Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA
Advanced Science, EarlyView.This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li +14 more
wiley +1 more source
Advanced Science, EarlyView.Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen +7 more
wiley +1 more source
The relationship between glomerular filtration rate and sodium reabsorption by the proximal tubule of the rat nephron [PDF]
, 1968 Barry M. Brenner +2 more
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Advanced Science, EarlyView.This review explores the transformative potential of lipid‐based nanoparticles (LNPs) in renal cell carcinoma (RCC) therapy. It systematically analyzes six LNP platforms‐from liposomes to hybrid nanoparticles‐highlighting their unique advantages in targeted drug delivery, resistance reversal, and immunomodulation.
Wei Yao +7 more
wiley +1 more source
Renal Blood Flow, Glomerular Filtration Rate, Renal PAH Extraction Ratio, and the Role of the Renal Vasomotor Nerves in the Unanesthetized Rabbit [PDF]
, 1963 PAUL I. Pascoe, Yvonne Körner
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Regulating Enzyme Activity via Microaggregates Mediated by Phase Separation
Advanced Science, EarlyView.An enzyme‐sequestration strategy for combating postoperative pancreatic fistula (POPF) is developed, employing a D‐peptide called DPMD to induce liquid–solid phase separation (LSPS) of pancreatic proteases. This LSPS‐driven microaggregate approach effectively isolates trypsin and chymotrypsin from their substrates, thereby reducing pancreatic fluid ...
Yang Wang +7 more
wiley +1 more source
Prognostic Value of Glomerular Filtration Rate in Diabetic Patients with Acute Myocardial Infarction
Medisur, 2015 Background: low glomerular filtration rate is a known poor prognostic factor in acute coronary syndrome, particularly when associated with diabetes mellitus.Objective: to determine the prognostic value of glomerular filtration rate in hospitalized ...
Ailed Elena Rodríguez Jiménez
doaj +2 more sources
Some determinants of the effects of VAL-5-angiotensin II amide on glomerular filtration rate and sodium excretion in dogs [PDF]
, 1969 John C. McGiff +4 more
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Long‐Term Nutritional Benefits of Laparoscopic Pancreatoduodenectomy Over Open Surgery
Annals of Gastroenterological Surgery, EarlyView.Minimally invasive laparoscopic pancreaticoduodenectomy (LPD) significantly improves long‐term nutritional outcomes compared to open pancreaticoduodenectomy (OPD). LPD patients demonstrated better preservation of muscle mass index (PMI) and a lower incidence of postoperative fatty liver.
Koki Kurahashi +9 more
wiley +1 more source
Editorial: Glomerular filtration rate in Chronic Kidney Disease
Frontiers in Medicine, 2023 Ana Maria Cusumano +2 more
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