Results 171 to 180 of about 31,450 (226)
Circadian nutrition meets intermittent hypoxia: a timely fix for dysglycemia? [PDF]
Masury H, Fradkov S, Gileles-Hillel A.
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Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets. [PDF]
Kyohara M +13 more
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Randomized Double-blind Placebo-controlled study to evaluate the efficacy of fermented deglycyrrhizinated licorice for treatment of diabetic polyneuropathy. [PDF]
Massoud AMA +3 more
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Network Pharmacology-Based Elucidation of the Hypoglycemic Mechanism of <i>Grifola frondosa</i> GF5000 Polysaccharides via GCK modulation in Diabetic Rats. [PDF]
Xiao C +5 more
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Editorial: NAFLD treatment in diabetes: from current dietary interventions to novel treatment. [PDF]
Nevola R, Costabile G, Della Pepa G.
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Pharmaceutical Patent Analyst, 2012
In this review we highlight recently disclosed progress in the field of small-molecule activators of the human glucokinase enzyme. Several of the reported chemotypes possess structural features that diverge from known leads; some of these modifications appear to be specifically designed to modulate tissue selectivity or discrete parameters of enzyme ...
Kevin J, Filipski +3 more
openaire +4 more sources
In this review we highlight recently disclosed progress in the field of small-molecule activators of the human glucokinase enzyme. Several of the reported chemotypes possess structural features that diverge from known leads; some of these modifications appear to be specifically designed to modulate tissue selectivity or discrete parameters of enzyme ...
Kevin J, Filipski +3 more
openaire +4 more sources
Bioorganic & Medicinal Chemistry Letters, 2005
The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.
Arlindo L, Castelhano +16 more
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The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.
Arlindo L, Castelhano +16 more
openaire +2 more sources
Role of ATP-glucokinase and polyphosphate glucokinase inStreptomyces aureofaciens
Folia Microbiologica, 1976The activity of ATP-glucokinase and of polyphosphate glucokinase was examined during growth of the actinomycete Streptomyces aureofaciens 8425 under conditions of intense chlortetracycline (CTC) synthesis. ATP-glucokinase was active in the strain only during the logarithmic phase of culture growth; the activity of polyphosphate glucokinase appears only
Z, Hostálek +3 more
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