Results 221 to 230 of about 248,217 (267)
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Biochemical Pharmacology, 2002
Glucocorticoids are the most effective anti-inflammatory agents known. However, the use of these powerful molecules is plagued by a host of serious, sometimes life-threatening side-effects. The search for new compounds that maintain the efficacy of the steroids without some of the side-effects has entered a new phase.
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Glucocorticoids are the most effective anti-inflammatory agents known. However, the use of these powerful molecules is plagued by a host of serious, sometimes life-threatening side-effects. The search for new compounds that maintain the efficacy of the steroids without some of the side-effects has entered a new phase.
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The Journal of Steroid Biochemistry and Molecular Biology, 1992
Glucocorticoid hormones are secreted uniquely from the zona fasciculata of the adrenal cortex, with marked circadian variation in basal levels and acute elevation in response to stress. Glucocorticoid receptors are almost ubiquitously distributed, and mediate a wide range of tissue-specific responses; in addition to classical, [3H]dexamethasone-binding
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Glucocorticoid hormones are secreted uniquely from the zona fasciculata of the adrenal cortex, with marked circadian variation in basal levels and acute elevation in response to stress. Glucocorticoid receptors are almost ubiquitously distributed, and mediate a wide range of tissue-specific responses; in addition to classical, [3H]dexamethasone-binding
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Cochrane Database of Systematic Reviews, 2011
Since the initial publication of this systematic review in 1997, several randomized trials examining the benefit of glucocorticoids have been published. The objective of this review is to provide evidence to guide clinicians in their treatment of patients with croup by determining the effectiveness of glucocorticoids and to identify areas requiring ...
Kelly F, Russell +4 more
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Since the initial publication of this systematic review in 1997, several randomized trials examining the benefit of glucocorticoids have been published. The objective of this review is to provide evidence to guide clinicians in their treatment of patients with croup by determining the effectiveness of glucocorticoids and to identify areas requiring ...
Kelly F, Russell +4 more
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Journal of Asthma, 1994
Glucocorticoids act on calcium metabolism at many levels to produce osteoporosis, the major pathogenic effect probably being an inhibition of bone formation. In men, this is likely to be contributed to by a dose-related reduction in circulating testosterone concentrations.
I R, Reid, A G, Veale, J T, France
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Glucocorticoids act on calcium metabolism at many levels to produce osteoporosis, the major pathogenic effect probably being an inhibition of bone formation. In men, this is likely to be contributed to by a dose-related reduction in circulating testosterone concentrations.
I R, Reid, A G, Veale, J T, France
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Annales d'Endocrinologie, 2018
Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the most frequent cause of osteoporosis in young people. Bone loss and fracture risk increase rapidly after the initiation of corticosteroid therapy and are proportional to dose and treatment duration.
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Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the most frequent cause of osteoporosis in young people. Bone loss and fracture risk increase rapidly after the initiation of corticosteroid therapy and are proportional to dose and treatment duration.
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2002
Corticosteroids are highly effective anti-inflammatory therapy in asthma, and the molecular mechanisms involved in suppression of allergic inflammation are now better understood (Barnes 1998, 2001). Corticosteroids are effective clinically because they block many of the inflammatory pathways that are abnormally activated in asthma and they have a very ...
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Corticosteroids are highly effective anti-inflammatory therapy in asthma, and the molecular mechanisms involved in suppression of allergic inflammation are now better understood (Barnes 1998, 2001). Corticosteroids are effective clinically because they block many of the inflammatory pathways that are abnormally activated in asthma and they have a very ...
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Glucocorticoids and Lipocortin
1989One of the responses of an animal to injury, infection or other stresses is the release from the adrenal cortex of glucocorticosteroids(GCs). In humans this is predominantly hydrocortisone (cortisol), but other animals may release different but related steroids. For a long while it was believed that steroids were in some way involved in the mounting of
S. H. Peers, R. J. Flower
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1989
More than 30 years ago the first report concerning the therapeutic use of glucocorticoids appeared. Even if the pediatrician is aware of the large number of clinical and experimental studies that have accumulated during the past three decades he is still faced with the uncertainties of corticosteroid therapy in children’s diseases especially with ...
D, Reinhardt, M, Griese
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More than 30 years ago the first report concerning the therapeutic use of glucocorticoids appeared. Even if the pediatrician is aware of the large number of clinical and experimental studies that have accumulated during the past three decades he is still faced with the uncertainties of corticosteroid therapy in children’s diseases especially with ...
D, Reinhardt, M, Griese
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Aging Clinical and Experimental Research, 1995
Information on the role of glucocorticoids in the aging of vertebrate species is reviewed. There is strong evidence that elevated plasma glucocorticoid levels have a causal role in the rapid deterioration following reproduction in semelparous vertebrate species.
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Information on the role of glucocorticoids in the aging of vertebrate species is reviewed. There is strong evidence that elevated plasma glucocorticoid levels have a causal role in the rapid deterioration following reproduction in semelparous vertebrate species.
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