Results 361 to 370 of about 460,157 (392)
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2019
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolas C, Nicolaides +1 more
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Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolas C, Nicolaides +1 more
openaire +2 more sources
Clinical Endocrinology, 2004
Summaryobjective To measure glucocorticoid receptor gamma (GRγ) expression in transformed lymphocytes from individuals of known GR gene haplotype. Recently, a glucocorticoid receptor haplotype (GAT) has been described that associates with increased sensitivity to dexamethasone.
Stevens, Adam +2 more
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Summaryobjective To measure glucocorticoid receptor gamma (GRγ) expression in transformed lymphocytes from individuals of known GR gene haplotype. Recently, a glucocorticoid receptor haplotype (GAT) has been described that associates with increased sensitivity to dexamethasone.
Stevens, Adam +2 more
openaire +4 more sources
Glucocorticoids and depression
Best Practice & Research Clinical Endocrinology & Metabolism, 1999Depression has been associated with impaired mineralocorticoid receptor function, restrained glucocorticoid receptor feedback at the level of the hypothalamic-pituitary-adrenal (HPA) axis, raised cortisol level and increased corticotropin-releasing factor activity, which may act in concert to induce the signs and symptoms of the disorder.
Steckler, T, Holsboer, F, Reul, J M
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Glucocorticoids and Lipocortin
1989One of the responses of an animal to injury, infection or other stresses is the release from the adrenal cortex of glucocorticosteroids(GCs). In humans this is predominantly hydrocortisone (cortisol), but other animals may release different but related steroids. For a long while it was believed that steroids were in some way involved in the mounting of
S. H. Peers, R. J. Flower
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1989
More than 30 years ago the first report concerning the therapeutic use of glucocorticoids appeared. Even if the pediatrician is aware of the large number of clinical and experimental studies that have accumulated during the past three decades he is still faced with the uncertainties of corticosteroid therapy in children’s diseases especially with ...
M. Griese, D. Reinhardt
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More than 30 years ago the first report concerning the therapeutic use of glucocorticoids appeared. Even if the pediatrician is aware of the large number of clinical and experimental studies that have accumulated during the past three decades he is still faced with the uncertainties of corticosteroid therapy in children’s diseases especially with ...
M. Griese, D. Reinhardt
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Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment
Nature Reviews Endocrinology, 2020P. Chotiyarnwong, E. McCloskey
semanticscholar +1 more source
Aging Clinical and Experimental Research, 1995
Information on the role of glucocorticoids in the aging of vertebrate species is reviewed. There is strong evidence that elevated plasma glucocorticoid levels have a causal role in the rapid deterioration following reproduction in semelparous vertebrate species.
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Information on the role of glucocorticoids in the aging of vertebrate species is reviewed. There is strong evidence that elevated plasma glucocorticoid levels have a causal role in the rapid deterioration following reproduction in semelparous vertebrate species.
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1979
Steroids in general and glucocorticoids in particular affect lysosomes in various ways. The explanation of these effects remains in dispute, however. Theories include the view that steroids interact directly with lysosomal membranes, that steroids provoke induced changes in lysosomes, and that classical steroid receptors originate in lysosomes ...
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Steroids in general and glucocorticoids in particular affect lysosomes in various ways. The explanation of these effects remains in dispute, however. Theories include the view that steroids interact directly with lysosomal membranes, that steroids provoke induced changes in lysosomes, and that classical steroid receptors originate in lysosomes ...
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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
Nature, 1980A. Wyllie
semanticscholar +1 more source
2015
The lung is a major clinical target of glucocorticoid-based therapeutics, and GR signaling has broad effects on respiratory physiology and inflammation. During lung development, expression of GR in the mesenchyme is required for normal terminal alveolar epithelial differentiation.
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The lung is a major clinical target of glucocorticoid-based therapeutics, and GR signaling has broad effects on respiratory physiology and inflammation. During lung development, expression of GR in the mesenchyme is required for normal terminal alveolar epithelial differentiation.
openaire +3 more sources