Results 131 to 140 of about 2,425,230 (388)

Interaction of Glucocorticoid Receptor (GR) with Estrogen Receptor (ER) α and Activator Protein 1 (AP1) in Dexamethasone-mediated Interference of ERα Activity*

Journal of Biological Chemistry, 2013
Background: How glucocorticoids affect ER-positive breast cancer cell proliferation is unclear. Results: GR occupies ERα-binding regions (EBRs) via tethering to AP1 and ERα. Conclusion: Interaction of GR with EBRs via ERα and AP1 inhibits E2-ERα activity.
S. Karmakar, Yetao Jin, A. K. Nagaich
semanticscholar   +1 more source

Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.

Journal of Biological Chemistry, 1988
The effect of glucocorticoids on the regulation of glucocorticoid receptor mRNA was studied in two different cell lines, human IM-9 lymphocytes and rat pancreatic acinar AR42J cells. Using a glucocorticoid receptor cDNA probe, glucocorticoid receptor mRNA was examined by Northern blot hybridization and quantitated by slot-blot hybridization.
Ira D. Goldfine, S Rosewicz, Roger L. Miesfeld, Alexander R McDonald, Craig D. Logsdon, Betty A. Maddux   +5 more
openaire   +3 more sources

Work Stressors and Asthma in Female and Male US Workers: Findings From the National Health Interview Survey

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Prior work has linked work stressors to asthma. However, research related to gender‐specific associations remains sparse and yielded mixed results. We aimed to address this gap. Methods We drew on cross‐sectional data from the 2015 National Health Interview Survey (individual‐level response rate = 79.7%).
Adrian Loerbroks, Haiou Yang, Jos A. Bosch, Julia Salandi, Stefanie Keymel, Jian Li   +5 more
wiley   +1 more source

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus

Cell Reports, 2019
Summary: Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid ...
Matthew D. Taves, Paul R. Mittelstadt, Diego M. Presman, Gordon L. Hager, Jonathan D. Ashwell   +4 more
doaj  

Partial purification of a glucocorticoid receptor. [PDF]

, 1975
Douglas Failla, Gordon M. Tomkins, Daniel V. Santi   +2 more
openalex   +1 more source

Ligand-Induced Repression of the Glucocorticoid Receptor Gene Is Mediated by an NCoR1 Repression Complex Formed by Long-Range Chromatin Interactions with Intragenic Glucocorticoid Response Elements

Molecular and Cellular Biology, 2013
Glucocorticoids are among the most potent and effective agents for treating inflammatory diseases and hematological cancers. However, subpopulations of patients are often resistant to steroid therapy, and determining the molecular mechanisms that ...
S. Ramamoorthy, J. Cidlowski
semanticscholar   +1 more source

Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance.

Endocrine Development, 2013
Glucocorticoids regulate a variety of physiological processes, and are commonly used to treat disorders of inflammation, autoimmune diseases, and cancer.
S. Ramamoorthy, J. Cidlowski
semanticscholar   +1 more source

GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers

Cell Reports, 2019
Summary: KDM1A-mediated H3K4 demethylation is a well-established mechanism underlying transcriptional gene repression, but its role in gene activation is less clear.
Erin A. Clark, Feizhen Wu, Yirui Chen, Paco Kang, Ursula B. Kaiser, Rui Fang, Yujiang G. Shi   +6 more
doaj  

Effects of pregnancy on neuron electrophysiology in prefrontal cortex, hippocampus, and basolateral amygdala of mouse brain

Animal Models and Experimental Medicine, EarlyView.
The electrophysiological change in neurons might contribute to the cognitive and emotional changes during pregnancy. Abstract Background Pregnancy affects learning and memory in women. Thus, to investigate the effects of pregnancy, the authors examined the brain electrophysiology of pregnant mice.
Xuefan Bin, Huijuan Luo
wiley   +1 more source

Myocarditis following COVID‐19 vaccine: incidence, presentation, diagnosis, pathophysiology, therapy, and outcomes put into perspective. A clinical consensus document supported by the Heart Failure Association of the European Society of Cardiology (ESC) and the ESC Working Group on Myocardial and Pericardial Diseases

European Journal of Heart Failure, Volume 24, Issue 11, Page 2000-2018, November 2022., 2022
Overview on incidence, diagnosis, and therapy in vaccine‐related myocarditis. CMR, cardiac magnetic resonance; EMB, endomyocardial biopsy; NSAIDS, non‐steroidal anti‐inflammatory drugs. Abstract Over 10 million doses of COVID‐19 vaccines based on RNA technology, viral vectors, recombinant protein, and inactivated virus have been administered worldwide.
Bettina Heidecker, Noa Dagan, Ran Balicer, Urs Eriksson, Giuseppe Rosano, Andrew Coats, Carsten Tschöpe, Sebastian Kelle, Gregory A. Poland, Andrea Frustaci, Karin Klingel, Pilar Martin, Joshua M. Hare, Leslie T. Cooper, Antonis Pantazis, Massimo Imazio, Sanjay Prasad, Thomas F. Lüscher   +17 more
wiley   +1 more source