Results 111 to 120 of about 228,409 (363)

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Is there a role for glucocorticoid receptor beta in asthma?

Respiratory Research, 2000
Glucocorticoids (GCs) are routinely used as anti-inflammatory drugs in the treatment of asthma. They act through binding to glucocorticoid receptor α (GRα), which represses numerous genes encoding pro-inflammatory mediators.
Gagliardo Rosalia, Vignola Antonio M, Mathieu Marc   +2 more
doaj   +1 more source

Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3 [PDF]

, 2016
The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking
A Amphoux, A Schmitt, Analisa Taylor, BA Nic Dhonnchadha, Beliz Kurtoglu, Brittany Nino, D Gründemann, D Gründemann, D Gründemann, DA Baker, David A Baker, DM Platt, E Schomig, EN Graf, F Martel, G Horvath, H Duan, HW Shen, Jayme R McReynolds, JJ Burmeister, JL Malisch, John R Mantsch, JR Mantsch, JR McReynolds, K Engel, LC Daws, LL Iversen, M Aliczki, M Cui, N Baganz, NL Baganz, O Vranjkovic, Oliver Vranjkovic, Olivia Derricks, Paul J Gasser, PJ Fletcher, PJ Gasser, PJ Gasser, R Sinha, R Sinha, R Zwart, Robert A Wheeler, S Erb, S Gong, SZ Langer, T Lenz, T Shang, Terra Ambrosius, V Gorboulev, V Vialou, V Vialou, XY Zhang   +51 more
core   +2 more sources

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.

Journal of Biological Chemistry, 1988
The effect of glucocorticoids on the regulation of glucocorticoid receptor mRNA was studied in two different cell lines, human IM-9 lymphocytes and rat pancreatic acinar AR42J cells. Using a glucocorticoid receptor cDNA probe, glucocorticoid receptor mRNA was examined by Northern blot hybridization and quantitated by slot-blot hybridization.
Ira D. Goldfine, S Rosewicz, Roger L. Miesfeld, Alexander R McDonald, Craig D. Logsdon, Betty A. Maddux   +5 more
openaire   +3 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer

Cell Reports, 2018
Summary: Steroid hormone receptors are simultaneously active in many tissues and are capable of altering each other’s function. Estrogen receptor α (ER) and glucocorticoid receptor (GR) are expressed in the uterus, and their ligands have opposing effects
Jeffery M. Vahrenkamp, Chieh-Hsiang Yang, Adriana C. Rodriguez, Aliyah Almomen, Kristofer C. Berrett, Alexis N. Trujillo, Katrin P. Guillen, Bryan E. Welm, Elke A. Jarboe, Margit M. Janat-Amsbury, Jason Gertz   +10 more
doaj   +1 more source

Critical roles of endogenous glucocorticoids for disease tolerance in malaria

, 2019
During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked.
De Bosscher, Karolien, Opdenakker, Ghislain, Van den Steen, Philippe E., Vandermosten, Leen, Vanhorebeek, Ilse   +4 more
core   +1 more source

Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland [PDF]

, 2011
The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid ...
Chan, LF, Clark, AJ, Gorrigan, RJ, Guasti, L, King, P   +4 more
core   +2 more sources