Results 241 to 250 of about 114,692 (269)

Influence of glucagon on pancreatic exocrine secretion.

, 1969
Walter P. Dyck, J Rudick, Barton Hoexter, Henry D. Janowitz   +3 more
openalex  

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Electric charge and salting in/out effects on glucagon's dipole moments and polarizabilities using the GruPol database. [PDF]

Acta Crystallogr B Struct Sci Cryst Eng Mater
Ligorio RF, Gehle RHM, Dos Santos LHR, Krawczuk A.   +3 more
europepmc   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Identification of a vimentin-expressing α-cell phenotype in CF and normal pancreas. [PDF]

J Endocrinol
Kattner N, Hang Y, Krentz NAJ, Russell LA, Palmer M, Flaxman C, Plett N, Coulthard R, Al-Selwi Y, Dyson N, Honkanen-Scott M, Kim SK, Tiniakos D, Klöppel G, Richardson SJ, Shaw JAM.   +15 more
europepmc   +1 more source

Altered desensitization and internalization patterns of rodent versus human glucose‐dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The gut hormone glucose‐dependent insulinotropic polypeptide (GIP) signals via the GIP receptor (GIPR), resulting in postprandial potentiation of glucose‐stimulated insulin secretion. The translation of results from rodent studies to human studies has been challenged by the unexpected effects of GIPR‐targeting compounds.
Lærke Smidt Gasbjerg, Rasmus Syberg Rasmussen, Adrian Dragan, Peter Lindquist, Josefine Ulrikke Melchiorsen, Tomasz Maciej Stepniewski, Sine Schiellerup, Esther Karen Tordrup, Sarina Gadgaard, Hüsün Sheyma Kizilkaya, Sabine Willems, Yi Zhong, Yi Wang, Shane C. Wright, Volker M. Lauschke, Bolette Hartmann, Jens Juul Holst, Jana Selent, Mette Marie Rosenkilde   +18 more
wiley   +1 more source

Increased dietary protein stimulates amino acid catabolism via the gut microbiota and secondary bile acid production. [PDF]

Gut Microbes
Tobón-Cornejo S, Sanchez-Tapia M, Guizar-Heredia R, Velázquez Villegas L, Noriega LG, Furuzawa-Carballeda J, Hernández-Pando R, Vázquez-Manjarrez N, Granados-Portillo O, López-Barradas A, Rebollar-Vega R, Maya O, Miller AW, Serralde A, Guevara-Cruz M, Torres N, Tovar AR.   +16 more
europepmc   +1 more source

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel, Zeenat Zara, Alessandro Nicoli, Alexandra Steuer, Marta Lopez‐Balastegui, Jana Selent, Sanjai Karanth, Melanie Koehler, Antonella Ciancetta, Layara Akemi Abiko, Franz Hagn, Antonella Di Pizio   +11 more
wiley   +1 more source

Response to Comment on Foss-Freitas et al. Efficacy and Safety of Glucagon-Like Peptide 1 Agonists in a Retrospective Study of Patients With Familial Partial Lipodystrophy. Diabetes Care 2024;47:653-659. [PDF]

Diabetes Care
Foss-Freitas MC, Broome DT, Oral EA.
europepmc   +1 more source

Sex differences in the effects of maternal voluntary oral Cannabis consumption on the metabolic outcomes of high‐fat diet in adult offspring

British Journal of Pharmacology, EarlyView.
Sex differences in the effects of maternal voluntary editable Cannabis consumption on the metabolic phenotype of adult offspring on a high‐fat diet. Abstract Background and Purpose Given the recent rise in Cannabis legalisation, accessibility to Cannabis and consumption have increased during pregnancy. Therefore, there could be unintended developmental
Nada A. Sallam, Colleen S. Peterson, Samaa S. Kamar, Camila Saenz, Frank Visser, Stephanie L. Borgland   +5 more
wiley   +1 more source