Results 171 to 180 of about 21,204 (221)

Co-localization of glucokinase with actin filaments [PDF]

FEBS Letters, 1997
A portion of glucokinase appeared to be co-localized with actin filaments in the cytoplasm of cultured rat hepatocytes incubated with 25 mM glucose. When liver- or islet-type glucokinase was transiently expressed in COS-7 cells, the expressed glucokinase
Hisamitsu Ishihara, Y Shibasaki, I Miwa   +2 more
exaly   +2 more sources

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A patent review of glucokinase activators and disruptors of the glucokinase – glucokinase regulatory protein interaction: 2011 – 2014

Expert Opinion on Therapeutic Patents, 2014
Glucokinase (GK) is a key regulator of glucose homeostasis, and development of small molecule activators of this enzyme represents a promising new approach for the treatment of type 2 diabetes mellitus.This manuscript reviews small molecule patent disclosures between late 2011 and February 2014 for both GK activators (GKAs) and GK-glucokinase ...
Jeffrey A Pfefferkorn
exaly   +3 more sources

Glucokinase Activators

Pharmaceutical Patent Analyst, 2012
In this review we highlight recently disclosed progress in the field of small-molecule activators of the human glucokinase enzyme. Several of the reported chemotypes possess structural features that diverge from known leads; some of these modifications appear to be specifically designed to modulate tissue selectivity or discrete parameters of enzyme ...
Kevin J, Filipski, Kentaro, Futatsugi, Jeffrey A, Pfefferkorn, Benjamin D, Stevens   +3 more
openaire   +2 more sources

Role of ATP-glucokinase and polyphosphate glucokinase inStreptomyces aureofaciens

Folia Microbiologica, 1976
The activity of ATP-glucokinase and of polyphosphate glucokinase was examined during growth of the actinomycete Streptomyces aureofaciens 8425 under conditions of intense chlortetracycline (CTC) synthesis. ATP-glucokinase was active in the strain only during the logarithmic phase of culture growth; the activity of polyphosphate glucokinase appears only
Z, Hostálek, I, Tobek, M A, Bobyk, I S, Kulayev   +3 more
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Glucokinase of pea seeds

Biochimica et Biophysica Acta (BBA) - Enzymology, 1977
1. Glucokinase (ATP : D-glucose 6-phosphotransferase, EC 2.7.1.2) was extracted from pea seeds and purified by fractionation with (NH4)2SO4 and chromatography on DEAE-cellulose and Sephadex. 2. The relative rates of phosphorylation of glucose, mannose and fructose (final concentration 5 mM) were 100, 64 and 11. 3.
J F, Turner, Q J, Chensee, D D, Harrison
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Sigmoidal Kinetics of Glucokinase

Enzyme, 2017
Glucokinases obtained from the liver of several species of mammals and amphibians exhibit sigmoidal saturation functions for glucose. Hill coefficients (n(H)) are about 1.5, and half-saturation values (K(0.5)) lie between 1.5 and 8.5 mmol/1. The nn and K(0.5) values are constant throughout the purification steps of rat glucokinase.
H, Niemeyer, M, de la Luz Cárdenas, E, Rabajille, T, Ureta, L, Clark-Turri, J, Peñaranda   +5 more
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Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes

Mini-Reviews in Medicinal Chemistry
Abstract: The glucokinase regulator (GCKR) gene encodes an inhibitor of the glucokinase enzyme (GCK), found only in hepatocytes and responsible for glucose metabolism. A common GCKR coding variation has been linked to various metabolic traits in genome-wide association studies.
Smita Jain, Sarvesh Paliwal, Swapnil Sharma   +2 more
exaly   +3 more sources

Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus

Diabetes, 1997
Glucokinase (GK) plays a central role in the sensing of glucose in pancreatic β-cells and parenchymal cells of the liver. Glucokinase regulatory protein is a physiological inhibitor of GK in the liver. To understand the role of the interaction of these two proteins in glucose sensing, we carried out a series of experiments to localize the protein in ...
K S, Brown, S S, Kalinowski, J R, Megill, S K, Durham, K A, Mookhtiar   +4 more
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Mechanism of liver glucokinase

Molecular and Cellular Biochemistry, 1982
Glucokinase is the enzyme primarily responsible for the phosphorylation of glucose in the livers of mammals and other vertebrates. It differs from the other hexokinases in being insensitive to inhibition by glucose 6-phosphate and in responding co-operatively to changes in the glucose concentration in the physiological range.
D, Pollard-Knight, A, Cornish-Bowden
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Glucokinase-activating ureas

Bioorganic & Medicinal Chemistry Letters, 2005
The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.
Arlindo L, Castelhano, Hanqing, Dong, Matthew C T, Fyfe, Lisa S, Gardner, Yukari, Kamikozawa, Satomi, Kurabayashi, Masao, Nawano, Rikiya, Ohashi, Martin J, Procter, Li, Qiu, Chrystelle M, Rasamison, Karen L, Schofield, Vilas K, Shah, Kiichiro, Ueta, Geoffrey M, Williams, David, Witter, Kosuke, Yasuda   +16 more
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