Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]
, 2017 Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska +8 more
core +3 more sources
Diabetes, obesity and metabolism, 2019 Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes.
M. Kanbay +10 more
semanticscholar +1 more source
Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria [PDF]
, 2018 Background: The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with microalbuminuria (MA) is unknown.
Currie, Gemma E. +11 more
core +5 more sources
Estimated glomerular filtration rate correlates poorly with four-hour creatinine clearance in critically ill patients with acute kidney injury. [PDF]
, 2013 Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is
Kirwan, CJ, Macphee, IA, Philips, BJ
core +2 more sources
Journal of the American Medical Association (JAMA), 2014 IMPORTANCE The established chronic kidney disease (CKD) progression end point of end-stage renal disease (ESRD) or a doubling of serum creatinine concentration (corresponding to a change in estimated glomerular filtration rate [GFR] of −57% or greater ...
J. Coresh +26 more
semanticscholar +1 more source
PENGARUH SUPLEMENTASI KAPSUL EKSTRAK IKAN GABUS TERHADAP LAJU FILTRASI GLOMERULUS PADA SINDROM NEFROTIK RESISTEN STEROID ANAK [PDF]
, 2015 Background Steroid Resistant Nephrotic Syndrome (SRNS) is one of nephrotic syndrome classification which do not respond to therapy with steroid. Children with SRNS have high risk of decline of kidney’s function.
Ashila, Nisa, Muryawan, Heru
core
Measurement and Estimation of Glomerular Filtration Rate in Children.
Advances in Chronic Kidney Disease, 2017 Rapid, accurate, and precise measures of kidney function are essential for daily management of patients. While plasma and urinary clearances provide the greatest accuracy for assessing glomerular filtration rate (GFR), these are often impractical ...
Ayesa N. Mian, G. Schwartz
semanticscholar +1 more source
Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification
FEBS Open Bio, EarlyView.Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski +13 more
wiley +1 more source
Tubular secretion of creatinine and kidney function: an observational study. [PDF]
, 2020 BackgroundPrior papers have been inconsistent regarding how much creatinine clearance (CrCl) overestimates glomerular filtration rate (GFR). A recent cross-sectional study suggested that measurement error alone could entirely account for the longstanding
Hsu, Chi-Yuan +5 more
core
Renal Hyperfiltration and the Development of Microalbuminuria in Type 1 Diabetes [PDF]
, 2009 OBJECTIVE: The purpose of this study was to examine prospectively whether renal hyperfiltration is associated with the development of microalbuminuria in patients with type 1 diabetes, after taking into account known risk factors.
Aschengrau, Ann +6 more
core +3 more sources