Results 21 to 30 of about 258,084 (317)

Abnormality of Aldosterone and Cortisol Late Pathways in Glucocorticoid-Remediable Aldosteronism. [PDF]

, 1994
Patients with glucocorticoid-remediable aldosteronism (GRA) possess a chimeric gene resulting from fusion of the genes encoding steroid aldosterone synthase and 11 beta-hydroxylase.
Boscaro, Marco, Kuhnle, Ursula, KUHNLE U, Fallo, Francesco, Sonino, Nicoletta   +4 more
core   +1 more source

Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis

Biomolecules, 2021
Glucocorticoids (GCs), a class of corticosteroids produced by the adrenal cortex in response to stress, exert obesity-promoting effects. Although adaptive thermogenesis has been considered an effective approach to counteract obesity, whether GCs play a ...
Liping Luo, Lu Wang, Yan Luo, Estevan Romero, Xin Yang, Meilian Liu   +5 more
doaj   +1 more source

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]

, 2006
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Buskens, E.; id_orcid, Jacobs, J.W.G., Laan, R.F., Laan, R.F.J.M., Oostveen, A.C., Lems, W.F., Dijkmans, B.A., Bruyn, G.A.W., Huisman, A.M., Jacobs, J.W., Hofbauer, L.C., Laet, C.E. de, Algra, A., Dijkmans, B.A.C., de Laet, C.E.D., Bruyn, G.A., Geusens, P.P., de Nijs, R.N., Buskens, E., Bijlsma, J.W., Bijlsma, J.W.J., Geusens, P.P.M.M., Laan, R.F.J., Huisman, A., Nijs, R.N. de, Oostveen, A.C.M., de Nijs, R.N.J.   +26 more
core   +1 more source

Clinical diagnosis and treatment recommendations for immune checkpoint inhibitor‐related adverse reactions in the nervous system

Thoracic Cancer, 2020
Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incidence rate is 0.1%–12% and 80% of nervous system adverse reactions occur within the first four months of application.
Jiayu Shi, Jingwen Niu, Dongchao Shen, Mingsheng Liu, Ying Tan, Yi Li, Yangyu huang, Liying Cui, Yuzhou Guan, Li Zhang   +9 more
doaj   +1 more source

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain [PDF]

, 2012
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin and
Linthorst, Astrid C E, Droste, Susanne K, Reul, Johannes M H M, Qian, Xiaoxiao, Lightman, Stafford L   +4 more
core   +1 more source

Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling

Frontiers in Endocrinology, 2023
As a treatment for various immune-mediated diseases, the use of glucocorticoids as anti-inflammatory and immunosuppressive agents is common practice.
Lisa Fleischhauer, Lisa Fleischhauer, Alejandra Cristina López-Delgado, Alejandra Cristina López-Delgado, Karina Geurtzen, Karina Geurtzen, Franziska Knopf, Franziska Knopf   +7 more
doaj   +1 more source

The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]

, 2007
Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C, Miner, JN, Farquharson, C; id_orcid, Owen, H C, Miner, J N, Ahmed, S F, Ahmed, SF, Owen, HC   +7 more
core   +1 more source

Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The contribution of glucocorticoids to sexual dimorphism in the heart is essentially unknown. Therefore, we sought to determine the sexually dimorphic actions of glucocorticoid signaling in cardiac function and gene expression.
Diana Cruz‐Topete, Robert H. Oakley, Natalie G. Carroll, Bo He, Page H. Myers, Xiaojiang Xu, Megan N. Watts, Krystle Trosclair, Edward Glasscock, Paari Dominic, John A. Cidlowski   +10 more
doaj   +1 more source

Case Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy

Frontiers in Immunology, 2023
Neuropsychiatric systemic lupus erythematosus (NPSLE) is the diagnosis that rheumatologists most often need to consider when a patient with lupus presents with neurologic symptoms.
Jialin Zhang, Jialin Zhang, Xiaodong Wu, Jing Xue, Lei Liu   +4 more
doaj   +1 more source

Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2 [PDF]

, 2010
Context: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder as a result of mutation in genes encoding either the ACTH receptor [melanocortin 2 receptor (MC2R)] or its accessory protein [melanocortin 2 receptor accessory ...
Metherell, LA, Chung, TTLL, Clark, AJ, Chung, TT, Chan, LF, Clark, AJL   +5 more
core   +1 more source