Results 251 to 260 of about 415,196 (303)
Some of the next articles are maybe not open access.
Glucocorticoids and the Osteoclast
Annals of the New York Academy of Sciences, 2007Abstract: Glucocorticoid (GC)‐induced bone loss is the most common cause of secondary osteoporosis but its pathogenesis is controversial. GCs clearly suppress bone formation in vivo but the means by which they impact osteoblasts is unclear. Because bone remodeling is characterized by tethering of the activities of the two cells, the osteoclast is a ...
Haibo Zhao +7 more
openaire +2 more sources
Glucocorticoids and Osteoporosis
Endocrinology and Metabolism Clinics of North America, 1994In summary, patients who will remain on glucocorticoids for more than a few weeks are clearly at risk for osteoporosis. A list of therapeutic strategies is provided in Table 2. While our therapy remains inadequate at this time, newer agents are on the horizon.
Clifford J. Rosen +3 more
openaire +3 more sources
Biochemistry (Moscow), 2006
Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoid resistance is a rare familial, or sporadic condition characterized by partial end-organ ...
openaire +4 more sources
Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoid resistance is a rare familial, or sporadic condition characterized by partial end-organ ...
openaire +4 more sources
Glucocorticoids in Pregnancy [PDF]
Current Pharmaceutical Biotechnology, 2011 The fetus may be exposed to increased endogenous or synthetic glucocorticoid (GS) exposure in late gestation. Approximately 7% of pregnant women in Europe and North America are treated with synthetic GSs to promote lung maturation in fetuses at risk of preterm delivery.
Beata Marciniak +5 more
openaire +2 more sources
2014
Glucocorticoids are the most effective anti-inflammatory treatment for allergic diseases, and inhaled glucocorticoids have now become the first-line treatment for asthma. Glucocorticoids were discovered in the 1940s as extracts of the adrenal cortex and this was followed by the isolation of adrenocorticotropic hormone (ACTH) from pituitary gland ...
openaire +2 more sources
Glucocorticoids are the most effective anti-inflammatory treatment for allergic diseases, and inhaled glucocorticoids have now become the first-line treatment for asthma. Glucocorticoids were discovered in the 1940s as extracts of the adrenal cortex and this was followed by the isolation of adrenocorticotropic hormone (ACTH) from pituitary gland ...
openaire +2 more sources
2002
Corticosteroids are highly effective anti-inflammatory therapy in asthma, and the molecular mechanisms involved in suppression of allergic inflammation are now better understood (Barnes 1998, 2001). Corticosteroids are effective clinically because they block many of the inflammatory pathways that are abnormally activated in asthma and they have a very ...
openaire +4 more sources
Corticosteroids are highly effective anti-inflammatory therapy in asthma, and the molecular mechanisms involved in suppression of allergic inflammation are now better understood (Barnes 1998, 2001). Corticosteroids are effective clinically because they block many of the inflammatory pathways that are abnormally activated in asthma and they have a very ...
openaire +4 more sources
Glucocorticoids and glucocorticoid receptors: mediators of fatigue?
Acta Neuropsychiatrica, 2003Fatigue is a common problem; when chronic and disabling, subjects can be categorized as having chronic fatigue syndrome (CFS). Whilst it is most likely a multifactorial condition of biopsychosocial origin, the nature of the pathophysiological component remains unclear.
openaire +3 more sources
Cochrane Database of Systematic Reviews, 2011
Since the initial publication of this systematic review in 1997, several randomized trials examining the benefit of glucocorticoids have been published. The objective of this review is to provide evidence to guide clinicians in their treatment of patients with croup by determining the effectiveness of glucocorticoids and to identify areas requiring ...
Kathleen O'Gorman +4 more
openaire +2 more sources
Since the initial publication of this systematic review in 1997, several randomized trials examining the benefit of glucocorticoids have been published. The objective of this review is to provide evidence to guide clinicians in their treatment of patients with croup by determining the effectiveness of glucocorticoids and to identify areas requiring ...
Kathleen O'Gorman +4 more
openaire +2 more sources
Defining the role of glucocorticoids in inflammation.
Clinical science, 2018An established body of knowledge and clinical practice has argued in favor of the use of glucocorticoids in various chronic inflammatory and autoimmune diseases.
S. Ronchetti +3 more
semanticscholar +1 more source
2019
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolas C, Nicolaides +1 more
openaire +2 more sources
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolas C, Nicolaides +1 more
openaire +2 more sources