Results 51 to 60 of about 192,887 (307)

Automating and estimating glomerular filtration rate for dosing medications and staging chronic kidney disease

International Journal of General Medicine, 2014
Katy E Trinkley,1 S Michelle Nikels,2 Robert L Page II,1 Melanie S Joy11Skaggs School of Pharmacy and Pharmaceutical Sciences, 2School of Medicine, University of Colorado, Aurora, CO, USA Objective: The purpose of this paper is to serve as a review for ...
Trinkley KE, Nikels SM, Page RL II, Joy MS   +3 more
doaj  

Serum cystatin C is a sensitive early marker for changes in the glomerular filtration rate in patients undergoing laparoscopic surgery

Clinics, 2014
OBJECTIVE:Pneumoperitoneum during laparoscopy results in transient oliguria and decreased glomerular filtration and renal blood flow. The presence of oliguria and elevated serum creatinine is suggestive of acute renal injury.
Rodrigo Moreira e Lima, Lais Helena Camacho Navarro, Giane Nakamura, Daneshvari R. Solanki, Yara Marcondes Machado Castiglia, Pedro Tadeu Galvão Vianna, Eliana Marisa Ganem   +6 more
doaj   +1 more source

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

Biomedical Applications of Nanozymes: An Enzymology Perspective

Angewandte Chemie, EarlyView.
With a lens of enzymology, this review compares nanozymes with enzymes using the Michaelis‐Menten model and differences in KM and kcat along with catalysis in complex biological environment. The implications of these differences in biomedical applications of nanozymes are then described with a statistical analysis of the trend of therapeutic use of ...
Vasily G. Panferov, Xiaohan Zhang, Ka‐Ying Wong, Jung Heon Lee, Juewen Liu   +4 more
wiley   +2 more sources

Estimating glomerular filtration rate in a population-based study

Vascular Health and Risk Management, 2010
Anoop Shankar1, Kristine E Lee2, Barbara EK Klein2, Paul Muntner3, Peter C Brazy4, Karen J Cruickshanks2,5, F Javier Nieto5, Lorraine G Danforth2, Carla R Schubert2,5, Michael Y Tsai6, Ronald Klein21Department of Community Medicine, West Virginia ...
Anoop Shankar, Kristine E Lee, Barbara EK Klein, et al   +3 more
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Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone

Physiological Reports, 2019
We have previously demonstrated that dexamethasone administered to pregnant rats during specific times during gestation results in a reduction in glomerular number and hypertension in offspring at 2 and 6 months of age.
Jyoti Jain, Susan K. Legan, Issa Alhamoud, Jyothsna Gattineni, Michel Baum   +4 more
doaj   +1 more source

Renal Function Assessment Gap in Clinical Practice: An Awkward Truth

Kidney & Blood Pressure Research, 2020
Introduction: An accurate assessment of renal function is needed in the majority of clinical settings. Unfortunately, the most used estimated glomerular filtration rate (eGFR) formulas are affected by significant errors in comparison to gold standards ...
Francesco Trevisani, Federico Di Marco, Umberto Capitanio, Alessandro Larcher, Arianna Bettiga, Flaviano Dosio, Michele Ghidini, Gianluca Del Conte, Riccardo Vago, Alessandra Cinque, Luigi Gianolli, Andrea Salonia, Alberto Briganti, Sergio Luis-Lima, Natalia Negrín-Mena, Francesco Montorsi, Esteban Porrini   +16 more
doaj   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science, EarlyView.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

DIABETIC KIDNEY DISEASE: DEFINITION, DIAGNOSIS, DIFFERENT PROGRESSIVE STAGES, CLASSIFICATION

Revista de la Sociedad Argentina de Diabetes, 2018
Chronic kidney disease (CKD) is classified according to the cause, the stage of glomerular filtration and albuminuria. Diabetic kidney disease (DKD) according to the classification of glomerular filtration (GF) and the quantification of albuminuria.
María Estela Canda
doaj   +1 more source