Results 61 to 70 of about 74,459 (251)
Cell Reports, 2017 The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for systemic metabolic adaptations such as gluconeogenesis and ketogenesis.
Jieun Lee +7 more
doaj +1 more source
Advanced Science, EarlyView.Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi +13 more
wiley +1 more source
Animal, 2020 Since nutritional requirements are increased at the end of gestation to meet the demands of the pregnant uterus, pregnant beef cows are susceptible to mobilization of body reserves (mainly fat and amino acids (AAs)) and to alter the metabolism of ...
R.C. Lopes +8 more
doaj
Advanced Science, EarlyView.Network‐based risk stratification of people living with HIV (PWH) on prolonged therapy using multi‐omics data identifies 44% of the patients are at risk of immunometabolic complications. A senescence‐associated myeloid cell‐driven plasma microenvironment drives immunometabolic dysregulation in at‐risk PWH.
Flora Mikaeloff +32 more
wiley +1 more source
The Plant Genome, Volume 15, Issue 4, December 2022., 2022 Abstract As an important family of pathogenesis‐related (PR) proteins, the functional diversification and roles of PR10s in biotic stress have been well documented. However, the molecular basis of PR10s in plant defense responses against pathogens remains to be further understood.
Jin Guo +6 more
wiley +1 more source
Food Frontiers, 2023 Olfr78, which is a novel receptor for short‐chain fatty acid (SCFA) acetate and propionate, plays essential roles in some cellular processes. The present study aimed to investigate the role of olfr78 in regulating energy metabolism and delineate the ...
Yanan Wang +5 more
doaj +1 more source
Self-organization and fractality created by gluconeogenesis in the metabolic process [PDF]
Chaotic Modeling and Simulation, 2, pp.113-127 (2016), 2017 Within a mathematical model, the process of interaction of the metabolic processes such as glycolysis and gluconeogenesis is studied. As a result of the running of two opposite processes in a cell, the conditions for their interaction and the self-organization in a single dissipative system are created.
arxiv
Advanced Science, EarlyView.LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao +7 more
wiley +1 more source
Veterinary Medicine and Science, Volume 9, Issue 1, Page 336-344, January 2023., 2023 The high‐yielding dairy cows suffer from insulin resistance during the periparturient period. Dietary supplementation of pioglitazone hydrochloride, an insulin‐resistance drug and synthetic agonist for PPRAγ, improved the insulin sensitivity index (RQICKI‐BHBA) in Holstein dairy cows during the transition period. Abstract Background High‐yielding dairy
Saeed Mirzaie +4 more
wiley +1 more source
Advanced Science, EarlyView.Macrophage phenotypes are influenced by the microenvironment. Matrix stiffness, a key ECM factor, polarizes macrophage toward a pro‐regenerative phenotype in a 3D physiological environment. CaMKK2 selectively regulates stiffness‐induced macrophage polarization, impacting tumor growth and wound healing.
Ya Guan +7 more
wiley +1 more source