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Molecules, 2021 Gluconeogenesis is a key interface between organic acid/amino acid/lipid and sugar metabolism. The aims of this article are four-fold. First, to provide a concise overview of plant gluconeogenesis.
Robert P. Walker +2 more
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Unraveling the Regulation of Hepatic Gluconeogenesis
Frontiers in Endocrinology, 2019 Hepatic gluconeogenesis, de novo glucose synthesis from available precursors, plays a crucial role in maintaining glucose homeostasis to meet energy demands during prolonged starvation in animals.
Xueping Zhang +3 more
doaj +2 more sources
Insulin regulation of gluconeogenesis [PDF]
Annals of the New York Academy of Sciences, 2018 AbstractThe coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of hepatic glucose release, through controlling the processes of de novo glucose production ...
M. Hatting +4 more
semanticscholar +4 more sources
Cerebral Gluconeogenesis and Diseases [PDF]
Frontiers in Pharmacology, 2017 The gluconeogenesis pathway, which has been known to normally present in the liver, kidney, intestine, or muscle, has four irreversible steps catalyzed by the enzymes: pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-bisphosphatase ...
James Yip +3 more
semanticscholar +4 more sources
Doxycycline alters metabolism and proliferation of human cell lines. [PDF]
, 2013 The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells-including inhibition of the mitochondrial ribosome-there have been few ...
Ahler, Ethan +7 more
core +13 more sources
Frontiers in Cell and Developmental Biology, 2022 Reprogramming of glucose metabolism occurs in many human tumor types, and one of these, gluconeogenesis, is known to exhibit anti-tumor effects in hepatocellular carcinoma (HCC). The transcription factor NFYA regulates gluconeogenesis in the normal liver
Goki Tsujimoto +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus, yet the mechanism by which it lowers plasma glucose concentrations has remained elusive.
Traci E LaMoia +13 more
semanticscholar +1 more source
Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease
Journal of the American Society of Nephrology, 2022 Significance Statement The ability to produce glucose from nonhexose precursors is a main metabolic function of renal proximal tubule (PT) cells. PT cells adapt metabolically during CKD, but little is known about gluconeogenesis in chronically injured PT
Thomas Verissimo +21 more
semanticscholar +1 more source
Science Advances, 2022 Previously, we found that α-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1). Here, we demonstrated the beneficial effects of AKG on glucose homeostasis in a diet-induced obesity (DIO) mouse ...
Yexian Yuan +13 more
semanticscholar +1 more source
A reduction in age-enhanced gluconeogenesis extends lifespan. [PDF]
PLoS ONE, 2013 The regulation of energy metabolism, such as calorie restriction (CR), is a major determinant of cellular longevity. Although augmented gluconeogenesis is known to occur in aged yeast cells, the role of enhanced gluconeogenesis in aged cells remains ...
Mayumi Hachinohe +6 more
doaj +1 more source