Results 161 to 170 of about 10,389 (214)

Shenqi Granules Ameliorate Cerebral Ischemia-Reperfusion Injury by Regulating Glucocerebrosidase and Uridine Metabolism in Microglia. [PDF]

Metabolites
Liu HX, Li YC, Liu CX, Yang MK, Zhou SY, Dong AA, Pei K, Wen SY.   +7 more
europepmc   +1 more source

New Antibodies to Advance Glucocerebrosidase Research

Journal of Parkinson’s Disease
openaire   +2 more sources

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease.

Brain, 2014
Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are the most frequent known genetic risk factor for Parkinson’s disease.
Nahid Tayebi, Ellen Sidransky, Woojin Scott Kim   +2 more
exaly   +3 more sources

Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients

Movement Disorders, 2017
Background: Reduced β-glucocerebrosidase activity was observed in postmortem brains of both GBA1 mutation carrier and noncarrier Parkinson's disease patients, suggesting that lower β-glucocerebrosidase activity is a key feature in the pathogenesis of PD.
Lucilla Parnetti, Anna Tasegian, Andrea Dardis   +2 more
exaly   +3 more sources

Glucocerebrosidase is shaking up the synucleinopathies [PDF]

Brain, 2014
The lysosomal enzyme glucocerebrosidase, encoded by the glucocerebrosidase gene, is involved in the breakdown of glucocerebroside into glucose and ceramide. Lysosomal build-up of the substrate glucocerebroside occurs in cells of the reticulo-endothelial system in patients with Gaucher disease, a rare lysosomal storage disorder caused by the recessively
Ellen Sidransky, Marina Siebert, Wendy Westbroek   +2 more
exaly   +3 more sources

Demonstration of the existence of a second, non-lysosomal glucocerebrosidase that is not deficient in Gaucher disease

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1993
In addition to the lysosomal glucocerebrosidase, a distinct beta-glucosidase that is also active towards glucosylceramide could be demonstrated in various human tissues and cell types.
Johannes Aerts, Joseph M Tager, Anneke Strijland   +2 more
exaly   +2 more sources