Results 51 to 60 of about 62,040 (256)

Korean red ginseng extract prevents bone loss in an oral model of glucocorticoid induced osteoporosis in mice

Frontiers in Pharmacology
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut ...
Nicholas J. Chargo, Nicholas J. Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R. McCabe, Laura R. McCabe, Narayanan Parameswaran, Narayanan Parameswaran   +10 more
doaj   +1 more source

A Review of Postpartum Depression: Focused on Psychoneuroimmunological Interaction [PDF]

Korean Journal of Women Health Nursing, 2015
PURPOSE: The purpose of this review was to describe a psychoneuroimmunology (PNI) framework for postpartum depression (PPD) and discuss its implications for nursing research and practice for postpartum women.
Yunmi Kim, Sukhee Ahn
doaj   +1 more source

Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China

Emerging Infectious Diseases, 2022
Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation.
Wenchao Zhang, Mei Yin, Wei Li, Nana Xu, Haining Lu, Weidong Qin, Hui Han, Chen Li, Dawei Wu, Hao Wang   +9 more
doaj   +1 more source

Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro [PDF]

, 2012
Introduction: Despite the excellent anti-inflammatory and immunosuppressive action of glucocorticoids (GCs), their use for the treatment of inflammatory bowel disease (IBD) still carries significant risks in terms of frequently occurring severe side ...
Kerstin C Reuter, Jürgen Stein, Axel U Dignass, Stefan M Loitsch, Dieter Steinhilber (182458), Reuter, Kerstin C., Dignaß, Axel Uwe, Kerstin C. Reuter (186426), Dieter Steinhilber, Stefan M. Loitsch (186433), Loitsch, Stefan Marcel, Stein, Jürgen, Axel U. Dignass (186440), Steinhilber, Dieter, Jürgen Stein (186447)   +14 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid[S]

Journal of Lipid Research, 2013
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mediates glucocorticoid activation and is currently considered as therapeutic target to treat metabolic diseases; however, biomarkers to assess its activity in vivo are still lacking.
Carlos A. Penno, Stuart A. Morgan, Anna Vuorinen, Daniela Schuster, Gareth G. Lavery, Alex Odermatt   +5 more
doaj   +1 more source

Network Meta-Analysis of Different Intravenous Glucocorticoid Regimes for the Treatment of Graves’ Orbitopathy

Frontiers in Pharmacology, 2022
Background: Intravenous glucocorticoid (GC) has been proposed to treat moderately severe Graves’ orbitopathy (GO); however, the optimal regime remains debatable.
Jun Jia, Jingjian Dong, Lin Deng
doaj   +1 more source

GLUCOCORTICOID THERAPY

Medicine, 1976
1. There is a poor relationship between the circulating half-life a glucocorticoid and either its potency or its duration of action. Many actions of a glucocorticoid have unequal durations. The duration of action varies with the dose. 2. The presence of biological activity as a glucocorticoid depends on the presence of a hydroxyl group at carbon number
openaire   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source