Results 11 to 20 of about 3,377,134 (229)

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J., Ong, Wee Kiat, Furman, Brian   +2 more
core   +4 more sources

Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease

Endocrine Reviews
M Michael Wolfe, William W Chin
exaly   +2 more sources

Regulation of glucose and energy metabolism through actions of glucagon‐like peptide‐1 and glucose‐dependent insulinotropic polypeptide [PDF]

Journal of Diabetes Investigation
Yasuo Zenimaru, Norio Harada
doaj   +2 more sources

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Beat Müller, Tanja Radimerski, Ralph Peterli, Ulrich Keller, Christ-Crain, Mirjam, Daniel M. Frey, Timper, Katharina, Frey, Daniel M., Mirjam Christ-Crain, Jean Grisouard, Häring, Andreas, Zulewski, Henryk, Keller, Ulrich, Grisouard, Jean, Katharina Timper, Henryk Zulewski, Radimerski, Tanja, Müller, Beat, Kaethi Dembinski, Dembinski, Kaethi, Andreas Häring, Peterli, Ralph   +21 more
core   +1 more source

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
Isken, Frank, Weickert, Martin O., Pfeiffer, Andreas F. H., Möhlig, Matthias, Abdelrahman, A., Thorens, B., Klaus, Susanne, Nogueiras, R., Tschöp, M. H.   +8 more
core   +1 more source

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Nature Communications, 2020
Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models.
Elizabeth A. Killion, Michelle Chen, James R. Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M. Véniant, David J. Lloyd   +12 more
doaj   +1 more source

Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists

Endocrinology Research and Practice, 2022
Glucagon-like peptide-1 is the most potent incretin secreted from the intestinal tract. It is synthesized by L-cells in the jejunum and distal ileum of the gastrointestinal system.
Dilek Tüzün
doaj  

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

mAbs, 2020
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases.
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant, Zhulun Wang   +17 more
doaj   +1 more source

Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice

Journal of Diabetes Investigation, 2019
Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent ...
Satoko Shimazu‐Kuwahara, Yoshinori Kanemaru, Norio Harada, Eri Ikeguchi, Yohei Ueda, Shunsuke Yamane, Yuki Murata, Akihiro Yasoda, Timothy J Kieffer, Nobuya Inagaki   +9 more
doaj   +1 more source

The equine glucose-dependent insulinotropic polypeptide receptor: A potential therapeutic target for insulin dysregulation [PDF]

, 2017
Metabolic disease is a significant problem that causes a range of species-specific comorbidities. Recently, a better understanding of glucose-dependent insulinotropic polypeptide (GIP) biology has led to the suggestion that inhibiting its action may ...
M. H. Kheder, M. N. Sillence, M. A. de Laat, Bryant, Litticia M., Kheder, M.H., L. M. Bryant, Sillence, M.N., de Laat, M.A.   +7 more
core   +1 more source