Results 51 to 60 of about 114,692 (269)
Advanced Healthcare Materials, EarlyView.A novel hydrogel (HLBP) incorporating natural polysaccharides from goji berries is developed to enhance diabetic bone defect healing. The hydrogel efficiently scavenges ROS, improves osteogenic differentiation, and promotes in vivo bone regeneration. This strategy offers a biocompatible and localized approach, overcoming the challenges of traditional ...
Wenjie Zhong +9 more
wiley +1 more source
The relationship between glucose and the liver-alpha cell axis – A systematic review
Frontiers in Endocrinology, 2023 Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop.
Thomas Pixner +23 more
doaj +1 more source
Stable and flexible system for glucose homeostasis [PDF]
, 2013 Pancreatic islets, controlling glucose homeostasis, consist of \alpha, \beta, and \delta\ cells. It has been observed that \alpha\ and \beta\ cells generate out-of-phase synchronization in the release of glucagon and insulin, counter-regulatory hormones for increasing and decreasing glucose levels, while \beta\ and \delta\ cells produce in-phase ...
arxiv +1 more source
Advanced Materials, EarlyView.Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li +3 more
wiley +1 more source
A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man [PDF]
arXiv, 2022 We propose a whole-body model of the metabolism in man as well as a generalized approach for modeling metabolic networks. Using this approach, we are able to write a large metabolic network in a systematic and compact way. We demonstrate the approach using a whole-body model of the metabolism of the three macronutrients, carbohydrates, proteins and ...
arxiv
Advanced Materials, EarlyView.Wearable sensors, empowered by AI and smart materials, revolutionize healthcare by enabling intelligent disease diagnosis, personalized therapy, and seamless health monitoring without disrupting daily life. This review explores cutting‐edge advancements in smart materials and AI‐driven technologies that empower wearable sensors for diagnostics and ...
Shuwen Chen +14 more
wiley +1 more source
Multi-Step Optimal Tracking Control of Unknown Nonzero-Sum Games based on Least Squares and Linear Programming: An Application to a Fully-Automated, Dual-Hormone Artificial Pancreas [PDF]
arXiv, 2023 We consider the problem of optimal tracking control of unknown discrete-time nonlinear nonzero-sum games. The related state-of-art literature is mostly focused on Policy Iteration algorithms and multiple neural network approximation, which may lead to practical implementation challenges and high computational burden.
arxiv
Advanced Science, EarlyView.Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.scHeteroNet) is a novel graph neural network model that explicitly addresses heterophily in single‐cell sequencing data enabling accurate cell type annotation and novel cell type discovery. By leveraging heterophily‐aware message passing and novelty propagation mechanisms, scHeteroNet achieves superior performance in both cell annotation and detection ...
Jiacheng Liu +7 more
wiley +1 more source
ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022 Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen +3 more
wiley +1 more source