Results 21 to 30 of about 62,040 (256)

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring [PDF]

, 1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying this link are unknown but fetal exposure to excess glucocorticoids has been implicated, The fetus is normally protected from ...
Kenyon, C J, Seckl, J R, C J Kenyon, Burchell, A, R S Lindsay, A Burchell, J R Seckl, Lindsay, R S, M J Nyirenda, Nyirenda, M J   +9 more
core   +1 more source

Clinical diagnosis and treatment recommendations for immune checkpoint inhibitor‐related adverse reactions in the nervous system

Thoracic Cancer, 2020
Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incidence rate is 0.1%–12% and 80% of nervous system adverse reactions occur within the first four months of application.
Jiayu Shi, Jingwen Niu, Dongchao Shen, Mingsheng Liu, Ying Tan, Yi Li, Yangyu huang, Liying Cui, Yuzhou Guan, Li Zhang   +9 more
doaj   +1 more source

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]

, 2006
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Buskens, E.; id_orcid, Jacobs, J.W.G., Laan, R.F., Laan, R.F.J.M., Oostveen, A.C., Lems, W.F., Dijkmans, B.A., Bruyn, G.A.W., Huisman, A.M., Jacobs, J.W., Hofbauer, L.C., Laet, C.E. de, Algra, A., Dijkmans, B.A.C., de Laet, C.E.D., Bruyn, G.A., Geusens, P.P., de Nijs, R.N., Buskens, E., Bijlsma, J.W., Bijlsma, J.W.J., Geusens, P.P.M.M., Laan, R.F.J., Huisman, A., Nijs, R.N. de, Oostveen, A.C.M., de Nijs, R.N.J.   +26 more
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Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain [PDF]

, 2012
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin and
Linthorst, Astrid C E, Droste, Susanne K, Reul, Johannes M H M, Qian, Xiaoxiao, Lightman, Stafford L   +4 more
core   +1 more source

Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling

Frontiers in Endocrinology, 2023
As a treatment for various immune-mediated diseases, the use of glucocorticoids as anti-inflammatory and immunosuppressive agents is common practice.
Lisa Fleischhauer, Lisa Fleischhauer, Alejandra Cristina López-Delgado, Alejandra Cristina López-Delgado, Karina Geurtzen, Karina Geurtzen, Franziska Knopf, Franziska Knopf   +7 more
doaj   +1 more source

Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The contribution of glucocorticoids to sexual dimorphism in the heart is essentially unknown. Therefore, we sought to determine the sexually dimorphic actions of glucocorticoid signaling in cardiac function and gene expression.
Diana Cruz‐Topete, Robert H. Oakley, Natalie G. Carroll, Bo He, Page H. Myers, Xiaojiang Xu, Megan N. Watts, Krystle Trosclair, Edward Glasscock, Paari Dominic, John A. Cidlowski   +10 more
doaj   +1 more source

Case Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy

Frontiers in Immunology, 2023
Neuropsychiatric systemic lupus erythematosus (NPSLE) is the diagnosis that rheumatologists most often need to consider when a patient with lupus presents with neurologic symptoms.
Jialin Zhang, Jialin Zhang, Xiaodong Wu, Jing Xue, Lei Liu   +4 more
doaj   +1 more source

The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]

, 2007
Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C, Miner, JN, Farquharson, C; id_orcid, Owen, H C, Miner, J N, Ahmed, S F, Ahmed, SF, Owen, HC   +7 more
core   +1 more source

An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation [PDF]

, 2010
Includes bibliographical references (leaves 134-151).The glucocorticoid receptor (GR) is a ligand-activated transcription factor which, due to its central role in anti-inflammatory responses, is a target of many therapeutically prescribed drugs.
Hadley, Katie Emma
core   +1 more source

Bromodomain Protein BRD4 Accelerates Glucocorticoid Dysregulation of Bone Mass and Marrow Adiposis by Modulating H3K9 and Foxp1

Cells, 2020
Glucocorticoid provokes bone mass loss and fatty marrow, accelerating osteoporosis development. Bromodomain protein BRD4, an acetyl–histone-binding chromatin reader, regulates stem cell and tissue homeostasis.
Feng-Sheng Wang, Yu-Shan Chen, Jih-Yang Ko, Chung-Wen Kuo, Huei-Jing Ke, Chin-Kuei Hsieh, Shao-Yu Wang, Pei-Chen Kuo, Holger Jahr, Wei-Shiung Lian   +9 more
doaj   +1 more source