Results 91 to 100 of about 67,753 (222)

Genetic variability in Oligosarcus paranensis (Teleostei: Characiformes) from the São Francisco river, Ivaí river basin – Paraná State, Brazil - doi: 10.4025/actascibiolsci.v35i3.14179

Acta Scientiarum: Biological Sciences, 2013
The genetic variability of Oligosarcus paranensis was estimated from a population collected in São Francisco river, Prudentópolis county in Paraná State (Brazil) using the electrophoresis in starch gel technique.
Michele Rocha dos Santos, Erasmo Renesto
doaj   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Autoantibodies against glucose-6-phosphate isomerase are not a diagnostic marker for juvenile idiopathic arthritis [PDF]

Annals of the Rheumatic Diseases, 2004
Rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) are chronic inflammatory diseases that primarily affect the joints. The triggers that activate autoreactive T and B lymphocytes in arthritic patients are still unknown.1 It has been widely assumed, however, that the autoantigens recognised by arthritogenic lymphocytes are joint-specific.
C Sengler, A Schmitt, T Kamradt, D Schubert   +3 more
openaire   +3 more sources

A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells

Immunology &Cell Biology, EarlyView.
In this article, we adapted the SCENITH assay to measure the metabolism of rare cells in vivo. We observed that, under steady‐state conditions, lung T cells were highly dependent on oxidative phosphorylation for energy production. Further, metabolic inhibitors that interfere with protein translation and energy availability downregulated Foxp3 ...
Aristeidis Roubanis, Morgane Hilaire, Morgane Le Teuff, Odile Devergne, Tim Sparwasser, Luciana Berod, Benoît L Salomon   +6 more
wiley   +1 more source

Genetic variability in Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae) from the Upper Paraná River basin, Brazil

Genetics and Molecular Biology, 2005
Allozyme data was used to assess the genetic diversity Astyanax altiparanae populations from the floodplain of the Upper Paraná River (PR). Specimens were collected in the southern Brazilian state of Paraná from PR in Porto Rico municipality and Ribeirão
Maria Dolores Peres, Marcio dos Santos Vasconcelos, Erasmo Renesto   +2 more
doaj   +1 more source

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, EarlyView.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source

Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review

Journal of Periodontal Research, EarlyView.
Untargeted salivary proteomics identified promising biological molecules consistently over‐ or under‐expressed in periodontitis patients compared to periodontally healthy subjects, but further targeted approaches are required for their validation. ABSTRACT Aim Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases ...
Matteo Corana, Giacomo Baima, Giovanni Iaderosa, Francesco Franco, Jianjian Zhang, Giovanni Nicolao Berta, Federica Romano, Mario Aimetti   +7 more
wiley   +1 more source

Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase

Biomolecules, 2019
The cupin-type phosphoglucose isomerase (PfPGI) from the hyperthermophilic archaeon Pyrococcus furiosus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Kalyanasundaram Subramanian, Karolina Mitusińska, John Raedts, Feras Almourfi, Henk-Jan Joosten, Sjon Hendriks, Svetlana E. Sedelnikova, Servé W. M. Kengen, Wilfred R. Hagen, Artur Góra, Vitor A. P. Martins dos Santos, Patrick J. Baker, John van der Oost, Peter J. Schaap   +13 more
doaj   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

An HWE‐Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response

Molecular Microbiology, EarlyView.
The HWE‐family histidine kinase PhyK regulates the cell envelope structure of the intracellular pathogen Brucella ovis and affects how the host immune system responds to this bacterium. Deletion of phyK alters bacterial survival in the face of detergent stress and reduces immune activation in infected macrophages.
Xingru Chen, Emily Perez, Eleanor C. Scheeres, Rosemary Northcote, Aretha Fiebig, Andrew J. Olive, Sean Crosson   +6 more
wiley   +1 more source