Results 371 to 380 of about 443,164 (406)
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Science, 1987
Low-stringency hybridization with human glucocorticoid receptor (hGR) complementary DNA was used to isolate a new gene encoding a predicted 107-kilodalton polypeptide.
J. Arriza +8 more
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Low-stringency hybridization with human glucocorticoid receptor (hGR) complementary DNA was used to isolate a new gene encoding a predicted 107-kilodalton polypeptide.
J. Arriza +8 more
semanticscholar +1 more source
2002
Corticosteroids are highly effective anti-inflammatory therapy in asthma, and the molecular mechanisms involved in suppression of allergic inflammation are now better understood (Barnes 1998, 2001). Corticosteroids are effective clinically because they block many of the inflammatory pathways that are abnormally activated in asthma and they have a very ...
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Corticosteroids are highly effective anti-inflammatory therapy in asthma, and the molecular mechanisms involved in suppression of allergic inflammation are now better understood (Barnes 1998, 2001). Corticosteroids are effective clinically because they block many of the inflammatory pathways that are abnormally activated in asthma and they have a very ...
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Glucocorticoids and glucocorticoid receptors: mediators of fatigue?
Acta Neuropsychiatrica, 2003Fatigue is a common problem; when chronic and disabling, subjects can be categorized as having chronic fatigue syndrome (CFS). Whilst it is most likely a multifactorial condition of biopsychosocial origin, the nature of the pathophysiological component remains unclear.
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Clinical Endocrinology, 2004
Summaryobjective To measure glucocorticoid receptor gamma (GRγ) expression in transformed lymphocytes from individuals of known GR gene haplotype. Recently, a glucocorticoid receptor haplotype (GAT) has been described that associates with increased sensitivity to dexamethasone.
Stevens, Adam +2 more
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Summaryobjective To measure glucocorticoid receptor gamma (GRγ) expression in transformed lymphocytes from individuals of known GR gene haplotype. Recently, a glucocorticoid receptor haplotype (GAT) has been described that associates with increased sensitivity to dexamethasone.
Stevens, Adam +2 more
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2019
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolas C, Nicolaides +1 more
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Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolas C, Nicolaides +1 more
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Glucocorticoids and depression
Best Practice & Research Clinical Endocrinology & Metabolism, 1999Depression has been associated with impaired mineralocorticoid receptor function, restrained glucocorticoid receptor feedback at the level of the hypothalamic-pituitary-adrenal (HPA) axis, raised cortisol level and increased corticotropin-releasing factor activity, which may act in concert to induce the signs and symptoms of the disorder.
Steckler, T, Holsboer, F, Reul, J M
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Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones.
Science, 1986The production and action of immunoregulatory cytokines, including interleukin-1 (IL-1), are inhibited by glucocorticoid hormones in vivo and in vitro. Conversely, glucocorticoid blood levels were increased by factors released by human leukocytes exposed
H. Besedovsky +3 more
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Glucocorticoids and Lipocortin
1989One of the responses of an animal to injury, infection or other stresses is the release from the adrenal cortex of glucocorticosteroids(GCs). In humans this is predominantly hydrocortisone (cortisol), but other animals may release different but related steroids. For a long while it was believed that steroids were in some way involved in the mounting of
S. H. Peers, R. J. Flower
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1989
More than 30 years ago the first report concerning the therapeutic use of glucocorticoids appeared. Even if the pediatrician is aware of the large number of clinical and experimental studies that have accumulated during the past three decades he is still faced with the uncertainties of corticosteroid therapy in children’s diseases especially with ...
M. Griese, D. Reinhardt
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More than 30 years ago the first report concerning the therapeutic use of glucocorticoids appeared. Even if the pediatrician is aware of the large number of clinical and experimental studies that have accumulated during the past three decades he is still faced with the uncertainties of corticosteroid therapy in children’s diseases especially with ...
M. Griese, D. Reinhardt
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Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment
Nature Reviews Endocrinology, 2020P. Chotiyarnwong, E. McCloskey
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