Results 311 to 320 of about 199,077 (362)
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The glucocorticoid receptor and hypertension
Endocrine Research, 1994(1994). The glucocorticoid receptor and hypertension. Endocrine Research: Vol. 20, No. 2, pp. 101-116.
M. Panarelli, Robert Fraser
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The human glucocorticoid receptor
2023Glucocorticoids are members of steroid hormones that are biosynthesized in the intermediate cellular zone of the adrenal cortex (zona fasciculata) and released into the peripheral blood as final products of the hypothalamic-pituitary-adrenal (HPA) axis, as well as under the control of the circadian biologic system.
Nicolas C, Nicolaides +1 more
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Endocrine, 2007
We previously reported that glucocorticoid receptor (GR) blockade (injected with GR antagonist RU486) primed the host responses to lipopolysaccharide. Since decrease of GR and elevated glucocorticoids (GCs) have been always reported as parallel responses, we hypothesize that both GCs and GR play important roles in GR blockade induced priming.
Jie Fan +5 more
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We previously reported that glucocorticoid receptor (GR) blockade (injected with GR antagonist RU486) primed the host responses to lipopolysaccharide. Since decrease of GR and elevated glucocorticoids (GCs) have been always reported as parallel responses, we hypothesize that both GCs and GR play important roles in GR blockade induced priming.
Jie Fan +5 more
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2010
Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
John A. Cidlowski, Robert H. Oakley
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Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
John A. Cidlowski, Robert H. Oakley
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Glucocorticoid receptor blockers
Pituitary, 2022Mifepristone is the only glucocorticoid receptor antagonist currently approved for the treatment of Cushing's syndrome. Although originally developed as an abortifacient due to its blockade of the progesterone receptor, a number of case reports documented its efficacy as a glucocorticoid receptor blocker going back to 1985. The SEISMIC trial, published
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The structure of glucocorticoid receptors
The Journal of Steroid Biochemistry and Molecular Biology, 1993The glucocorticoid receptor of mouse thymic lymphoma cells was investigated. The receptor-hormone complex in cytosolic extracts has a Stokes' radius of 82 A and Mw approximately 330 kDa. In the presence of salt at high concentrations, however, the receptor-complex has a Stokes' radius of 60 A and Mw approximately 120 kDa.
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Localization of glucocorticoid receptors and glucocorticoid receptor mRNAs in the rat cochlea
The Laryngoscope, 1993AbstractThe distribution of glucocorticoid (GR) receptor messenger RNAs (mRNAs) and GR receptors was studied by in situ hybridization histochemistry and immunocytochemistry, respectively. In situ hybridization histochemistry was performed with a biotin‐labeled riboprobe complementary to rat GR receptor mRNA.
G. M. Small +4 more
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Glucocorticoid Receptor Antagonists
Current Topics in Medicinal Chemistry, 2008This review covers recent progress in the discovery of selective glucocorticoid receptor (GR) antagonists. Potential therapeutic applications of selective GR antagonists are described including the pharmacological rationale and, in some cases, clinical evidence that underlies these proposed uses. Disease areas that are discussed are Cushing's syndrome,
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Glucocorticoid Receptors In the Brain
Hospital Practice, 1988The ability to downregulate the stress response is essential to good health. We still have much to learn about the biochemical bases of glucocorticoid effects on brain function—but it is now clear that the interaction between hormones and neurons provides a pathway by which thoughts and emotions can influence hormone secretion and hormones can ...
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Genetics of glucocorticoid receptors
Molecular and Cellular Endocrinology, 1986The lymphocytolytic effect of glucocorticoids has been used for isolating receptor mutants. They fall into several groups with defects either in the hormone binding domain or the DNA binding domain or with part of the receptor polypeptide missing. These truncated receptors have increased binding affinity for general DNA and are synthesized from 5 ...
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