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Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cells dysfunction in human cancer

Ward CJ, Chakraborty S, Shaji SK, Veiga-Villauriz C, Zhao Q, Chen X, Mahata B.   +6 more
europepmc   +1 more source

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The human glucocorticoid receptor

2023
Glucocorticoids are members of steroid hormones that are biosynthesized in the intermediate cellular zone of the adrenal cortex (zona fasciculata) and released into the peripheral blood as final products of the hypothalamic-pituitary-adrenal (HPA) axis, as well as under the control of the circadian biologic system.
Nicolas C, Nicolaides, George P, Chrousos   +1 more
openaire   +2 more sources

Glucocorticoid Receptors and Bone

Current Pharmaceutical Design, 2010
Glucocorticoid Receptors (GRs) have been identified in all bone cells. The molecular structure of human GR is organized into 3 major functional domains: the N-terminal immunogenic domain, the central DNA-binding domain and the C-terminal ligand-binding domain. Human GR is a product of a gene composed of 10 exons, located in the chromosome 5q31-32.
La Corte R, Trotta F, ADAMI, Silvano
openaire   +3 more sources

Regulation of glucocorticoid receptor gamma (GRγ) by glucocorticoid receptor haplotype and glucocorticoid

Clinical Endocrinology, 2004
Summaryobjective  To measure glucocorticoid receptor gamma (GRγ) expression in transformed lymphocytes from individuals of known GR gene haplotype. Recently, a glucocorticoid receptor haplotype (GAT) has been described that associates with increased sensitivity to dexamethasone.
Stevens, Adam, Donn, Rachelle, Ray, David   +2 more
openaire   +3 more sources

Glucocorticoid receptor blockers

Pituitary, 2022
Mifepristone is the only glucocorticoid receptor antagonist currently approved for the treatment of Cushing's syndrome. Although originally developed as an abortifacient due to its blockade of the progesterone receptor, a number of case reports documented its efficacy as a glucocorticoid receptor blocker going back to 1985. The SEISMIC trial, published
openaire   +2 more sources