GLP-1 RAs for Treating Metabolic Dysfunction-Associated Steatosis Liver Disease: From GLP-1 Discovery to FDA Approval: A Comprehensive Narrative Review [PDF]
PharmaceuticalsBackground: Metabolic dysfunction-associated steatosis liver disease (MASLD), formerly termed nonalcoholic fatty liver disease (NAFLD), has emerged as the most prevalent cause of chronic liver disease worldwide.
Olfa Khalifa, Abdelilah Arredouani
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An Update on GLP‐1 Receptor Agonists [PDF]
Journal of DiabetesZachary Bloomgarden
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Age and Gender Effects on Genotoxicity in Diesel Exhaust Particles Exposed C57BL/6 Mice
Biomolecules, 2021 There is growing evidence that the accumulation of DNA damage induced by fine particulate matter (PM2.5) exposure is an underlying mechanism of pulmonary disease onset and progression.
Joong Won Lee +8 more
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Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. [PDF]
PLoS ONE, 2010 GLP-1 has a variety of anti-diabetic effects. However, native GLP-1 is not suitable for therapy of diabetes due to its short half-life (t1/2168 h. Intraperitoneal glucose tolerance test (IPGTT) in mice showed that GLP-1/hIgG2 significantly decreased ...
Qinghua Wang +6 more
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Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. [PDF]
PLoS ONE, 2013 Glucagon-like-peptide-1 (GLP-1) is a gut- and neuro-peptide with an important role in the regulation of food intake and glucose metabolism. Interestingly, GLP-1 receptors (GLP-1R) are expressed in key mesolimbic reward areas (including the ventral ...
Rozita H Shirazi +2 more
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Pharmaceuticals, 2022 Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes.
Lei Sun +8 more
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Frontiers in Physiology, 2020 Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects.
Zhuo Fu +8 more
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Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor. [PDF]
PLoS ONE, 2012 Glucagon-like peptide-1 (GLP-1) released from intestinal L cells in response to nutrients has many physiological effects but particularly enhances glucose-dependent insulin release through the GLP-1 receptor (GLP-1R).
Naichang Li, Jing Lu, Gary B Willars
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Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats. [PDF]
PLoS ONE, 2015 In recent years, Abscisic Acid (ABA) has been demonstrated to be involved in the regulation of glucose homeostasis in mammals as an endogenous hormone, by stimulating both insulin release and peripheral glucose uptake.
Santina Bruzzone +9 more
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