Results 91 to 100 of about 98,446 (260)

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
wiley   +1 more source

Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI

Frontiers in Pharmacology, 2020
Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells.
Song-Tao Wu, Bo Liu, Bo Liu, Bo Liu, Zhong-Zhu Ai, Zhong-Zhu Ai, Zhong-Zhu Ai, Zong-Chao Hong, Peng-Tao You, Peng-Tao You, Peng-Tao You, He-Zhen Wu, He-Zhen Wu, He-Zhen Wu, Yan-Fang Yang, Yan-Fang Yang, Yan-Fang Yang   +16 more
doaj   +1 more source

On the distribution and characteristics of isozyme expression in Mycoplasma, Acholeplasma, and Ureaplasma species. [PDF]

, 1983
A summary of a survey of three genera of mycoplasmatales (Mycoplasma, Acholeplasma, and Ureaplasma) for isozyme expression is presented. Isozyme analysis of mycoplasmas has been employed in at least three distinct areas: (1) as genetic markers for ...
Barile, M. F., O'Brien, S. J., Razin, S., Simonson, J. M.   +3 more
core   +2 more sources

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism

Microbial Cell Factories, 2022
Background The methylotrophic budding yeast Pichia pastoris GS115 is a powerful expression system and hundreds of heterologous proteins have been successfully expressed in this strain. Recently, P.
Qiquan Zhang, Xiaolu Wang, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huoqing Huang, Bin Yao, Yingguo Bai, Jie Zhang   +11 more
doaj   +1 more source

The silicon trypanosome [PDF]

, 2010
African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
BARBARA M. BAKKER, CHRISTINE CLAYTON, Duffieux, HANS V. WESTERHOFF, Hornberg, KEITH MATTHEWS, MARK GIROLAMI, MICHAEL P. BARRETT, PAUL A. M. MICHELS, R. LUISE KRAUTH-SIEGEL, RAINER BREITLING   +10 more
core   +4 more sources

A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations

ChemBioChem, EarlyView.
Site‐specifically phosphorylated isoforms of the tumor suppressor p53 – encompassing all seven known phosphorylation sites within the TAD1 domain –are created upon optimization of semisynthesis protocols. This “designer" p53 library enabled validation of phosphorylation‐specific p53 antibodies and revealed epitope masking by phosphorylation in commonly
Mateusz Hess, Jonathan H. Davies, Sofia Margiola, Sonja Schneider, Thomas Hicks, Nishant Rai, Manuel M. Müller   +6 more
wiley   +1 more source

Using phosphoglucose isomerase-deficient (pgi1Δ) Saccharomyces cerevisiae to map the impact of sugar phosphate levels on d-glucose and d-xylose sensing

Microbial Cell Factories, 2022
Background Despite decades of engineering efforts, recombinant Saccharomyces cerevisiae are still less efficient at converting d-xylose sugar to ethanol compared to the preferred sugar d-glucose.
Celina Borgström, Viktor C. Persson, Oksana Rogova, Karen O. Osiro, Ester Lundberg, Peter Spégel, Marie Gorwa-Grauslund   +6 more
doaj   +1 more source

Evaluating the typing power of six isoenzymatic systems for differentiation of clinical and standard isolates of Candida species

Advanced Biomedical Research, 2023
Background: Due to the increasing prevalence of candidiasis, early detection of the causative agents may pave the way for the management of this infection.
Gholamreza Hatam, Hamid Morovati, Marzieh Alikhani, Amir Rahimi, Keyvan Pakshir, Sara Amini, Kamiar Zomorodian   +6 more
doaj   +1 more source

Valorization of Apple Pomace: Production of Phloretin Using a Bacterial Cellulose‐Immobilized β‐Glycosidase

ChemSusChem, EarlyView.
This study presents a whole valorization of apple processing waste: phloretin is efficiently produced from phloridzin (abundantly found in apple residues), using a β‐glycosidase immobilized on bacterial cellulose in a biphasic system. Notably, bacterial cellulose is derived from fermentation of apple pomace sugars, making both the enzyme carrier and ...
Agostina Colacicco, Luca Nespoli, Emma Ribul Moro, Stefano Farris, Francesco Molinari, Diego Romano, Martina Letizia Contente   +6 more
wiley   +1 more source