Results 181 to 190 of about 31,450 (226)
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Biochimica et Biophysica Acta (BBA) - Enzymology, 1977
1. Glucokinase (ATP : D-glucose 6-phosphotransferase, EC 2.7.1.2) was extracted from pea seeds and purified by fractionation with (NH4)2SO4 and chromatography on DEAE-cellulose and Sephadex. 2. The relative rates of phosphorylation of glucose, mannose and fructose (final concentration 5 mM) were 100, 64 and 11. 3.
J F, Turner, Q J, Chensee, D D, Harrison
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1. Glucokinase (ATP : D-glucose 6-phosphotransferase, EC 2.7.1.2) was extracted from pea seeds and purified by fractionation with (NH4)2SO4 and chromatography on DEAE-cellulose and Sephadex. 2. The relative rates of phosphorylation of glucose, mannose and fructose (final concentration 5 mM) were 100, 64 and 11. 3.
J F, Turner, Q J, Chensee, D D, Harrison
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Sigmoidal Kinetics of Glucokinase
Enzyme, 1975Glucokinases obtained from the liver of several species of mammals and amphibians exhibit sigmoidal saturation functions for glucose. Hill coefficients (nH) are about 1.5, and half-saturation values (K0.5) lie between 1.5 and 8.5 mmol/l. The nH and K0.5 values are constant throughout the purification steps of rat glucokinase.
H, Niemeyer +5 more
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Mechanism of liver glucokinase
Molecular and Cellular Biochemistry, 1982Glucokinase is the enzyme primarily responsible for the phosphorylation of glucose in the livers of mammals and other vertebrates. It differs from the other hexokinases in being insensitive to inhibition by glucose 6-phosphate and in responding co-operatively to changes in the glucose concentration in the physiological range.
D, Pollard-Knight, A, Cornish-Bowden
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Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus
Diabetes, 1997Glucokinase (GK) plays a central role in the sensing of glucose in pancreatic β-cells and parenchymal cells of the liver. Glucokinase regulatory protein is a physiological inhibitor of GK in the liver. To understand the role of the interaction of these two proteins in glucose sensing, we carried out a series of experiments to localize the protein in ...
K S, Brown +4 more
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Expert Opinion on Therapeutic Patents, 2014
Glucokinase (GK) is a key regulator of glucose homeostasis, and development of small molecule activators of this enzyme represents a promising new approach for the treatment of type 2 diabetes mellitus.This manuscript reviews small molecule patent disclosures between late 2011 and February 2014 for both GK activators (GKAs) and GK-glucokinase ...
Kevin J, Filipski +1 more
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Glucokinase (GK) is a key regulator of glucose homeostasis, and development of small molecule activators of this enzyme represents a promising new approach for the treatment of type 2 diabetes mellitus.This manuscript reviews small molecule patent disclosures between late 2011 and February 2014 for both GK activators (GKAs) and GK-glucokinase ...
Kevin J, Filipski +1 more
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Multiple Forms of Hepatic Glucokinase
Biochemical Society Transactions, 1976Reports of two bands having glucokinase (EC 2.7.1.2) activity on starch-gel electrophoretograms (Pilkis HHansen etal., 1970; Shattonetal., 1969) havebeen difficult to interpret because of technical problems of reproducibility, perhaps owing to the instability of the enzyme during the 16h separation period.
M B, Allen, D G, Walker
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