Results 91 to 100 of about 443,164 (406)
Frontiers in Immunology, 2017 Acute alcohol exposure suppresses cell inflammatory response. The underlying mechanism has not been fully defined. Here we report that alcohol was able to activate glucocorticoid receptor (GR) signaling in the absence of glucocorticoids (GCs) and ...
Hang Pong Ng +5 more
doaj +1 more source
Effects of clopidogrel and prednisone on platelet function in healthy dogs
Journal of Veterinary Internal Medicine, 2020 Background Glucocorticoids cause hypercoagulability, but it is unknown if they counteract clopidogrel's antiplatelet effects. Hypothesis/Objectives Determine the effects of clopidogrel and prednisone on platelet function. Animals Twenty‐four healthy dogs.
John Thomason +3 more
doaj +1 more source
Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
Frontiers in Cell and Developmental Biology, 2021 Chronic stress is common among cancer patients due to the psychological, operative, or pharmaceutical stressors at the time of diagnosis or during the treatment of cancers.
Wentao Tian +12 more
doaj +1 more source
New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation [PDF]
, 2013 Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor family of ...
Dejager, Lien +3 more
core +1 more source
Causal Mediation Analysis for Sparse and Irregular Longitudinal Data [PDF]
arXiv, 2020 Causal mediation analysis seeks to investigate how the treatment effect of an exposure on outcomes is mediated through intermediate variables. Although many applications involve longitudinal data, the existing methods are not directly applicable to settings where the mediator and outcome are measured on sparse and irregular time grids.
arxiv
Role of Glucocorticoids and Glucocorticoid Receptors in Glaucoma Pathogenesis
Cells, 2023 The glucocorticoid receptor (GR), including both alternative spliced isoforms (GRα and GRβ), has been implicated in the development of primary open-angle glaucoma (POAG) and iatrogenic glucocorticoid-induced glaucoma (GIG). POAG is the most common form of glaucoma, which is the leading cause of irreversible vision loss and blindness in the world ...
Pinkal D. Patel +2 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
Glucocorticoid-induced delayed fracture healing and impaired bone biomechanical properties in mice
Clinical Interventions in Aging, 2018 Yan-zhi Liu,1,2 Mohammed P Akhter,3 Xiang Gao,4 Xiao-yan Wang,2 Xiao-bei Wang,2 Gang Zhao,2 Xin Wei,2 Hao-jun Wu,4 Hang Chen,4 Dong Wang,2 Liao Cui1 1Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University ...
Liu YZ +10 more
doaj
Frontiers in Physiology, 2018 A rise in plasma triacylglycerol levels is a common physiological occurrence during late gestation and excess of glucocorticoids (GCs) has been shown to impair lipid metabolism.
Katia Motta +4 more
doaj +1 more source
Effect of adrenocorticotropic hormone infusion on circulating sclerostin levels
Endocrine Connections, 2021 Glucocorticoid use is the most common cause of secondary osteoporosis. Poor skeletal health related to glucocorticoid use is thought to involve inhibition of the Wnt/β-catenin signaling pathway, a key pathway in osteoblastogenesis.
Sarah Zaheer +8 more
doaj +1 more source