Results 251 to 260 of about 173,033 (308)
Chronopharmacology of glucocorticoids
Advanced Drug Delivery Reviews, 2019 Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is the primary glucocorticoid in humans.
Naomi Schlesinger +1 more
exaly +4 more sources
New dimension of glucocorticoids in cancer treatment [PDF]
Steroids, 2016 [[abstract]]Glucocorticoids have been used in clinical oncology for over half of the century. The clinical applications of glucocorticoids in oncology are mainly dependent on their pro-apoptotic action to treat lymphoproliferative disorders, and also on ...
Kai-Ti Lin, Lu-Hai Wang
exaly +4 more sources
How Glucocorticoids Affect the Neutrophil Life [PDF]
International Journal of Molecular Sciences, 2018 Glucocorticoids are hormones that regulate several functions in living organisms and synthetic glucocorticoids are the most powerful anti-inflammatory pharmacological tool that is currently available.
Carlo Riccardi +2 more
exaly +3 more sources
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Best Practice & Research Clinical Rheumatology, 2011
Glucocorticoids remain part of the treatment strategy in many rheumatic diseases, because of their anti-inflammatory and immunosuppressive actions. Unfortunately, their clinically desired effects are linked to adverse effects, especially at higher dosages and longer duration of treatment.
Cornelia M, Spies +4 more
openaire +4 more sources
Glucocorticoids remain part of the treatment strategy in many rheumatic diseases, because of their anti-inflammatory and immunosuppressive actions. Unfortunately, their clinically desired effects are linked to adverse effects, especially at higher dosages and longer duration of treatment.
Cornelia M, Spies +4 more
openaire +4 more sources
Annals of the New York Academy of Sciences, 2004
Abstract: Epidemiological evidence suggests that an adverse fetal environment permanently programs physiology, leading to increased risks of cardiovascular, metabolic, and neuroendocrine disorders in adulthood. Prenatal glucocorticoid excess or stress might link fetal maturation and adult pathophysiology.
Jonathan R, Seckl, Michael J, Meaney
openaire +2 more sources
Abstract: Epidemiological evidence suggests that an adverse fetal environment permanently programs physiology, leading to increased risks of cardiovascular, metabolic, and neuroendocrine disorders in adulthood. Prenatal glucocorticoid excess or stress might link fetal maturation and adult pathophysiology.
Jonathan R, Seckl, Michael J, Meaney
openaire +2 more sources
Annals of the New York Academy of Sciences, 2006
Abstract: Disease modifying antirheumatic drugs (DMARDs) are drugs used in rheumatoid arthritis (RA) to control the disease and to limit joint damage and improve long‐term outcome. The last decade evidence has accumulated that suggests that low dosages of glucocorticoids are indeed able to control the disease and limit the destruction.
Bijlsma, Johannes W J +4 more
openaire +2 more sources
Abstract: Disease modifying antirheumatic drugs (DMARDs) are drugs used in rheumatoid arthritis (RA) to control the disease and to limit joint damage and improve long‐term outcome. The last decade evidence has accumulated that suggests that low dosages of glucocorticoids are indeed able to control the disease and limit the destruction.
Bijlsma, Johannes W J +4 more
openaire +2 more sources
2016
The most effective anti-inflammatory drugs used to treat patients with airways disease are topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to suppress airway inflammation or prevent the recruitment of inflammatory cells into the airway.
Adcock, IM, Mumby, S
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The most effective anti-inflammatory drugs used to treat patients with airways disease are topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to suppress airway inflammation or prevent the recruitment of inflammatory cells into the airway.
Adcock, IM, Mumby, S
openaire +3 more sources
Glucocorticoids and Osteoporosis
Endocrinology and Metabolism Clinics of North America, 1994In summary, patients who will remain on glucocorticoids for more than a few weeks are clearly at risk for osteoporosis. A list of therapeutic strategies is provided in Table 2. While our therapy remains inadequate at this time, newer agents are on the horizon.
R A, Adler, C J, Rosen
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Veterinary Dermatology, 2008
AbstractGlucocorticoids are one of the two main classes of hormones, along with mineralocorticoids, which are secreted from the adrenal cortex. Since the discovery of the anti‐inflammatory properties of the natural glucocorticoid hydrocortisone, a large number of artificial glucocorticoids have been synthesized to attempt to increase efficacy and ...
Andrew D, Lowe +2 more
openaire +2 more sources
AbstractGlucocorticoids are one of the two main classes of hormones, along with mineralocorticoids, which are secreted from the adrenal cortex. Since the discovery of the anti‐inflammatory properties of the natural glucocorticoid hydrocortisone, a large number of artificial glucocorticoids have been synthesized to attempt to increase efficacy and ...
Andrew D, Lowe +2 more
openaire +2 more sources
Current Opinion in Rheumatology, 1989
Despite the continuing debate about the risks and benefits of glucocorticoid, their central role in the therapeutic armamentarium remains undisputed. Studies continue to unravel the complexity of their biologic effects on gene transcription, and careful clinical observation refines their therapeutic use.
openaire +3 more sources
Despite the continuing debate about the risks and benefits of glucocorticoid, their central role in the therapeutic armamentarium remains undisputed. Studies continue to unravel the complexity of their biologic effects on gene transcription, and careful clinical observation refines their therapeutic use.
openaire +3 more sources