Glucose-6-phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis. [PDF]
Arthritis Res Ther, 2015 IntroductionFibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of glucose 6-phosphate isomerase (GPI) in the proliferation of RA-FLS.MethodsThe distribution
Zong M +7 more
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Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model. [PDF]
Sci Rep, 2015 Peptidyl arginine deiminase 4 (PAD4) is an enzyme that is involved in protein citrullination and is a target for anti-citrullinated peptide antibodies (ACPAs) in rheumatoid arthritis (RA).
Seri Y +6 more
europepmc +2 more sources
Combination treatment with fingolimod and a pathogenic antigen prevents relapse of glucose-6-phosphate isomerase peptide-induced arthritis. [PDF]
Immun Inflamm Dis, 2016 Combination treatment with fingolimod (FTY720) plus pathogenic antigen is thought to prevent glucose‐6‐phosphate isomerase (GPI)325‐339‐induced arthritis progression by effective induction of immune tolerance.
Yoshida Y +8 more
europepmc +2 more sources
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells. [PDF]
BMC Cancer, 2016 BackgroundFor a long time cancer cells are known for increased uptake of glucose and its metabolization through glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key regulatory enzyme of this pathway and can produce ATP through oxidative ...
Das MR +10 more
europepmc +2 more sources
High-resolution melting (HRM)-based detection of polymorphisms in the malic enzyme and glucose-6-phosphate isomerase genes for Leishmania infantum genotyping. [PDF]
Parasit Vectors, 2023 Buffi G +10 more
europepmc +3 more sources
Allozymes of glucose-6-phosphate isomerase differentially modulate pentose-shunt metabolism in the sea anemone Metridium senile. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1989 We tested the hypothesis that kinetic differences among allelic variants of glucose-6-phosphate isomerase (GPI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) from the sea anemone Metridium senile differentially modulate glucose metabolism at the ...
William E. Zamer, Ruth Hoffmann
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Pharmacological Research, 2023 Melanoma is a dangerous form of skin cancer, making it important to investigate new mechanisms and approaches to enhance the effectiveness of treatment.
Lei Wang +8 more
doaj +2 more sources
Glucose-6-phosphate isomerase is not a specific autoantigen in rheumatoid arthritis. [PDF]
Rheumatology, 2003 OBJECTIVE To test the hypothesis that glucose-6-phosphate isomerase (GPI) is a novel autoantigen in RA. METHODS Eighty-eight serum samples from 23 patients with rheumatoid arthritis (RA), 25 with Sjögren's syndrome, 20 with systemic lupus erythematosus
C. Hervé, R. Wait, P. J. Venables
semanticscholar +3 more sources
Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase [PDF]
Arthritis Research & Therapy, 2005 Antibodies specific for glucose-6-phosphate isomerase (G6PI) from T-cell receptor transgenic K/BxN mice are known to induce arthritis in mice, and immunization of DBA/1 mice with G6PI led to acute arthritis without permanent deformation of their joints ...
R. Bockermann +3 more
semanticscholar +6 more sources
Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis [PDF]
Arthritis Research & Therapy, 2008 IntroductionImmunization with glucose-6-phosphate isomerase (GPI) induces severe arthritis in DBA/1 mice. The present study was designed to identify the cytokines and co-stimulatory molecules involved in the development of GPI-induced arthritis ...
Isao Matsumoto +9 more
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