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Glucocorticoid-Induced Osteoporosis
Hormone Research in Paediatrics, 2003Osteoporosis is a common and serious complication of glucocorticoid therapy, resulting in increased risk of fragility fractures. Recent studies indicate that fracture risk is increased even at low doses of glucocorticoids and that this increased risk is seen soon after the commencement of glucocorticoid therapy.
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Glucocorticoid-induced osteoporosis
Best Practice & Research Clinical Endocrinology & Metabolism, 1998Glucocorticoid drugs interact with bone metabolism at many levels, but their principal action is to reduce osteoblast number and bone matrix synthesis. Virtually all patients receiving glucocorticoids in doses above 5 mg per day lose bone, the amount lost being dependent on the cumulative steroid dose.
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Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
Nature, 2021Chunyou Mao, Peng Xiao, Yi Jiang
exaly
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions
Nature Reviews Endocrinology, 2022Carolyn L Cummins
exaly
Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment
Nature Reviews Endocrinology, 2020Pojchong Chotiyarnwong, E V Mccloskey
exaly

