Results 171 to 180 of about 31,450 (226)

Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets. [PDF]

open access: yesSci Rep
Kyohara M   +13 more
europepmc   +1 more source
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Glucokinase Activators

Pharmaceutical Patent Analyst, 2012
In this review we highlight recently disclosed progress in the field of small-molecule activators of the human glucokinase enzyme. Several of the reported chemotypes possess structural features that diverge from known leads; some of these modifications appear to be specifically designed to modulate tissue selectivity or discrete parameters of enzyme ...
Kevin J, Filipski   +3 more
openaire   +4 more sources

Glucokinase-defective NIDDM

Lancet, The, 1993
Hideki Katagiri   +4 more
exaly   +2 more sources

Glucokinase-activating ureas

Bioorganic & Medicinal Chemistry Letters, 2005
The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.
Arlindo L, Castelhano   +16 more
openaire   +2 more sources

Role of ATP-glucokinase and polyphosphate glucokinase inStreptomyces aureofaciens

Folia Microbiologica, 1976
The activity of ATP-glucokinase and of polyphosphate glucokinase was examined during growth of the actinomycete Streptomyces aureofaciens 8425 under conditions of intense chlortetracycline (CTC) synthesis. ATP-glucokinase was active in the strain only during the logarithmic phase of culture growth; the activity of polyphosphate glucokinase appears only
Z, Hostálek   +3 more
openaire   +2 more sources

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