Results 31 to 40 of about 214,982 (356)

Incretins today: multiple effects and therapeutic potential

Сахарный диабет, 2019
Glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) are the incretin hormones initially discovered in the 1960s. GIP and GLP-1 have gained great scientific interest due to their properties in increasing insulin secretion ...
Oksana V. Tsygankova, Varvara V. Veretyuk, Alexander S. Ametov   +2 more
doaj   +1 more source

Liver regeneration in dogs: Morphologic and chemical changes [PDF]

, 1978
Forty-four percent and 72% hepatectomy were carried out in dogs and the animals were sacrificed for biochemical and pathologic studies from 0.5 to 6 days later.
Antonio Francavilla, Arthur F. Jones, Bucher, Bucher, Burton, Duguay, Faloona, Farivar, Fisher, Giles, Grisham, Harper, Herbert, Holley, Joseph Benichou, Kendrick A. Porter, Krishna, Leffert, Leffert, Loud, Lowry, MacManus, Makman, Moody, Price, Salomon, Schneider, Short, Starzl, Starzl, Starzl, Thomas E. Starzl, Weinbren, White, Whittemore   +34 more
core   +1 more source

Foundational contributions of Svetlana Mojsov to the GLP-1 field [PDF]

Exploration of Drug Science
Biochemist Svetlana Mojsov, both as a graduate student at The Rockefeller University under the mentorship of Bruce Merrifield during the 1970s, and as an independent investigator at the Massachusetts General Hospital (MGH) during the 1980s, devised ...
George Barany, Michael J. Barany
doaj   +1 more source

Abnormal late postprandial glucagon response in type 1 diabetes is a function of differences in stimulated C-peptide concentrations

Frontiers in Endocrinology
BackgroundThe functional changes in alpha cells in patients with type 1 diabetes (T1D) with different residual beta cell functions remain poorly elucidated.
Lingyu Zhang, Lingyu Zhang, Yao Qin, Yiting Huang, Qizhen Hu, Qian Wu, Xing Wang, Mei Zhang   +7 more
doaj   +1 more source

Studies of the development of diabetic ketosis in the rat

Journal of Lipid Research, 1972
Plasma glucose, free fatty acid, ketone, and triglyceride concentrations were measured at frequent intervals after the administration of alloxan to rats. Hepatic triglyceride levels were determined in the same animals.
Jürgen M. Meier, J. Denis McGarry, Gerald R. Faloona, Roger H. Unger, Daniel W. Foster   +4 more
doaj   +1 more source

Optimal Regulation of Blood Glucose Level in Type I Diabetes using Insulin and Glucagon

, 2019
The Glucose-Insulin-Glucagon nonlinear model [1-4] accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes.
Della Rossa, Fabio, Klickstein, Isaac, Russell, John, Shirin, Afroza, Sorrentino, Francesco   +4 more
core   +4 more sources

Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial

Frontiers in Physiology, 2019
BackgroundInterleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise.
Louise Lang Lehrskov, Regitse Højgaard Christensen, Anne-Sophie Wedell-Neergaard, Grit Elster Legaard, Emma Dorph, Monica Korsager Larsen, Marie Henneberg, Natja Launbo, Sabrina Ravn Fagerlind, Sidsel Kofoed Seide, Stine Nymand, Maria Ball, Nicole Vinum, Camilla Dahl, Nicolai Jacob Wewer Albrechtsen, Nicolai Jacob Wewer Albrechtsen, Jens Juul Holst, Mathias Ried-Larsen, Jaya Birgitte Rosenmeier, Rikke Krogh-Madsen, Kristian Karstoft, Bente Klarlund Pedersen, Helga Ellingsgaard   +22 more
doaj   +1 more source

Case report: Fatal insulin overdose in a dog with type 1 diabetes mellitus—characteristics and successful management

Frontiers in Veterinary Science, 2023
Administering more than 10 times the therapeutic dose of insulin is extremely rare in diabetic dogs and is life threatening with hypoglycemia and seizures if not accompanied by appropriate treatment.
Jun-Hyeong Park, Ju-Hyun An, Se-Hoon Kim, Han-Sol Choi, Tae-Hyeon Kim, Ye-In Oh, Kyoung-Won Seo, Hwa-Young Youn   +7 more
doaj   +1 more source

The Physiology of Glucagon [PDF]

Journal of Diabetes Science and Technology, 2010
This short review outlines the physiology of glucagon in vivo, with an emphasis on its neural control, the author's area of interest. Glucagon is secreted from alpha cells, which are a minority of the pancreatic islet. Anatomically, they are down stream from the majority islet beta cells.
openaire   +2 more sources

Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses

, 2015
Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while ...
Hara, Manami, Hoang, Danh-Tai, Jo, Junghyo   +2 more
core   +3 more sources