Results 31 to 40 of about 415,661 (358)

Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis

Biomolecules, 2021
Glucocorticoids (GCs), a class of corticosteroids produced by the adrenal cortex in response to stress, exert obesity-promoting effects. Although adaptive thermogenesis has been considered an effective approach to counteract obesity, whether GCs play a ...
Liping Luo, Lu Wang, Yan Luo, Estevan Romero, Xin Yang, Meilian Liu   +5 more
doaj   +1 more source

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I, Chen, Tzu-Chieh, Costello, Damian E, Kuo, Taiyi, Lee, Rebecca A, Li, Mei-Lan, Mar, Darryl J, Nomura, Daniel K, Wang, Jen-Chywan   +8 more
core   +1 more source

Clinical diagnosis and treatment recommendations for immune checkpoint inhibitor‐related adverse reactions in the nervous system

Thoracic Cancer, 2020
Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incidence rate is 0.1%–12% and 80% of nervous system adverse reactions occur within the first four months of application.
Jiayu Shi, Jingwen Niu, Dongchao Shen, Mingsheng Liu, Ying Tan, Yi Li, Yangyu huang, Liying Cui, Yuzhou Guan, Li Zhang   +9 more
doaj   +1 more source

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling

Frontiers in Endocrinology, 2023
As a treatment for various immune-mediated diseases, the use of glucocorticoids as anti-inflammatory and immunosuppressive agents is common practice.
Lisa Fleischhauer, Lisa Fleischhauer, Alejandra Cristina López-Delgado, Alejandra Cristina López-Delgado, Karina Geurtzen, Karina Geurtzen, Franziska Knopf, Franziska Knopf   +7 more
doaj   +1 more source

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. [PDF]

, 2016
Based on molecular mechanisms and physiologic data, a strong association has been established between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS).
Meduri, Gianfranco Umberto, Schwingshackl, Andreas   +1 more
core   +1 more source

Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The contribution of glucocorticoids to sexual dimorphism in the heart is essentially unknown. Therefore, we sought to determine the sexually dimorphic actions of glucocorticoid signaling in cardiac function and gene expression.
Diana Cruz‐Topete, Robert H. Oakley, Natalie G. Carroll, Bo He, Page H. Myers, Xiaojiang Xu, Megan N. Watts, Krystle Trosclair, Edward Glasscock, Paari Dominic, John A. Cidlowski   +10 more
doaj   +1 more source

Case Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy

Frontiers in Immunology, 2023
Neuropsychiatric systemic lupus erythematosus (NPSLE) is the diagnosis that rheumatologists most often need to consider when a patient with lupus presents with neurologic symptoms.
Jialin Zhang, Jialin Zhang, Xiaodong Wu, Jing Xue, Lei Liu   +4 more
doaj   +1 more source

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads [PDF]

, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Atucha, Avenant, Baiula, Barnes, Bauer, Baumer, Beck, Berk, Biggadike, Bledsoe, Bonvini, Carson, Cheatham, Chen, Corne, De Bosscher, De Bosscher, De Bosscher, De Vos, Desmet, Desmet, Engel, Garuti, Helsens, Lieber, Liu, Madauss, Mcmaster, Meijsing, Newton, Newton, Perkins, Proksch, Ratman, Rehman, Reichardt, Rhen, Roskoski, Ryabtsova, Schacke, Schacke, Schacke, Schacke, Schindelin, Schuttelkopf, Shafiee, Simons, Simons, Simons, Singh, Sundahl, Touw, Trott, Vanden Berghe, Vanden Berghe, Vandevyver, Vane, Vanhaesebroeck, Verschuuren, Vettorazzi, Wang, Werkstrom   +61 more
core   +2 more sources

Bromodomain Protein BRD4 Accelerates Glucocorticoid Dysregulation of Bone Mass and Marrow Adiposis by Modulating H3K9 and Foxp1

Cells, 2020
Glucocorticoid provokes bone mass loss and fatty marrow, accelerating osteoporosis development. Bromodomain protein BRD4, an acetyl–histone-binding chromatin reader, regulates stem cell and tissue homeostasis.
Feng-Sheng Wang, Yu-Shan Chen, Jih-Yang Ko, Chung-Wen Kuo, Huei-Jing Ke, Chin-Kuei Hsieh, Shao-Yu Wang, Pei-Chen Kuo, Holger Jahr, Wei-Shiung Lian   +9 more
doaj   +1 more source