Results 301 to 310 of about 393,042 (353)

Glucocorticoid-remediable Aldosteronism

Endocrinology and Metabolism Clinics of North America, 2011
Glucocorticoid-remediable aldosteronism (GRA) is a hereditary form of primary hyperaldosteronism and the most common monogenic cause of hypertension. A chimeric gene duplication leads to ectopic aldosterone synthase activity in the cortisol-producing zona fasciculata of the adrenal cortex, under the regulation of adrenocorticotropin (ACTH ...
Florencia, Halperin, Robert G, Dluhy
openaire   +2 more sources

Glucocorticoid Feedback Resistance

Trends in Endocrinology & Metabolism, 1997
Glucocorticoid feedback resistance can be inherited or locally acquired. The implications of these two forms of resistance for disease are strikingly different. The inherited form is characterized by enhanced adrenocortical function and hypercorticism to compensate for a generalized deficit in the glucocorticoid receptor gene, but these individuals ...
de Kloet, E.R., Vreugdenhil, M., Oitzl, M.S., Joëls, M.   +3 more
openaire   +4 more sources

Defining the role of glucocorticoids in inflammation.

Clinical science, 2018
An established body of knowledge and clinical practice has argued in favor of the use of glucocorticoids in various chronic inflammatory and autoimmune diseases.
S. Ronchetti, G. Migliorati, S. Bruscoli, C. Riccardi   +3 more
semanticscholar   +1 more source

Glucocorticoid resistance

Biochemistry (Moscow), 2006
Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoid resistance is a rare familial, or sporadic condition characterized by partial end-organ ...
openaire   +3 more sources

Glucocorticoid-Induced Osteoporosis

Hormone Research in Paediatrics, 2003
Osteoporosis is a common and serious complication of glucocorticoid therapy, resulting in increased risk of fragility fractures. Recent studies indicate that fracture risk is increased even at low doses of glucocorticoids and that this increased risk is seen soon after the commencement of glucocorticoid therapy.
openaire   +2 more sources

Glucocorticoid-induced osteoporosis

Best Practice & Research Clinical Endocrinology & Metabolism, 1998
Glucocorticoid drugs interact with bone metabolism at many levels, but their principal action is to reduce osteoblast number and bone matrix synthesis. Virtually all patients receiving glucocorticoids in doses above 5 mg per day lose bone, the amount lost being dependent on the cumulative steroid dose.
openaire   +2 more sources

Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases

Nature Reviews Rheumatology, 2020
R. Hardy, K. Raza, M. Cooper
semanticscholar   +1 more source

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.

Endocrine reviews, 2000
R. Sapolsky, L. Romero, A. Munck
semanticscholar   +1 more source

Glucocorticoids

Acta Paediatrica, 1994
A, Greenough, B, Yüksel
openaire   +2 more sources

Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.

Endocrine reviews, 1984
A. Munck, P. Guyre, N. Holbrook
semanticscholar   +1 more source