Results 61 to 70 of about 415,661 (358)

11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]

, 2009
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
A. Yu, Abdallah, Aguirre, Araki, C. Lenaghan, D. Laber, D. M. Smith, Danielsson, Djurhuus, Draznin, Fraser, G. Convey, G. G. Lavery, Geraghty, Giorgino, Giorgino, Giorgino, Hanada, I. J. Bujalska, J. K. Sethi, J. W. Tomlinson, Jang, K. Hegyi, Kido, Kim, L. L. Gathercole, Larsson, Liu, M. Sherlock, M  ssig, P. M. Stewart, R. Mayers, S. A. Morgan, Saad, van Staa, Watson, Whorwood, Zhang   +37 more
core   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Expression of long noncoding RNA Xist is induced by glucocorticoids

Frontiers in Endocrinology, 2022
Glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive agents. However, their clinical usage is limited by severe multisystemic side effects.
Yun Su, Xing Chen, Hongyan Zhou, Hongyan Zhou, Sean Shaw, Jie Chen, Carlos M. Isales, Carlos M. Isales, Jing Zhao, Xingming Shi, Xingming Shi   +10 more
doaj   +1 more source

GLUCOCORTICOID THERAPY

Medicine, 1976
1. There is a poor relationship between the circulating half-life a glucocorticoid and either its potency or its duration of action. Many actions of a glucocorticoid have unequal durations. The duration of action varies with the dose. 2. The presence of biological activity as a glucocorticoid depends on the presence of a hydroxyl group at carbon number
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Korean red ginseng extract prevents bone loss in an oral model of glucocorticoid induced osteoporosis in mice

Frontiers in Pharmacology
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut ...
Nicholas J. Chargo, Nicholas J. Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R. McCabe, Laura R. McCabe, Narayanan Parameswaran, Narayanan Parameswaran   +10 more
doaj   +1 more source

A Review of Postpartum Depression: Focused on Psychoneuroimmunological Interaction [PDF]

Korean Journal of Women Health Nursing, 2015
PURPOSE: The purpose of this review was to describe a psychoneuroimmunology (PNI) framework for postpartum depression (PPD) and discuss its implications for nursing research and practice for postpartum women.
Yunmi Kim, Sukhee Ahn
doaj   +1 more source

Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China

Emerging Infectious Diseases, 2022
Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation.
Wenchao Zhang, Mei Yin, Wei Li, Nana Xu, Haining Lu, Weidong Qin, Hui Han, Chen Li, Dawei Wu, Hao Wang   +9 more
doaj   +1 more source

Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay. [PDF]

, 2017
BackgroundGlucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors.
Block, Thaddeus S, Lynch, Frank J, Munster, Pamela N, Murphy, Tiffany I, Nguyen, Dat P   +4 more
core   +2 more sources

Glucocorticoid Resistance

, 2019
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolaides, N.C., Charmandari, E.
openaire   +3 more sources