Results 11 to 20 of about 15,165 (218)

Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice [PDF]

Journal of Diabetes Investigation, 2019
Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent ...
Satoko Shimazu‐Kuwahara, Yoshinori Kanemaru, Norio Harada, Eri Ikeguchi, Yohei Ueda, Shunsuke Yamane, Yuki Murata, Akihiro Yasoda, Timothy J Kieffer, Nobuya Inagaki   +9 more
doaj   +2 more sources

The Effect of Porcine Orexin a on Glucose-Dependent Insulinotropic Polypeptide Plasma Concentrations in Pigs

European Journal of Inflammation, 2010
The orexigenic system was discovered in 1998. It consists of two neuropeptides, Orexin A and Orexin B. Researchers have focused more on Orexin A, since its intracerebroventricular injection into the lateral ventricle of the rat's brain causes an increase
P. Papakonstantinou, N. Tziris, D. Kapoukranidou, A. Gotzamani-Psarrakou, C.H.R. Tsonidis, M.N. Patsikas, G. Papazoglou   +6 more
doaj   +2 more sources

Glucose-dependent insulinotropic polypeptide and tissue inflammation: Implications for atherogenic cardiovascular disease

European Journal of Inflammation, 2022
Glucose-dependent insulinotropic polypeptide (GIP) has pleiotropic actions on pancreatic endocrine function, adipose tissue lipid metabolism, and skeletal calcium metabolism.
Xiaoming He
doaj   +1 more source

Regulation of glucose and energy metabolism through actions of glucagon‐like peptide‐1 and glucose‐dependent insulinotropic polypeptide [PDF]

Journal of Diabetes Investigation
Yasuo Zenimaru, Norio Harada
doaj   +2 more sources

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Beat Müller, Tanja Radimerski, Ralph Peterli, Ulrich Keller, Christ-Crain, Mirjam, Daniel M. Frey, Timper, Katharina, Frey, Daniel M., Mirjam Christ-Crain, Jean Grisouard, Häring, Andreas, Zulewski, Henryk, Keller, Ulrich, Grisouard, Jean, Katharina Timper, Henryk Zulewski, Radimerski, Tanja, Müller, Beat, Kaethi Dembinski, Dembinski, Kaethi, Andreas Häring, Peterli, Ralph   +21 more
core   +1 more source

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Nature Communications, 2020
Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models.
Elizabeth A. Killion, Michelle Chen, James R. Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M. Véniant, David J. Lloyd   +12 more
doaj   +1 more source

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

mAbs, 2020
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases.
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant, Zhulun Wang   +17 more
doaj   +1 more source

Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists

Endocrinology Research and Practice, 2022
Glucagon-like peptide-1 is the most potent incretin secreted from the intestinal tract. It is synthesized by L-cells in the jejunum and distal ileum of the gastrointestinal system.
Dilek Tüzün
doaj  

Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion. [PDF]

, 2019
Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted from the upper small intestine, which plays an important physiological role in the control of glucose metabolism through its incretin action to enhance glucose-dependent insulin
Moss, Catherine E., Diakogiannaki, Eleftheria, Gribble, Fiona M., Reimann, Frank   +3 more
core   +1 more source

Effects of passage through the digestive tract on incretin secretion: Before and after birth

Journal of Diabetes Investigation, 2021
Aims/Introduction It was reported that fetuses secrete endogenous incretin; however, the stimulants of fetal incretin secretion are not fully understood.
Seiichi Tomotaki, Ryosuke Araki, Kouji Motokura, Yutaro Tomobe, Takeru Yamauchi, Shintaro Hanaoka, Hiroko Tomotaki, Kougoro Iwanaga, Fusako Niwa, Junko Takita, Masahiko Kawai   +10 more
doaj   +1 more source