Results 31 to 40 of about 134,956 (333)

Glucagon Promotes Gluconeogenesis through the GCGR/PKA/CREB/PGC-1α Pathway in Hepatocytes of the Japanese Flounder Paralichthys olivaceus

Cells, 2023
In order to investigate the mechanism of glucagon regulation of gluconeogenesis, primary hepatocytes of the Japanese flounder (Paralichthys olivaceus) were incubated with synthesized glucagon, and methods based on inhibitors and gene overexpression were ...
Mengxi Yang, Mingzhu Pan, Dong Huang, Jiahuan Liu, Yanlin Guo, Yue Liu, Wenbing Zhang   +6 more
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Disruption of pyruvate phosphate dikinase in Brucella ovis PA CO2-dependent and independent strains generates attenuation in the mouse model

Veterinary Research, 2020
Brucella ovis is a non-zoonotic rough Brucella that causes genital lesions, abortions and increased perinatal mortality in sheep and is responsible for important economic losses worldwide. Research on virulence factors of B.
Nieves Vizcaíno, Lara Pérez-Etayo, Raquel Conde-Álvarez, Maite Iriarte, Ignacio Moriyón, Amaia Zúñiga-Ripa   +5 more
doaj   +1 more source

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]

, 2019
TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn, Kang, Hyun Je, Kwon, Hyug Moo, Kwon, Mi Jin, Lee-Kwon, Whaseon, Lim, Sun Woo, Nam, Dougu, Park, Hyun, Sanada, Satoru, Yoo, Eun Jin, Yoon, Sora   +10 more
core   +1 more source

The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α

Animal Nutrition, 2022
Cattle can efficiently perform de novo generation of glucose through hepatic gluconeogenesis to meet post-weaning glucose demand. Substantial evidence points to cattle and non-ruminant animals being characterized by phylogenetic features in terms of ...
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng   +8 more
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FAM3D inhibits gluconeogenesis in high glucose environment via DUSP1/ZFP36/SIK1 axis

Kaohsiung Journal of Medical Sciences, 2023
Hyperglycemia is the most important factor leading to the complications of type 2 diabetes mellitus (T2DM). The primary condition for the treatment of T2DM is to change the glucose and lipid metabolism disorders in the liver and other insulin‐sensitive ...
Bin Huang, Yue‐Ling Luo, Jun‐Ling Huang, Guang‐Zhi Li, Shi‐Yuan Qiu, Chun‐Chun Huang   +5 more
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Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway

Molecular Metabolism, 2020
Objective: Salt-induced kinase 1 (SIK1) acts as a key modulator in many physiological processes. However, the effects of SIK1 on gluconeogenesis and the underlying mechanisms have not been fully elucidated. In this study, we found that a natural compound
Siwen Liu, Suling Huang, Xingde Wu, Ying Feng, Yu Shen, Qin-shi Zhao, Ying Leng   +6 more
doaj  

Possible evidence of gluconeogenesis in Plasmodium- Infected children in relationship with the parasite density

Biomedical and Biotechnology Research Journal, 2020
Background: Gluconeogenesis is stimulated by low blood glucose to maintain the glucose level; it involves lipolysis (breaking down of triglycerides), release of cortisol, and production of glycerol which can be converted into glucose.
Mathew Folaranmi Olaniyan, Tolulope Busayo Ojediran, Shedarck Gbenga Olayinka   +2 more
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Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis

IUCrJ, 2023
Enolase, a ubiquitous enzyme, catalyzes the reversible conversion of 2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP) in the glycolytic pathway of organisms of all three domains of life. The underlying mechanism of the 2PG to PEP conversion has been
Mohammed Ahmad, Bhavya Jha, Sucharita Bose, Satish Tiwari, Abhisek Dwivedy, Deepshikha Kar, Ravikant Pal, Richard Mariadasse, Tanya Parish, Jeyaraman Jeyakanthan, Kutti R. Vinothkumar, Bichitra Kumar Biswal   +11 more
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SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose Stimulation and Downregulates Hsp60 among Other Proteins in HepG2 Liver Cell Lines

Molecules, 2018
SLC35B4, solute receptor for UDP-N-acetylglucosamine and UDP-xylose, is associated with diabetes and predisposing conditions. This study investigated the localization of SLC35B4 and compared the differential expression between a knockdown of SLC35B4 and ...
Brigitte Wex, Rémi M. Safi, Gregory Antonios, Perla Z. Zgheib, Dania B. Awad, Firas H. Kobeissy, Rami A. Mahfouz, Marwan M. El-Sabban, Soha N. Yazbek   +8 more
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Vitamin B2 enables regulation of fasting glucose availability

eLife, 2023
Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of metabolism (IEMs)
Peter M Masschelin, Pradip Saha, Scott A Ochsner, Aaron R Cox, Kang Ho Kim, Jessica B Felix, Robert Sharp, Xin Li, Lin Tan, Jun Hyoung Park, Liping Wang, Vasanta Putluri, Philip L Lorenzi, Alli M Nuotio-Antar, Zheng Sun, Benny Abraham Kaipparettu, Nagireddy Putluri, David D Moore, Scott A Summers, Neil J McKenna, Sean M Hartig   +20 more
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