Results 71 to 80 of about 88,788 (276)

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

Retrospective Study of Reported Adverse Events Due to Complementary Health Products in Singapore From 2010 to 2016

Frontiers in Medicine, 2018
The objective of this study is to collate and analyse adverse event reports associated with the use of complementary health products (CHP) submitted to the Health Sciences Authority (HSA) of Singapore for the period 2010–2016 to identify various trends ...
Yimin Xu, Yimin Xu, Dhavalkumar N. Patel, Suet-Leng P. Ng, Siew-Har Tan, Dorothy Toh, Jalene Poh, Adena Theen Lim, Cheng-Leng Chan, Cheng-Leng Chan, Min-Yong Low, Hwee-Ling Koh   +11 more
doaj   +1 more source

Assessment of In Vitro Nano‐Cytotoxicity Through Fluorescence Microscopy via Neural Network‐Based Live/Dead Cell Classification

Advanced Intelligent Systems, EarlyView.
FluoAI is a two‐stage, label‐free method for quantifying nanomaterial‐induced cytotoxicity from conventional fluorescence microscopy images. Mask R‐CNN segmentation and DenseNet‐121 classification provide rapid live/dead classification matching human accuracy.
Ugur C. Topkiran, Ali Gasimli, Lal Durmaz, Diya Vashani, Himish Paul, Giridhar R. Akkaraju, Anton V. Naumov   +6 more
wiley   +1 more source

Glucosamine-Sulfate On Fracture Healing [PDF]

, 2013
BACKGROUND The aim of this study is to determine whether glucosamine-sulfate has any effects on bone-healing. METHODS A unilateral fracture was created in the tibia of sixty-one female rats. Rats were given no drug or 230 mg/kg glucosamine- sulfate daily.
Akin Ugras, Guzel, Elif, Fatih Dikici, Elif Guzel, Cetinus, Ercan, Kaya, Ibrahim, Petek Korkusuz, Uğraş, Akın, Dikici, Fatih, Emrah Demirbas, Ercan Cetinus, Korkusuz, Petek, Demirbas, Emrah, Ibrahim Kaya, Ugras, Akin   +14 more
core   +1 more source

Integrating Cartilage Explant Culture with Simulated Digestion and Hepatic Biotransformation Refines In Vitro Screening of Joint Care Nutraceuticals

Methods and Protocols
In vitro cartilage explant culture has been used to assess nutraceuticals on cartilage responses to inflammatory stimuli. However, applying extracts of nutraceuticals directly to cartilage explants does not account for effects of digestion and hepatic ...
Michelina Crosbie, Kailey Vanderboom, Jamie Souccar-Young, Wendy Pearson   +3 more
doaj   +1 more source

The efficacy of two-drug regimen of glucosamine and chloroquine compared to one-drug regimen of glucosamine in treatment of knee osteoarthritis [PDF]

Objective: This study aimed to compare the clinical efficacy of two-drug regimen of glucosamine and chloroquine with one-drug regimen of glucosamine in treatment of knee osteoarthritis.
محرم زاد, یاشار, پورفرضی, فرهاد, جستان, مارینا   +2 more
core  

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Glucosamine-mediated immunomodulation after stroke is sexually dimorphic

Brain, Behavior, & Immunity - Health, 2020
Growing evidence suggests that galectin-3 (Gal-3) is instrumental in orchestrating innate immune response and microglia activation following different brain pathologies. However, its role remains controversial. We recently showed that a readily available
Reza Rahimian, Melanie Lalancette-Hébert, Yuan Cheng Weng, Sachiko Sato, Jasna Kriz   +4 more
doaj   +1 more source

Mean inter- and intra-day accuracy, precision, reproducibility and linearity for glucosamine hydrochloride and glucosamine sulphate.

, 2019
Mean inter- and intra-day accuracy, precision, reproducibility and linearity for glucosamine hydrochloride and glucosamine sulphate.
Chhavi Asthana (6667769), Rahul P. Patel (698431), Madhur Shastri (6667772), Gregory M. Peterson (564167)   +3 more
core   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source