Results 1 to 10 of about 74,459 (251)

Enhanced glucose production in norepinephrine and palmitate stimulated hepatocytes following endurance training [PDF]

open access: yesFrontiers in Physiology
Enhanced hepatic gluconeogenesis plays an important role in exercise glucose homeostasis when hepatic glycogen stores are depleted. Livers from trained animals demonstrate greater rates of gluconeogenesis in the presence of elevated substrate with and ...
Ken D. Sumida   +2 more
doaj   +2 more sources

Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α [PDF]

open access: yesMolecular Metabolism
Background: As the primary source of glucose during fasting, hepatic gluconeogenesis is rigorously regulated to maintain euglycemia. Abnormal gluconeogenesis in the liver can lead to hyperglycemia, a key diagnostic marker and the primary pathological ...
Xiaomin Luo   +9 more
doaj   +2 more sources

NFYA promotes the anti-tumor effects of gluconeogenesis in hepatocellular carcinoma through the regulation of PCK1 expression

open access: yesFrontiers in Cell and Developmental Biology, 2022
Reprogramming of glucose metabolism occurs in many human tumor types, and one of these, gluconeogenesis, is known to exhibit anti-tumor effects in hepatocellular carcinoma (HCC). The transcription factor NFYA regulates gluconeogenesis in the normal liver
Goki Tsujimoto   +4 more
doaj   +1 more source

Gluconeogenesis in Plants: A Key Interface between Organic Acid/Amino Acid/Lipid and Sugar Metabolism

open access: yesMolecules, 2021
Gluconeogenesis is a key interface between organic acid/amino acid/lipid and sugar metabolism. The aims of this article are four-fold. First, to provide a concise overview of plant gluconeogenesis.
Robert P. Walker   +2 more
doaj   +1 more source

A reduction in age-enhanced gluconeogenesis extends lifespan. [PDF]

open access: yesPLoS ONE, 2013
The regulation of energy metabolism, such as calorie restriction (CR), is a major determinant of cellular longevity. Although augmented gluconeogenesis is known to occur in aged yeast cells, the role of enhanced gluconeogenesis in aged cells remains ...
Mayumi Hachinohe   +6 more
doaj   +1 more source

Recent advances of long non-coding RNAs in control of hepatic gluconeogenesis

open access: yesFrontiers in Endocrinology, 2023
Gluconeogenesis is the main process for endogenous glucose production during prolonged fasting, or certain pathological conditions, which occurs primarily in the liver.
Zhe Wang   +4 more
doaj   +1 more source

Analogous Metabolic Decoupling in Pseudomonas putida and Comamonas testosteroni Implies Energetic Bypass to Facilitate Gluconeogenic Growth

open access: yesmBio, 2021
Gluconeogenic carbon metabolism is not well understood, especially within the context of flux partitioning between energy generation and biomass production, despite the importance of gluconeogenic carbon substrates in natural and engineered carbon ...
Rebecca A. Wilkes   +2 more
doaj   +1 more source

Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway

open access: yesFrontiers in Pharmacology, 2021
Hengshun aromatic vinegar (HSAV), produced by typical solid-state or liquid-state fermentation techniques, is consumed worldwide as a food condiment.
Guoquan Li   +9 more
doaj   +1 more source

The molecular mechanism of propionate-regulating gluconeogenesis in bovine hepatocytes [PDF]

open access: yesAnimal Bioscience, 2023
Objective Cows that are nursing get around 80% of their glucose from liver gluconeogenesis. Propionate, a significant precursor of liver gluconeogenesis, can regulate the key genes involved in hepatic gluconeogenesis expression, but its precise effects ...
Rui Pang   +7 more
doaj   +1 more source

Identification and Functional Characterization of Arabidopsis icl Mutant Under Trehalose Feeding in Light and Dark Conditions [PDF]

open access: yesJournal of Genetic Resources, 2019
Trehalose is a non-reducing sugar that plays an important role in plant growth and development. To study the role of trehalose on lipid metabolism and gluconeogenesis, Arabidopsis thaliana wild type (WT) and TreF (a line expressing trehalase) were grown ...
Aniseh Noroozipoor   +2 more
doaj   +1 more source

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