Results 1 to 10 of about 171,466 (287)

Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows [PDF]

Journal of Animal Science and Biotechnology
Background Ruminants and monogastric animals exhibit significant differences in gluconeogenic efficiency. In dairy cows, hepatic gluconeogenesis serves as the primary source of glucose.
Miaomiao Zhu, Yining Zheng, Shiyang Lou, Ruixu Zhang, Dingping Feng, Xinjian Lei, Lei Chen, Jianguo Wang, Junhu Yao, Lu Deng   +9 more
doaj   +2 more sources

NFYA promotes the anti-tumor effects of gluconeogenesis in hepatocellular carcinoma through the regulation of PCK1 expression

Frontiers in Cell and Developmental Biology, 2022
Reprogramming of glucose metabolism occurs in many human tumor types, and one of these, gluconeogenesis, is known to exhibit anti-tumor effects in hepatocellular carcinoma (HCC). The transcription factor NFYA regulates gluconeogenesis in the normal liver
Goki Tsujimoto, Rin Ito, Kei Yoshikawa, Chihiro Ueki, Nobuhiro Okada   +4 more
doaj   +1 more source

Gluconeogenesis in Plants: A Key Interface between Organic Acid/Amino Acid/Lipid and Sugar Metabolism

Molecules, 2021
Gluconeogenesis is a key interface between organic acid/amino acid/lipid and sugar metabolism. The aims of this article are four-fold. First, to provide a concise overview of plant gluconeogenesis.
Robert P. Walker, Zhi-Hui Chen, Franco Famiani   +2 more
doaj   +1 more source

Transcriptomic Analysis Reveals Glycolysis and Gluconeogenesis Pathway Activation Underlying Growth Enhancement by Duck-Blood Protein Hydrolysate in Flowerhorn Cichlid Fish. [PDF]

Int J Mol Sci
Manassila P, Sangsawad P, Boonanuntanasarn S, Kaewda J, Boonchuen P, Limkul S, Nakharuthai C.   +6 more
europepmc   +3 more sources

A reduction in age-enhanced gluconeogenesis extends lifespan. [PDF]

PLoS ONE, 2013
The regulation of energy metabolism, such as calorie restriction (CR), is a major determinant of cellular longevity. Although augmented gluconeogenesis is known to occur in aged yeast cells, the role of enhanced gluconeogenesis in aged cells remains ...
Mayumi Hachinohe, Midori Yamane, Daiki Akazawa, Kazuhiro Ohsawa, Mayumi Ohno, Yuzu Terashita, Hiroshi Masumoto   +6 more
doaj   +1 more source

Glucagon Promotes Gluconeogenesis through the GCGR/PKA/CREB/PGC-1α Pathway in Hepatocytes of the Japanese Flounder Paralichthys olivaceus

Cells, 2023
In order to investigate the mechanism of glucagon regulation of gluconeogenesis, primary hepatocytes of the Japanese flounder (Paralichthys olivaceus) were incubated with synthesized glucagon, and methods based on inhibitors and gene overexpression were ...
Mengxi Yang, Mingzhu Pan, Dong Huang, Jiahuan Liu, Yanlin Guo, Yue Liu, Wenbing Zhang   +6 more
doaj   +1 more source

The effect of aerobic exercise on the function of the local renin-angiotensin system and gluconeogenesis pathway in the liver tissue of type 2 diabetic rats [PDF]

مجله علوم پزشکی فیض (پیوسته), 2023
Background and Aim: One of the important and effective physiological systems in the pathogenesis of type 2 diabetes is the local renin-angiotensin system. The aim of the current study was to determine the effect of aerobic exercise on the function of the
Mohadeseh Shojaei, Fatemeh Kazeminasab, Mohammadjavad Pourvaghar   +2 more
doaj   +2 more sources

Olfr78, a novel short‐chain fatty acid receptor, regulates glucose homeostasis and gut GLP‐1 secretion in mice

Food Frontiers, 2023
Olfr78, which is a novel receptor for short‐chain fatty acid (SCFA) acetate and propionate, plays essential roles in some cellular processes. The present study aimed to investigate the role of olfr78 in regulating energy metabolism and delineate the ...
Yanan Wang, Mengjie Li, Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +5 more
doaj   +1 more source

Analogous Metabolic Decoupling in Pseudomonas putida and Comamonas testosteroni Implies Energetic Bypass to Facilitate Gluconeogenic Growth

mBio, 2021
Gluconeogenic carbon metabolism is not well understood, especially within the context of flux partitioning between energy generation and biomass production, despite the importance of gluconeogenic carbon substrates in natural and engineered carbon ...
Rebecca A. Wilkes, Jacob Waldbauer, Ludmilla Aristilde   +2 more
doaj   +1 more source

Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway

Molecular Metabolism, 2020
Objective: Salt-induced kinase 1 (SIK1) acts as a key modulator in many physiological processes. However, the effects of SIK1 on gluconeogenesis and the underlying mechanisms have not been fully elucidated. In this study, we found that a natural compound
Siwen Liu, Suling Huang, Xingde Wu, Ying Feng, Yu Shen, Qin-shi Zhao, Ying Leng   +6 more
doaj   +1 more source