Results 31 to 40 of about 62,040 (256)

A Core Omnigenic Non-coding Trait Governing Dex-Induced Osteoporotic Effects Identified Without DEXA

Frontiers in Pharmacology, 2021
Iatrogenic glucocorticoid (GC)-induced osteoporosis (GIO) is an idiosyncratic form of secondary osteoporosis. Genetic predisposition among individuals may give rise to variant degree of phenotypic changes but there has yet been a documented unified ...
Li Lu, Yanzhen Cai, Xiaoling Luo, Zhangting Wang, Sin Hang Fung, Huanhuan Jia, Huanhuan Jia, Chi Lam Yu, Wai Yee Chan, Kai Kei Miu, Wende Xiao   +10 more
doaj   +1 more source

Association Between NR3C1 Mutations and Glucocorticoid Resistance in Children With Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2021
Treatment outcomes in children with acute lymphoblastic leukemia (ALL) have been improved substantially, with a cure rate exceeding 80% using conventional therapy.
Haiyan Liu, Ziping Li, Ziping Li, Fei Qiu, Chunjie Li, Xiaojing Lin, Yingyi He, Maoxiang Qian, Yuanbin Song, Hui Zhang   +9 more
doaj   +1 more source

Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ)

Frontiers in Immunology, 2022
SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for SLE treatment but are associated with detrimental metabolic effects.
Wendy Dankers, Melissa Northcott, Taylah Bennett, Akshay D’Cruz, Rochelle Sherlock, Linden J. Gearing, Paul Hertzog, Brendan Russ, Iolanda Miceli, Sebastian Scheer, Maki Fujishiro, Kunihiro Hayakawa, Keigo Ikeda, Keigo Ikeda, Eric F. Morand, Sarah A. Jones   +15 more
doaj   +1 more source

Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2 [PDF]

, 2010
Context: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder as a result of mutation in genes encoding either the ACTH receptor [melanocortin 2 receptor (MC2R)] or its accessory protein [melanocortin 2 receptor accessory ...
Metherell, LA, Chung, TTLL, Clark, AJ, Chung, TT, Chan, LF, Clark, AJL   +5 more
core   +1 more source

Piper sarmentosum Effects on 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme in Serum and Bone in Rat Model of Glucocorticoid-Induced Osteoporosis

Molecules, 2016
Glucocorticoid-induced osteoporosis is one of the common causes of secondary osteoporosis. Piper sarmentosum (Ps) extract possesses antioxidant and anti-inflammatory activities.
Siti Fadziyah Mohamad Asri, Elvy Suhana Mohd Ramli, Ima Nirwana Soelaiman, Muhamad Alfakry Mat Noh, Abdul Hamid Abdul Rashid, Farihah Suhaimi   +5 more
doaj   +1 more source

Clinical Features of Hypersensitivity Pneumonitis in Children: A Single Center Study

Frontiers in Pediatrics, 2022
BackgroundHypersensitivity pneumonia (HP) is an interstitial lung disease (ILD) mainly involving small airways and lung parenchyma that is caused by the inhalation of antigens in susceptible people to stimulate the body's immune response.MethodsA total ...
Feizhou Zhang, Tongyu Yang, Zhixuan Liu, Xuan Jia, Li Yang, Lei Wu, Lanfang Tang   +6 more
doaj   +1 more source

Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection

Pathogens, 2022
Background: Corneal infection of Colletotrichum gloeosporioides is uncommon and usually limited to the anterior stroma. However, we observed a case of corneal stromal perforation caused by this fungus under a compromised condition.
Kazuki Imai, Takayoshi Sumioka, Hiroki Iwanishi, Yukihisa Takada, Shin’ichi Murata, Ryuta Iwamoto, Yuka Okada, Shizuya Saika   +7 more
doaj   +1 more source

Diagnosis and approach to glucocorticoid-induced adrenal insufficiency and glucocorticoid withdrawal syndrome

Journal of Education, Health and Sport
Introduction and purpose: Primary adrenal insufficiency can result from diseases affecting the adrenal glands, while secondary adrenal insufficiency is caused by suppression of the hypothalamic-pituitary-adrenal axis.
Aleksandra Kiełczewska, Grzegorz Szcześniak, Anna Kiełczewska   +2 more
doaj   +1 more source

Diagnosis and treatment of transnasal endoscopic optic canal decompression for traumatic optic neuropathy

Frontiers in Neuroscience, 2023
ObjectiveTo investigate the clinical efficacy and prognostic factors of transnasal endoscopic optic decompression in the treatment of traumatic optic neuropathy (TON).MethodsA retrospective analysis was performed on 13 TON patients in The Seventh ...
Xiang Tu, Cheng Xiong, Hui Qi, Yangming Ou, Jing Rao, Yueqi Sun, Yunping Fan, Guiqin Liu   +7 more
doaj   +1 more source

Activation of the Nrf2/HO-1 pathway restores N-acetylcysteine-induced impairment of the hypothalamus-pituitary-adrenal axis negative feedback by up-regulating GRα expression and down-regulating GRβ expression into pituitary glands

Frontiers in Endocrinology
We previously showed that antioxidants induced an impairment of negative feedback of the hypothalamus-pituitary-adrenal (HPA) axis in rats, in parallel to a down-regulation of the glucocorticoid receptor (GR) and nuclear factor erythroid 2-related factor
Amanda Silva Chaves, Raíssa Duarte Ventura, Maria Florencia Pacini, Nathalia Santos Magalhães, Patrícia Machado Rodrigues e Silva, Marco Aurélio Martins, Ana Rosa Pérez, Vinicius Frias Carvalho, Vinicius Frias Carvalho, Vinicius Frias Carvalho, Vinicius Frias Carvalho   +10 more
doaj   +1 more source