Results 161 to 170 of about 414,407 (362)

Editorial: Glucocorticoid and bone: Friend or foe

Frontiers in Endocrinology, 2022
Ulrike Baschant, Barbara Hauser, Barbara Hauser, Elizabeth Martha Winter   +3 more
doaj   +1 more source

Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells [PDF]

, 2011
G. Jan Zijlstra, Nick H.T. ten Hacken, Roland F. Hoffmann, A. J. M. van Oosterhout, Irene H. Heijink   +4 more
openalex   +1 more source

Overcoming reduced glucocorticoid sensitivity in airway disease:molecular mechanisms and therapeutic approaches [PDF]

, 2010
Abraham, Adcock, Ali, Allfrey, Auphan, Barnes, Barnes, Barnes, Barnes, Bartholome, Bartling, Bartling, Bateman, Beesley, Bergeron, Bhavsar, Bhavsar, Bourbeau, Cai, Calverley, Carmichael, Carrabino, Charmandari, Chen, Cho, Chung, Chung, Chung, Ciencewicki, Condliffe, Cosio, Cosio, Culpitt, Culpitt, Denslow, Duma, Evans, Ferreira, Fitzpatrick, Freedman, Gagliardo, Galasinski, Galliher-Beckley, Galliher-Beckley, Goleva, Gross, Gross, Hakonarson, Haller, Hew, Hogg, Hwang, Ian M. Adcock, Irusen, Ito, Ito, Ito, Ito, Ito, Ito, Jatakanon, John, John A. Marwick, Karp, Keatings, Kian Fan Chung, King, Kino, Kitagawa, Kleiman, Knoepfler, Konstan, Korn, Kovacs, Krstic, Kumar, Kumar, Kurashima, Laffargue, Langhoff, Lee, Lee, Lewis-Tuffin, Li, Li, Liu, Lu, Macedo, Mak, Mannino, Marone, Marwick, Marwick, Marwick, Marwick, Marwick, Matysiak, Meagher, Medicherla, Meja, Miller, Molnarfi, Moore, Murphy, Muselet-Charlier, Onda, Osoata, OʼSullivan, Pace, Patel, Pratt, Pujols, Pujols, Rahman, Rahman, Raia, Reichardt, Renda, Rennard, Rhen, Rogatsky, Rommel, Rottner, Rumora, Saccani, Sadhu, Sasaki, Schacke, Scheinman, Schermer, Sethi, Silverstein, Smith, Smolonska, Stav, Strickland, Suissa, Szatmuíry, Thomson, Tomlinson, Tuckermann, Tudhope, Ukena, Usmani, van Rensen, Verhaeghe, Ward, Ward, Wood, Wright, Young   +150 more
core   +1 more source

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Synthesis and structure–activity relationships of novel indazolyl glucocorticoid receptor partial agonists

, 2013
John L. Gilmore, James E. Sheppeck, Jim J. Wang, T. G. Murali Dhar, Cullen L. Cavallaro, Arthur M. Doweyko, Lorraine I. McKay, Mark Cunningham, Sium Habte, Steven G. Nadler, John H. Dodd, John E. Somerville, Joel C. Barrish   +12 more
openalex   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

SUN-451 A Randomized-Withdrawal, Placebo-Controlled, Phase 3 Study to Assess the Efficacy and Safety of Selective Glucocorticoid Receptor Antagonist, Relacorilant, in Patients with Cushing Syndrome (GRACE Study)

, 2019
Richard J. Auchus, James W. Findling, Andreas Moraitis   +2 more
openalex   +1 more source

Intracellular Regeneration of Glucocorticoids by11β-Hydroxysteroid Dehydrogenase (11β-HSD)-1 Plays a KeyRole in Regulation of the Hypothalamic-Pituitary-Adrenal Axis: Analysisof 11β-HSD-1-Deficient Mice**The Wellcome Trust supported this work through a program grant (to J.J.M. and J.R.S.) and a Career Development Fellowship (to M.C.H.). [PDF]

, 2001
Hayley J. Harris, Yuri Kotelevtsev, John J. Mullins, Jonathan R. Seckl, Megan C. Holmes   +4 more
openalex   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Reactive hemophagocytic syndromes in children with rheumatic diseases

Rheumatology, 2011
Reactive haemophagocytic syndrome (RHPS), also calledmacrophage activation syndrome (MAS), is a serious complicationof viral, rheumatic and malignant diseases, thought to be causedby the excessive activation of T lymphocytes and macrophages.MAS is ...
Piotr Gietka, Anna Wieteska-Klimczak, Anna Smorczewska-Kiljan, Lidia Rutkowska-Sak, Janusz Książyk   +4 more
doaj