Results 31 to 40 of about 162,740 (383)
American Journal of Clinical Nutrition, 2020 BACKGROUND Glycolysis/gluconeogenesis and tricarboxylic acid (TCA) cycle metabolites have been associated with type 2 diabetes (T2D). However, the associations of these metabolites with T2D incidence and the potential effect of dietary interventions ...
M. Guasch-Ferré +26 more
semanticscholar +1 more source
Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]
, 2019 TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn +10 more
core +1 more source
Biomedical and Biotechnology Research Journal, 2020 Background: Gluconeogenesis is stimulated by low blood glucose to maintain the glucose level; it involves lipolysis (breaking down of triglycerides), release of cortisol, and production of glycerol which can be converted into glucose.
Mathew Folaranmi Olaniyan +2 more
doaj +1 more source
Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice
Journal of Lipid Research, 2023 Neonates strive to acquire energy when the continuous transplacental nutrient supply ceases at birth, whereas milk consumption takes hours to start.
Liangkui Li +11 more
doaj +1 more source
IUCrJ, 2023 Enolase, a ubiquitous enzyme, catalyzes the reversible conversion of 2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP) in the glycolytic pathway of organisms of all three domains of life. The underlying mechanism of the 2PG to PEP conversion has been
Mohammed Ahmad +11 more
doaj +1 more source
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]
, 2015 Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise +7 more
core +1 more source
Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo
Nature Network Boston, 2018 Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-lowering effects by inhibiting hepatic gluconeogenesis.
A. Madiraju +14 more
semanticscholar +1 more source
Ontogenic Profile of Gluconeogenic Key Enzyme Gene Expressions in Embryonic Chicken Liver and Muscle
The Journal of Poultry Science, 2013 To elucidate biochemical mechanisms underlining high plasma glucose in chicken embryo, gene expression profile of gluconeogenic key enzymes were characterized.
Tushar K. Roy +4 more
doaj +1 more source
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]
, 2015 The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam +16 more
core +2 more sources
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer
Molecular Oncology, 2020 Inhibition of glycolysis has been considered as a therapeutic approach in aggressive cancers including lung cancer. Abbreviated gluconeogenesis, mediated by phosphoenolpyruvate carboxykinase (PEPCK), was recently discovered to partially circumvent the ...
E. Smolle +10 more
semanticscholar +1 more source