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Studies on gluconeogenesis

Advances in Enzyme Regulation, 1964
Summary Following stimulation with adrenal steroids a series of metabolic changes occur leading to increased protein catabolism and increased glucose production. Specific hepatic enzymes whose activities are known to increase under these conditions are: glucose-6-phosphatase, phosphohexose isomerase, fructose diphosphatase, phosphoenolpyruvate ...
James Ashmore, T. Uete, S.R. Wagle
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Glucagon and Gluconeogenesis [PDF]

open access: possible, 1983
Gluconeogenesis is the process whereby lactate, pyruvate, glycerol, and certain amino acids are converted to glucose and glycogen. The liver is the major site of gluconeogenesis, although the kidney becomes important during prolonged starvation. The most important function of gluconeogenesis is the maintenance of blood glucose levels during times when ...
Charles R. Park   +2 more
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Glycolysis and Gluconeogenesis

2021
Carbon metabolic pathways are called central metabolic pathways as these are the key pathways to generate energy and intermediates for the synthesis of biomolecules. The major carbon metabolic pathways are glycolysis/glycolytic pathway/Embden–Meyerhoff–Parnas pathway (EMP), pentose phosphate pathway (PPP) and Entner–Doudoroff (ED) pathway.
Rani Gupta, Namita Gupta
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Disorders of gluconeogenesis

Journal of Inherited Metabolic Disease, 1996
SummaryGluconeogenesis, or the formation of glucose from mainly lactate/pyruvate, glycerol and alanine, plays an essential role in the maintenance of normoglycaemia during fasting. Inborn deficiencies are known of each of the four enzymes of the glycolytic — gluconeogenic pathway that ensure a unidirectional flux from pyruvate to glucose: pyruvate ...
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Gluconeogenesis in the fetus and neonate

Seminars in Perinatology, 2000
Gluconeogenesis (GNG), a key metabolic process, involves the formation of glucose and glycogen from non-glucose precursors via pyruvate. In the strict sense, it also includes the contribution of glycerol as well as recycled glucose carbon (Cori's cycle).
Prabhu S. Parimi, Satish C. Kalhan
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Gluconeogenesis in Birds

Biochemical Society Transactions, 1978
It is a characteristic of all avian species that they maintain a plasma glucose concentration between 9 and 15 mM under all physiological circumstances. Even starvation for up to 9 days failed to lower the blood sugar concentration of chickens (Hazelwood & Lorenz, 1959).
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Hepatic gluconeogenesis in chickens

Molecular and Cellular Biochemistry, 1978
Gluconeogenesis by isolated hepatocytes resulted in glucose release but insignificant rates of glycogen synthesis. The effectiveness of precursors was similar for hepatocytes from fed and starved chickens except for impaired gluconeogenesis from pyruvate when compared to lactate in lactate starved chicken hepatocytes.
Derek R. Langslow, A. J. Dickson
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Gluconeogenesis and the peroxisome.

Molecular and cellular biochemistry, 1997
In this article, the capabilities of peroxisomal involvement in the gluconeogenetic processes of vertebrate animals are reviewed in the light of recent findings on peroxisomal metabolism and proliferation. It is demonstrated that the participation of this organelle affords the potential of alternative pathways for the conversion of triacylglycerols to ...
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Regulation of gluconeogenesis by alanine

Biochimica et Biophysica Acta (BBA) - General Subjects, 1974
Abstract 1. 1. L -alanine and α-amino-isobutyric acid (0.5–10 mM) have been shown to stimulate glucose formation by isolated kidney tubules from fed and starved rats, with the substrates pyruvate, lactate, fructose, malate, fumarate, α-oxoglutarate and glycerol.
Wilhelm Schoner, Dagmar Friedrichs
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Gluconeogenesis in vertebrate livers

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1977
1. The hypothesis is advanced that it would be logical for a tissue (liver) to evolve as a gluconeogenic organ in order to recover the lactate produced as a result of rapid and sustained contraction of skeletal muscle. 2. Lactate was present in skeletal muscle of all animals examined and increased following electrical stimulation.
J.W. Phillips, F.J.R. Hird
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