Results 11 to 20 of about 287,841 (259)

Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies

OncoImmunology, 2020
Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an ...
Yuting Ma, Heng Yang, Guido Kroemer
doaj   +1 more source

Hypoglycaemia in adrenal insufficiency

Frontiers in Endocrinology, 2023
Adrenal insufficiency encompasses a group of congenital and acquired disorders that lead to inadequate steroid production by the adrenal glands, mainly glucocorticoids, mineralocorticoids and androgens.
Shien Chen Lee, Elizabeth S. Baranowski, Rajesh Sakremath, Vrinda Saraff, Vrinda Saraff, Zainaba Mohamed, Zainaba Mohamed   +6 more
doaj   +1 more source

Abnormality of Aldosterone and Cortisol Late Pathways in Glucocorticoid-Remediable Aldosteronism. [PDF]

, 1994
Patients with glucocorticoid-remediable aldosteronism (GRA) possess a chimeric gene resulting from fusion of the genes encoding steroid aldosterone synthase and 11 beta-hydroxylase.
Boscaro, Marco, Kuhnle, Ursula, KUHNLE U, Fallo, Francesco, Sonino, Nicoletta   +4 more
core   +1 more source

Towards Non-Invasive Methods in Measuring Fish Welfare: The Measurement of Cortisol Concentrations in Fish Skin Mucus as a Biomarker of Habitat Quality

Animals, 2019
Cortisol levels in fish skin mucus have shown to be good stress indicators in farm fish exposed to different stressors. Its applicability in free-ranging animals subject to long-term environmental stressors though remains to be explored.
Annaïs Carbajal, Patricia Soler, Oriol Tallo-Parra, Marina Isasa, Carlos Echevarria, Manel Lopez-Bejar, Dolors Vinyoles   +6 more
doaj   +1 more source

The Negative Effect of Protein Phosphatase Z1 Deletion on the Oxidative Stress Tolerance of Candida albicans Is Synergistic with Betamethasone Exposure

Journal of Fungi, 2021
The glucocorticoid betamethasone (BM) has potent anti-inflammatory and immunosuppressive effects; however, it increases the susceptibility of patients to superficial Candida infections.
Ágnes Jakab, Tamás Emri, Kinga Csillag, Anita Szabó, Fruzsina Nagy, Edina Baranyai, Zsófi Sajtos, Dóra Géczi, Károly Antal, Renátó Kovács, Krisztina Szabó, Viktor Dombrádi, István Pócsi   +12 more
doaj   +1 more source

Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in αT3-1 and LβT2 Gonadotroph Cells

Biology, 2019
The regulation of reproductive function by glucocorticoids occurs at all levels of the hypothalamo-pituitary-gonadal axis. Within the pituitary, glucocorticoids have been shown to directly alter gene expression in gonadotrophs, indicating that these cell
Anthony E. Michael, Lisa M. Thurston, Robert C. Fowkes   +2 more
doaj   +1 more source

Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis

Biomolecules, 2021
Glucocorticoids (GCs), a class of corticosteroids produced by the adrenal cortex in response to stress, exert obesity-promoting effects. Although adaptive thermogenesis has been considered an effective approach to counteract obesity, whether GCs play a ...
Liping Luo, Lu Wang, Yan Luo, Estevan Romero, Xin Yang, Meilian Liu   +5 more
doaj   +1 more source

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain [PDF]

, 2012
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin and
Linthorst, Astrid C E, Droste, Susanne K, Reul, Johannes M H M, Qian, Xiaoxiao, Lightman, Stafford L   +4 more
core   +1 more source

Clinical diagnosis and treatment recommendations for immune checkpoint inhibitor‐related adverse reactions in the nervous system

Thoracic Cancer, 2020
Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incidence rate is 0.1%–12% and 80% of nervous system adverse reactions occur within the first four months of application.
Jiayu Shi, Jingwen Niu, Dongchao Shen, Mingsheng Liu, Ying Tan, Yi Li, Yangyu huang, Liying Cui, Yuzhou Guan, Li Zhang   +9 more
doaj   +1 more source

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring [PDF]

, 1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying this link are unknown but fetal exposure to excess glucocorticoids has been implicated, The fetus is normally protected from ...
Kenyon, C J, Seckl, J R, C J Kenyon, Burchell, A, R S Lindsay, A Burchell, J R Seckl, Lindsay, R S, M J Nyirenda, Nyirenda, M J   +9 more
core   +1 more source