doaj   +1 more source

Prevalence of Proteinuria in Dogs With Immune‐Mediated Disease

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Proteinuria is associated with autoimmune diseases in humans. There is minimal evidence in the veterinary literature on proteinuria and its association with immune‐mediated disease in dogs. Hypothesis Renal proteinuria is common in dogs with immune‐mediated disease. Dogs presenting with pyrexia or immune‐mediated polyarthritis (IMPA)
James C. Barton, Alexander J. German, Erin M. O'Connell   +2 more
wiley   +1 more source

Vaccination of Cattle with the N Terminus of LppQ of Mycoplasma mycoides subsp. mycoides Results in Type III Immune Complex Disease upon Experimental Infection [PDF]

, 2015
Contagious bovine pleuropneumonia (CBPP) is a serious respiratory disease of cattle caused by Mycoplasma mycoides subsp. mycoides. Current vaccines against CBPP induce short-lived immunity and can cause severe postvaccine reactions. Previous studies have
Brown RD, Bygrave A, Churg J, Litamoi J, Provost A, Rawadi G, Thomson GR, Villegas P   +7 more
core   +2 more sources

Statin attenuates experimental anti-glomerular basement membrane glomerulonephritis together with the augmentation of alternatively activated macrophages.

American Journal of Pathology, 2010
Macrophages are heterogeneous and include classically activated M1 and alternatively activated M2 macrophages, characterized by pro- and anti-inflammatory functions, respectively.
E. Fujita, A. Shimizu, Y. Masuda, N. Kuwahara, T. Arai, S. Nagasaka, Kaoru Aki, A. Mii, Y. Natori, Y. Iino, Y. Katayama, Y. Fukuda   +11 more
semanticscholar   +1 more source

Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis

Linchuang shenzangbing zazhi
Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular ...
Yan-yu Zhang, Xin Lyu, Xiao-guang Huang, Xiao-jun Ren, Xue Wang, Wei-min Yu   +5 more
doaj   +1 more source

The Presence of Anti-Glomerular Basement Membrane Antibodies in Peripheral Blood [PDF]

, 1969
John J. McPhaul, Frank J. Dixon
openalex   +1 more source

Glomerular basement membrane necrosis and crescent organization

Kidney International, 1988
In order to reveal structural damage to the glomerular basement membranes occurring in crescentic glomerulonephritis and the subsequent connective tissue organization of the crescent, 14 kidney biopsies were treated with detergents to remove cellular components and the tissue remaining examined by transmission (TEM) and scanning (SEM) electron ...
Stephen M. Bonsib, Stephen M. Bonsib
openaire   +3 more sources

What triggered massive hemoptysis in Goodpasture syndrome with isolated pulmonary involvement in a 14-year-old boy?

The Turkish Journal of Pediatrics, 2019
Goodpasture syndrome is a rare, autoimmune disease associated with the development of antibodies against a specific antigen both in glomerular basement membrane and alveolar basement membrane. It is very rare in childhood and its incidence is not known.
Tuğba Şişmanlar-Eyüboğlu, Ayşe Tana Aslan, Deniz Gezgin-Yıldırım, Necla Buyan, Serhat Emeksiz, Gökhan Kalkan   +5 more
doaj   +1 more source

Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy [PDF]

, 2018
Epidermolysis bullosa (EB) is caused by mutations in as many as 19 distinct genes. We have developed a next-generation sequencing (NGS) panel targeting genes known to be mutated in skin fragility disorders, including tetraspanin CD151 expressed in ...
Abiri, Maryam, Aristodemou, Sophia, Ertel, Adam, Fortina, Paolo, Kajbafzadeh, Abdol-Mohammad, Kariminejad, Ariana, Liu, Lu, Londin, Eric, Mahmoudi, Hamidreza, McGrath, John A., Saeidian, Amir Hossein, Touati, Andrew, Uitto, Jouni, Vahidnezhad, Hassan, Youssefian, Leila, Zeinali, Sirous   +15 more
core   +1 more source